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Non-high-density lipoprotein cholesterol levels and recent involuntary weight gain among asymptomatic female subjects

  • Kazuhiko Kotani , Hisashi Shimohiro , Seiji Adachi and Naoki Sakane
Published/Copyright: February 26, 2008
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Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 46 Issue 4

Abstract

Background: Serum non-high-density lipoprotein cholesterol (HDL-C), an easily identifiable atherogenic index, has attracted attention within a clinical meaning different from that of other lipid indexes. The link between body weight gain and the occurrence of cardiovascular diseases may be mediated through non-HDL-C. However, there have been few reports examining the independent associations between weight gain and non-HDL-C, over a period of at least 1 year, especially in females.

Methods: We examined data on 200 asymptomatic Japanese females (mean 49.1 years) with an involuntary weight gain of at least ≥0.1 kg/m2 as a body mass index (BMI) 1 year after a baseline check-up. At baseline and after the 1-year period, we measured BMI, blood pressure (BP) and blood metabolic variables, including non-HDL-C.

Results: The mean BMI levels rose from 22.9 to 23.5 kg/m2 during this period. Non-HDL-C levels had a significant increase (from 3.87 to 3.93 mmol/L), and a partial correlation test, adjusted for age and all measured metabolic variables, revealed that BMI change was significantly and independently correlated to non-HDL-C levels (r=0.25, p<0.0001), along with systolic BP. The subgroup with an age of <50 years had a clear correlation between BMI change and non-HDL-C levels (r=0.34, p=0.001), contrary to those of ≥50 years.

Conclusions: A short-term involuntary weight gain was significantly and independently correlated to an increase in non-HDL-C levels among asymptomatic Japanese females, particularly in relatively young subjects. In achieving a more favorable lipid profile of non-HDL-C, even a modest weight gain may need attention.

Clin Chem Lab Med 2008;46:541–4.

Keywords: body mass index; lipid; systolic blood pressure; weight change
Corresponding author: Kazuhiko Kotani, MD, PhD, Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan Phone: +81-859-38-6113, Fax: +81-859-38-6110,
Received: 2007-11-7
Accepted: 2007-12-8
Published Online: 2008-02-26
Published in Print: 2008-04-01

©2008 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2008.095
Keywords for this article
body mass index; lipid; systolic blood pressure; weight change

Articles in the same Issue

  1. Editorial
  2. Improving clinicians understanding of lipoprotein sub-fractions through new technology
  3. Review
  4. Free fatty acids as a cardiovascular risk factor
  5. Opinion Papers
  6. Pharmacy-based laboratory services: past or future and risk or opportunity?
  7. Standards of practice and uniformity in references style
  8. Genetics and Molecular Diagnostics
  9. Glutathione S-transferase variants increase susceptibility for late-onset Alzheimer's disease: association study and relationship with apolipoprotein E ɛ4 allele
  10. The D allele of angiotensin I-converting enzyme gene insertion/deletion polymorphism is associated with the severity of atherosclerosis
  11. The apolipoprotein A5 gene –1131T→C polymorphism affects vitamin E plasma concentrations in type 2 diabetic patients
  12. Cell lines that express membrane-associated DNA for anti-DNA antibody detection
  13. Certification of reference materials for detection of the human prothrombin gene G20210A sequence variant
  14. Caspase-3 gene transfected with LIGHT gene: can it be used for therapy of human hepatocellular carcinoma?
  15. Performance characteristics of a real-time RT-PCR assay for quantification of hepatitis C virus RNA in patients with genotype 1 and 2 infections
  16. Apolipoprotein E polymorphisms in Mexican patients with coronary artery disease
  17. A new single nucleotide polymorphism genotyping method based on gap ligase chain reaction and a microsphere detection assay
  18. General Clinical Chemistry and Laboratory Medicine
  19. PROCAM Study: risk prediction for myocardial infarction using microfluidic high-density lipoprotein (HDL) subfractionation is independent of HDL cholesterol
  20. Evaluation of oxidative stress and inflammation in obese adults with metabolic syndrome
  21. Sex differences in adenosine deaminase activity of stroke patients
  22. Serum levels of the osteoprotegerin, receptor activator of nuclear factor κ-B ligand, metalloproteinase-1 (MMP-1) and tissue inhibitors of MMP-1 levels are increased in men 6 months after acute myocardial infarction
  23. Gelatinase matrix metalloproteinase (MMP)-2 and MMP-9 of the umbilical cord blood in preeclampsia
  24. Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
  25. Carbonylation of platelet proteins occurs as consequence of oxidative stress and thrombin activation, and is stimulated by ageing and type 2 diabetes
  26. An automated assay of urinary alanine aminopeptidase activity
  27. Non-high-density lipoprotein cholesterol levels and recent involuntary weight gain among asymptomatic female subjects
  28. Reference Values
  29. Reference intervals for circulating angiogenic cytokines
  30. Hematological parameters in preterm infants from birth to 16 weeks of age with reference to iron balance
  31. Influence of hydroxyethyl starch (6% HES 130/0.4) administration on hematology and clinical chemistry parameters
  32. Letters to the Editor
  33. Eosinophilic cationic protein in bronchoalveolar lavage fluid of lung transplant patients
  34. Simple human error in data reading and expression in clinical chemistry
  35. Reply to Dr. Park's letter
  36. IFCC Guidelines and Recommendations
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  38. Implementation of standardization of HbA1c measurement Summary of the meeting with manufacturers held in Milan, Italy, December 12, 2007
  39. Abstracts
  40. 3rd International Conference on Dipeptidyl Peptidase and Related Proteins Antwerp, Belgium, April 23–25, 2008
  41. Seventh International Symposium on Molecular Diagnostics Graz, Austria, May 22–24, 2008
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