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Limits of usual biochemical alcohol markers in cord blood at term: a fetal/maternal population-based study
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Denis Gallot
Published/Copyright:
April 17, 2007
Abstract
Background: After maternal alcohol consumption during pregnancy, many neonates affected by less apparent forms of fetal alcohol syndrome disorder (FASD) do not receive proper diagnosis or treatment. There is thus a need for laboratory markers for early detection of alcohol-exposed neonates. The aim of our study was to assess the efficiency of the usual alcohol biomarkers measured in cord blood to identify alcohol-exposed neonates immediately after birth.
Methods: A 1-year study was conducted in the labor wards of the maternity units of the Auvergne, Central France at the time of term delivery. The patients answered an anonymous self-completion survey concerning alcohol use (Alcohol Use Disorder Identification Test; AUDIT) during their pregnancy. Aspartate aminotransferase, alanine aminotransferase, and γ-glutamyltransferase concentrations and the percentage of carbohydrate-deficient transferrin were measured in maternal and cord blood.
Results: We collected 870 maternal-fetal sample pairs. Two cases (0.2%) of typical FASD were detected. We report a non-significant correlation between maternal and cord blood biomarkers. None of the cord blood biomarkers differed significantly between newborns of alcohol-exposed and unexposed mothers.
Conclusions: We demonstrate that the usual alcohol biomarkers are not effective in cord blood for identifying alcohol-exposed neonates.
Clin Chem Lab Med 2007;45:546–8.
Keywords: alcohol; Alcohol Use Disorder Identification Test (AUDIT); carbohydrate-deficient transferrin; fetal alcohol syndrome disorder; pregnancy
Received: 2006-11-7
Accepted: 2007-1-4
Published Online: 2007-04-17
Published in Print: 2007-04-01
©2007 by Walter de Gruyter Berlin New York
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Keywords for this article
alcohol;
Alcohol Use Disorder Identification Test (AUDIT);
carbohydrate-deficient transferrin;
fetal alcohol syndrome disorder;
pregnancy
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