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Association of endothelin-1 gene polymorphisms with variant angina in Korean patients
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Juyong Lee
Published/Copyright:
November 1, 2008
Abstract
Background: The incidence of variant angina in oriental patients is higher than in patients from the Western world. Endothelin-1 (ET-1) seems to be associated with coronary vasospasm in variant angina, suggesting that ET-1 gene variants may be important in coronary vasospasm in variant angina. We wanted to assess potential association between Korean variant angina and three polymorphisms of the ET-1 gene, which include the +138delA polymorphism in exon 1, G8002A polymorphism in intron 4 and Lys198Asn polymorphism in exon 5.
Method: A total of 97 patients with variant angina and 111 healthy controls were studied. Analyses of the +138delA, G8002A and Lys198Asn polymorphisms were carried out by polymerase chain reaction-restriction fragment length polymorphism and haplotype techniques.
Results: The frequency of mutant 138delA allele was lower in the angina group than in controls [p=0.003, odds ratio (OR)=0.42] and the frequencies of A8002 or Asn198 were significantly higher in the variant angina group than in controls (p=0.005, OR=2.17 or p=0.009, OR=1.75, respectively). According to haplotype analysis, 4A/A8002/Asn198 haplotype was significantly associated with the disease (p=0.0162, OR=2.33) and 3A/G8002/Lys198 haplotype was protective against the disease (p=0.0043, OR=0.54).
Conclusions: The ET-1 gene polymorphisms, such as +138delA, G8002A and Lys198Asn polymorphisms, seem to be associated with variant angina in Korean patients.
Clin Chem Lab Med 2008;46:1575–80.
Keywords: +138delA polymorphism; endothelin-1; G8002A polymorphism; Lys198Asn polymorphism; variant angina
Received: 2008-4-22
Accepted: 2008-7-11
Published Online: 2008-11-01
Published in Print: 2008-11-01
©2008 by Walter de Gruyter Berlin New York
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Keywords for this article
+138delA polymorphism;
endothelin-1;
G8002A polymorphism;
Lys198Asn polymorphism;
variant angina
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- Biochemical markers in clinical cardiology: perspectives from present to future. 1st IFCC-Ortho Clinical Diagnostics Conference on Clinical Diagnosis and the Clinical Laboratory
- Highlight: Cardiovascular Biomarkers
- Reviews
- The clinical impact of the universal diagnosis of myocardial infarction
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- Standardization of troponin I measurements: an update
- Biochemistry of B-type natriuretic peptide – where are we now?
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