Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
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Ángela Casado
Abstract
Background: It has been suggested that an increase in oxidative stress in individuals with Down syndrome (DS) may cause adverse effects in the cell membranes through the oxidation of polyunsatured fatty acids.
Methods: We examined erythrocyte malondialdehyde (MDA) levels in 100 individuals of both sexes (34 males and 66 females) with DS, aged from newborn to 29 years. The cytogenetic analysis revealed 90 individuals with regular trisomy 21, four individuals with trisomy 21 by Robertsonian (Rb) translocation, and six individuals with mosaic trisomy 21. DS individuals were divided into six age groups. The control group consisted of 100 healthy individuals of both sexes (40 males and 60 females) who were age-matched with DS subjects.
Results: No significant differences were found in erythrocyte MDA levels between the sexes in any of the age groups for the DS group and the control group. We confirmed significantly higher erythrocyte levels of MDA in individuals with DS compared to the control group. A significant difference was observed in erythrocyte MDA levels between DS individuals with trisomy and controls for all age groups, and in individuals with DS due to Rb translocation trisomy. However, in DS individuals with mosaicism, MDA levels depended on the percentage of diploid and trisomy cells.
Conclusions: Our results confirm an increase in lipid peroxidation in patients with DS.
Clin Chem Lab Med 2007;45:59–62.
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©2007 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- CCLM: Bringing advances in laboratory medicine to the “New World”
- Diagnostic approach to inherited bleeding disorders
- Linking laboratory and medication data: new opportunities for pharmacoepidemiological research
- Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area
- Anti-thyroid-stimulating hormone receptor antibodies determined by second-generation assay
- Serum levels of granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) in pancreatic cancer patients
- Surrogate markers of insulin resistance in assessing individuals with new categories “prehypertension” and “prediabetes”
- Evaluation of pre-analytical, demographic, behavioural and metabolic variables on fibrinolysis and haemostasis activation markers utilised to assess hypercoagulability
- Hyperhomocysteinaemia and immune activation in patients with cancer
- The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers
- Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
- Pregnancy-associated plasma protein A in dialysis patients
- L-Cysteine supplementation prevents exercise-induced alterations in human erythrocyte membrane acetylcholinesterase and Na+,K+-ATPase activities
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- Interchangeability of measurements of CA 19-9 in serum with four frequently used assays: an update
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- Validation of an automated sensitive immunoassay for quantitation of cytokines in the sputum of cystic fibrosis patients
- Strong interference of hemoglobin concentration on CSF total protein measurement using the trichloroacetic acid precipitation method
- Correction of patient results for Beckman Coulter LX-20 assays affected by interference due to hemoglobin, bilirubin or lipids: a practical approach
- Acquiring a measurement system within the framework of standard ISO 15189
- Six Sigma and laboratory consultation
- ESR or LSRB, that is the question!
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