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Hematological parameters in preterm infants from birth to 16 weeks of age with reference to iron balance

  • Enni Mäkelä , Timo I. Takala , Pauli Suominen , Jaakko Matomäki , Toivo T. Salmi , Allan Rajamäki , Helena Lapinleimu , Liisa Lehtonen , Kerttu Irjala and Päivi M. Lähteenmäki
Published/Copyright: April 1, 2008
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Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 46 Issue 4

Abstract

Background: The objective of this study was to describe the natural kinetics of serum soluble transferrin receptor (S-TfR), ferritin and reticulocyte indices in preterm neonates, and to find out whether these analytes relate to hematocrit (Hct) level in determining the need for red cell (RBC) transfusions.

Methods: During a 2-year period, 100 preterm neonates were recruited in a tertiary level neonatal intensive care unit. Inclusion criteria were gestational age ≤34 weeks or birth weight <2000 g. Biochemical markers of iron deficiency and hematological indices were serially analyzed from birth. This report focuses on the first 16 weeks after birth.

Results: The trends of the studied analytes were presented with reference ranges. RBC transfusions did not have a significant effect on reticulocyte hemoglobin content (CHr) or reticulocyte count. Reticulocytes were lowest after the first week and S-TfR at 9 weeks of age. CHr and fraction of immature reticulocytes were highest at birth and decreased thereafter. CHr and reticulocyte count were significantly different in two groups determined by Hct level (Hct < or ≥0.30). This difference was not observed in S-TfR or ferritin concentrations.

Conclusions: In addition to reflecting the activity of erythropoiesis, S-TfR seems to reflect iron balance in preterm neonates. By using CHr and reticulocyte, it is possible to obtain more information about iron balance in relation to erythropoiesis, and it might be useful to combine this information with Hct before making a decision about a transfusion.

Clin Chem Lab Med 2008;46:551–7.

Keywords: anemia; iron deficiency; premature neonate; red cell transfusion; reticulocyte; transferrin receptor
Corresponding author: Päivi M. Lähteenmäki, MD, PhD, Department of Pediatrics, Turku University Hospital, PO BOX 52, 20521 Turku, Finland Phone: +358-2-3130000, Fax: +358-2-3132416,
Received: 2007-9-18
Accepted: 2007-12-18
Published Online: 2008-04-01
Published in Print: 2008-04-01

©2008 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2008.109
Keywords for this article
anemia; iron deficiency; premature neonate; red cell transfusion; reticulocyte; transferrin receptor

Articles in the same Issue

  1. Editorial
  2. Improving clinicians understanding of lipoprotein sub-fractions through new technology
  3. Review
  4. Free fatty acids as a cardiovascular risk factor
  5. Opinion Papers
  6. Pharmacy-based laboratory services: past or future and risk or opportunity?
  7. Standards of practice and uniformity in references style
  8. Genetics and Molecular Diagnostics
  9. Glutathione S-transferase variants increase susceptibility for late-onset Alzheimer's disease: association study and relationship with apolipoprotein E ɛ4 allele
  10. The D allele of angiotensin I-converting enzyme gene insertion/deletion polymorphism is associated with the severity of atherosclerosis
  11. The apolipoprotein A5 gene –1131T→C polymorphism affects vitamin E plasma concentrations in type 2 diabetic patients
  12. Cell lines that express membrane-associated DNA for anti-DNA antibody detection
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  14. Caspase-3 gene transfected with LIGHT gene: can it be used for therapy of human hepatocellular carcinoma?
  15. Performance characteristics of a real-time RT-PCR assay for quantification of hepatitis C virus RNA in patients with genotype 1 and 2 infections
  16. Apolipoprotein E polymorphisms in Mexican patients with coronary artery disease
  17. A new single nucleotide polymorphism genotyping method based on gap ligase chain reaction and a microsphere detection assay
  18. General Clinical Chemistry and Laboratory Medicine
  19. PROCAM Study: risk prediction for myocardial infarction using microfluidic high-density lipoprotein (HDL) subfractionation is independent of HDL cholesterol
  20. Evaluation of oxidative stress and inflammation in obese adults with metabolic syndrome
  21. Sex differences in adenosine deaminase activity of stroke patients
  22. Serum levels of the osteoprotegerin, receptor activator of nuclear factor κ-B ligand, metalloproteinase-1 (MMP-1) and tissue inhibitors of MMP-1 levels are increased in men 6 months after acute myocardial infarction
  23. Gelatinase matrix metalloproteinase (MMP)-2 and MMP-9 of the umbilical cord blood in preeclampsia
  24. Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
  25. Carbonylation of platelet proteins occurs as consequence of oxidative stress and thrombin activation, and is stimulated by ageing and type 2 diabetes
  26. An automated assay of urinary alanine aminopeptidase activity
  27. Non-high-density lipoprotein cholesterol levels and recent involuntary weight gain among asymptomatic female subjects
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  29. Reference intervals for circulating angiogenic cytokines
  30. Hematological parameters in preterm infants from birth to 16 weeks of age with reference to iron balance
  31. Influence of hydroxyethyl starch (6% HES 130/0.4) administration on hematology and clinical chemistry parameters
  32. Letters to the Editor
  33. Eosinophilic cationic protein in bronchoalveolar lavage fluid of lung transplant patients
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  35. Reply to Dr. Park's letter
  36. IFCC Guidelines and Recommendations
  37. Enzymatic assays for creatinine: time for action
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  41. Seventh International Symposium on Molecular Diagnostics Graz, Austria, May 22–24, 2008
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