Article
Licensed
Unlicensed
Requires Authentication
Benefits of the iQ200 automated urine microscopy analyser in routine urinalysis
-
Daan van den Broek
Published/Copyright:
November 1, 2008
Abstract
Background: Urine microscopic analysis is hampered by its lack in standardisation and semi-quantitative reports, resulting in limited reliability. Automation of urinalysis could overcome these problems.
Methods: We compared the performance of the iQ200 with traditional microscopy and strip analysis in routine urinalysis. A total of 1482 routine samples, positive in dipstick testing, were evaluated for erythrocytes, leukocytes, casts, dysmorphic erythrocytes and bacteria using the iQ200 and traditional microscopy. The results of 320 of these samples were linked to underlying urological pathology as well as results from bacterial culturing.
Results: Analytically, the iQ200 surpasses traditional microscopy. The identification of casts and dysmorphic erythrocytes in routine samples improves when using the iQ200, although the sub-classification of casts required well-trained technicians. The auto-classification of particles was least reliable for yeast and bacterial cocci. The quantitative reports, and therefore the use of precise cut-off points allowed earlier and improved detection of urinary tract pathology.
Conclusions: The performance of the iQ200 is equal to traditional microscopy, but it strongly improves the reliability of urinalysis by standardisation, quantitative reports and improved workflow. From a clinical point of view, renewed attention and improvement of routine urinalysis aids in the efficient detection of renal and urinary tract pathology.
Clin Chem Lab Med 2008;46:1635–40.
Received: 2008-5-19
Accepted: 2008-7-21
Published Online: 2008-11-01
Published in Print: 2008-11-01
©2008 by Walter de Gruyter Berlin New York
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Editorial
- Biochemical markers in clinical cardiology: perspectives from present to future. 1st IFCC-Ortho Clinical Diagnostics Conference on Clinical Diagnosis and the Clinical Laboratory
- Highlight: Cardiovascular Biomarkers
- Reviews
- The clinical impact of the universal diagnosis of myocardial infarction
- Troponin revisited 2008: assay performance
- Standardization of troponin I measurements: an update
- Biochemistry of B-type natriuretic peptide – where are we now?
- Clinical relevance of non-cardiac determinants of natriuretic peptide levels
- What is the value of B-type natriuretic peptide testing for diagnosis, prognosis or monitoring of critically ill adult patients in intensive care?
- Natriuretic peptide testing in primary care patients
- Natriuretic peptide testing in emergency settings
- Minireviews
- Oxidative stress, free radicals and bone remodeling
- Plasma homocysteine and vascular disease in elderly patients with mental illness
- Opinion Papers
- Fate of abstracts presented at the 2002 IFCC meeting
- Transition from congress abstract to full paper: the case of a national Argentinean congress in clinical laboratory
- Genetics and Molecular Diagnostics
- Association of endothelin-1 gene polymorphisms with variant angina in Korean patients
- Single nucleotide polymorphisms in ABCG5 and ABCG8 genes in Chilean subjects with polygenic hypercholesterolemia and controls
- Paternal exclusion: allele sharing in microsatellite testing
- General Clinical Chemistry
- Rapid sample preparation and simultaneous quantitation of prostaglandins and lipoxygenase derived fatty acid metabolites by liquid chromatography-mass spectrometry from small sample volumes
- Plasma bilirubin correlations in non-obstructive cholestasis after partial hepatectomy
- Aggregation of lipoprotein and inflammatory parameters in families with a history of premature myocardial infarction: the Tallinn Myocardial Infarction Study
- Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease
- Hemoglobin A1c determination in the A1C-Derived Average Glucose (ADAG) study
- The effect of the mode of delivery on maternal-neonatal interleukin-6, biogenic amine and their precursor amino acid concentrations
- A rapid liquid chromatography-tandem mass spectrometry analysis of whole blood sirolimus using turbulent flow technology for online extraction
- Validation and Outcome Studies
- Benefits of the iQ200 automated urine microscopy analyser in routine urinalysis
- Electrochemical detection of blood alcohol concentration using a disposable biosensor based on screen-printed electrode modified with Nafion and gold nanoparticles
- About the z-multiplier in total error calculations
- Letters to the Editor
- A hypothyroid patient with increased free thyroid hormones
- Evaluation of blood collection tubes specific for homocysteine measurement
- Influence of assay-dependent variability of serum insulin levels on insulin sensitivity indices
- Frequency and type of preanalytical errors in a laboratory medicine department in India
- Sample dilution causes a positive bias on C-reactive protein using VITROS reagents, diluents and instruments – clinical implications?
Keywords for this article
automation;
detection;
iQ200;
microscopy;
urinalysis;
urinary tract pathology
Articles in the same Issue
- Editorial
- Biochemical markers in clinical cardiology: perspectives from present to future. 1st IFCC-Ortho Clinical Diagnostics Conference on Clinical Diagnosis and the Clinical Laboratory
- Highlight: Cardiovascular Biomarkers
- Reviews
- The clinical impact of the universal diagnosis of myocardial infarction
- Troponin revisited 2008: assay performance
- Standardization of troponin I measurements: an update
- Biochemistry of B-type natriuretic peptide – where are we now?
- Clinical relevance of non-cardiac determinants of natriuretic peptide levels
- What is the value of B-type natriuretic peptide testing for diagnosis, prognosis or monitoring of critically ill adult patients in intensive care?
- Natriuretic peptide testing in primary care patients
- Natriuretic peptide testing in emergency settings
- Minireviews
- Oxidative stress, free radicals and bone remodeling
- Plasma homocysteine and vascular disease in elderly patients with mental illness
- Opinion Papers
- Fate of abstracts presented at the 2002 IFCC meeting
- Transition from congress abstract to full paper: the case of a national Argentinean congress in clinical laboratory
- Genetics and Molecular Diagnostics
- Association of endothelin-1 gene polymorphisms with variant angina in Korean patients
- Single nucleotide polymorphisms in ABCG5 and ABCG8 genes in Chilean subjects with polygenic hypercholesterolemia and controls
- Paternal exclusion: allele sharing in microsatellite testing
- General Clinical Chemistry
- Rapid sample preparation and simultaneous quantitation of prostaglandins and lipoxygenase derived fatty acid metabolites by liquid chromatography-mass spectrometry from small sample volumes
- Plasma bilirubin correlations in non-obstructive cholestasis after partial hepatectomy
- Aggregation of lipoprotein and inflammatory parameters in families with a history of premature myocardial infarction: the Tallinn Myocardial Infarction Study
- Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease
- Hemoglobin A1c determination in the A1C-Derived Average Glucose (ADAG) study
- The effect of the mode of delivery on maternal-neonatal interleukin-6, biogenic amine and their precursor amino acid concentrations
- A rapid liquid chromatography-tandem mass spectrometry analysis of whole blood sirolimus using turbulent flow technology for online extraction
- Validation and Outcome Studies
- Benefits of the iQ200 automated urine microscopy analyser in routine urinalysis
- Electrochemical detection of blood alcohol concentration using a disposable biosensor based on screen-printed electrode modified with Nafion and gold nanoparticles
- About the z-multiplier in total error calculations
- Letters to the Editor
- A hypothyroid patient with increased free thyroid hormones
- Evaluation of blood collection tubes specific for homocysteine measurement
- Influence of assay-dependent variability of serum insulin levels on insulin sensitivity indices
- Frequency and type of preanalytical errors in a laboratory medicine department in India
- Sample dilution causes a positive bias on C-reactive protein using VITROS reagents, diluents and instruments – clinical implications?
