Article
Licensed
Unlicensed
Requires Authentication
Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPARγ-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population
-
Reza Meshkani
Published/Copyright:
April 17, 2007
Abstract
Background: The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPARγ-2) gene has been variably associated with insulin resistance, obesity and type 2 diabetes in several populations. However, this association has not been studied in Iranian subjects and we hypothesized that this variation might be associated with insulin resistance, type 2 diabetes and related metabolic traits in this population.
Methods: The Pro12Ala genotypes were determined by PCR-restriction fragment length polymorphism in 696 unrelated subjects including 412 non-diabetic controls and 284 type 2 diabetic patients.
Results: The frequency of the Ala allele was 9.4% and 5.9% in controls and type 2 diabetic subjects, respectively [adjusted odds ratio (OR) 0.457, p=0.005]. The Ala allele did not show a significant effect on anthropometric and biochemical parameters in the type 2 diabetic group, whereas in non-diabetic subjects, carriers of the Ala allele had significantly lower fasting insulin (p=0.007) and homeostasis model assessment of insulin resistance (HOMA-IR) (p=0.009) levels compared to Pro/Pro subjects. Multivariate logistic regression analysis showed that Pro12Ala polymorphism was an independent determinant of type 2 diabetes in this population.
Conclusions: Our results for a sample of Iranian type 2 diabetes cases and controls provide evidence that the Pro/Ala genotype of the PPARγ-2 gene is associated with insulin sensitivity and may also have protective role against type 2 diabetes.
Clin Chem Lab Med 2007;45:477–82.
Keywords: insulin resistance; Iranian population; obesity; peroxisome proliferator-activated receptor-γ2 (PPARγ-2); Pro12Ala; type 2 diabetes
Received: 2006-11-15
Accepted: 2007-1-13
Published Online: 2007-04-17
Published in Print: 2007-04-01
©2007 by Walter de Gruyter Berlin New York
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Electrophoretic separations of cerebrospinal fluid proteins in clinical investigations
- Haemophilia A: molecular insights
- Quality specifications: self pleasure for clinical laboratories or added value for patient management?
- A724A polymorphism of sarco(endo)plasmic reticulum Ca2+-ATPase 2 (SERCA2) in hypertensive patients
- Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis risk
- Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPARγ-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population
- A novel frameshift mutation of the lecithin:cholesterol acyltransferase (LCAT) gene associated with renal failure in familial LCAT deficiency
- The c.–292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective
- The genetic polymorphisms of β3-adrenergic receptor (AR) Trp64Arg and β2-AR Gln27Glu are associated with obesity in Chinese male hypertensive patients
- Diagnostic performance of combined specific urinary proteins and urinary flow cytometry in urinary tract pathology
- Diagnostic accuracy of the FIDIS multiplex fluorescent microsphere immunodetection system for anti-extractable nuclear antigen (ENA) antibodies in connective tissue diseases
- Fluorimetric quantitation of citalopram and escitalopram in plasma: developing an express method to monitor compliance in clinical trials
- Free serum cortisol: quantification applying equilibrium dialysis or ultrafiltration and an automated immunoassay system
- Percutaneous coronary intervention-induced variations in systemic parameters of inflammation: relationship with the mode of stenting
- Multicentre physiological reference values for the concentration of creatininium in plasma and diagnostic specificity of glomerular filtration rate estimated with the MDRD equation
- Serum levels of ischemia-modified albumin in healthy volunteers after exercise-induced calf-muscle ischemia
- Reference intervals for follicle-stimulating hormone, luteinizing hormone and prolactin in children and young adults on the bioMérieux Mini-Vidas system
- Limits of usual biochemical alcohol markers in cord blood at term: a fetal/maternal population-based study
- Implementing the Stockholm Conference hierarchy of objective quality criteria in a routine laboratory
- The diffusion of innovations theory could help laboratorians in research translation
- Detection of CYP2D6 polymorphisms *9, *10, and *41 using ARMS-PCR and their allelic frequencies in 400 psychiatric patients
- Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: I. Analyte definition and proposal of a candidate reference method
- Measurement of free thyroxine in laboratory medicine – proposal of measurand definition
Keywords for this article
insulin resistance;
Iranian population;
obesity;
peroxisome proliferator-activated receptor-γ2 (PPARγ-2);
Pro12Ala;
type 2 diabetes
Articles in the same Issue
- Electrophoretic separations of cerebrospinal fluid proteins in clinical investigations
- Haemophilia A: molecular insights
- Quality specifications: self pleasure for clinical laboratories or added value for patient management?
- A724A polymorphism of sarco(endo)plasmic reticulum Ca2+-ATPase 2 (SERCA2) in hypertensive patients
- Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis risk
- Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPARγ-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population
- A novel frameshift mutation of the lecithin:cholesterol acyltransferase (LCAT) gene associated with renal failure in familial LCAT deficiency
- The c.–292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective
- The genetic polymorphisms of β3-adrenergic receptor (AR) Trp64Arg and β2-AR Gln27Glu are associated with obesity in Chinese male hypertensive patients
- Diagnostic performance of combined specific urinary proteins and urinary flow cytometry in urinary tract pathology
- Diagnostic accuracy of the FIDIS multiplex fluorescent microsphere immunodetection system for anti-extractable nuclear antigen (ENA) antibodies in connective tissue diseases
- Fluorimetric quantitation of citalopram and escitalopram in plasma: developing an express method to monitor compliance in clinical trials
- Free serum cortisol: quantification applying equilibrium dialysis or ultrafiltration and an automated immunoassay system
- Percutaneous coronary intervention-induced variations in systemic parameters of inflammation: relationship with the mode of stenting
- Multicentre physiological reference values for the concentration of creatininium in plasma and diagnostic specificity of glomerular filtration rate estimated with the MDRD equation
- Serum levels of ischemia-modified albumin in healthy volunteers after exercise-induced calf-muscle ischemia
- Reference intervals for follicle-stimulating hormone, luteinizing hormone and prolactin in children and young adults on the bioMérieux Mini-Vidas system
- Limits of usual biochemical alcohol markers in cord blood at term: a fetal/maternal population-based study
- Implementing the Stockholm Conference hierarchy of objective quality criteria in a routine laboratory
- The diffusion of innovations theory could help laboratorians in research translation
- Detection of CYP2D6 polymorphisms *9, *10, and *41 using ARMS-PCR and their allelic frequencies in 400 psychiatric patients
- Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: I. Analyte definition and proposal of a candidate reference method
- Measurement of free thyroxine in laboratory medicine – proposal of measurand definition
