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Linking laboratory and medication data: new opportunities for pharmacoepidemiological research

  • Maarten J. ten Berg , Albert Huisman , Patricia M.L.A. van den Bemt , Alfred F.A.M. Schobben , Antoine C.G. Egberts and Wouter W. van Solinge
Published/Copyright: January 24, 2007
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Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 45 Issue 1

Abstract

Transfer of automated laboratory data collected during routine clinical care from the laboratory information system into a database format that enables linkage to other administrative (e.g., patient characteristics) or clinical (e.g., medication, diagnoses, procedures) data provides a valuable tool for clinical epidemiological research. It allows the investigation of biochemical characteristics of diseases, therapeutic effects and diagnostic and/or prognostic markers for disease with easy access and at relatively low cost. To this end, the Utrecht Patient Oriented Database (UPOD), an infrastructure of relational databases comprising data on patient characteristics, laboratory test results, medication orders, hospital discharge diagnoses and medical procedures for all patients treated at the University Medical Centre Utrecht since January 2004, was established. Current research within UPOD is focused on the innovative linkage of laboratory and medication data, which, for example, makes it possible to assess the quality of pharmacotherapy in clinical practice, to investigate interference between laboratory tests and drugs, to study the risk of adverse drug reactions, and to develop diagnostic and prognostic markers or algorithms for adverse drug reactions. Although recently established, we believe that UPOD broadens the opportunities for clinical pharmacoepidemiological research and can contribute to patient care from a laboratory perspective.

Clin Chem Lab Med 2007;45:13–9.

Keywords: clinical chemistry; clinical epidemiology; laboratory medicine; pharmacoepidemiology; research database
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Corresponding author: Wouter W. van Solinge, Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, P.O. Box 80.082, 3508TB Utrecht, The Netherlands Phone: +31-30-2507604, Fax: +31-30-2505418,

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Published Online: 2007-01-24
Published in Print: 2007-01-01

©2007 by Walter de Gruyter Berlin New York

Articles in the same Issue

  1. CCLM: Bringing advances in laboratory medicine to the “New World”
  2. Diagnostic approach to inherited bleeding disorders
  3. Linking laboratory and medication data: new opportunities for pharmacoepidemiological research
  4. Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area
  5. Anti-thyroid-stimulating hormone receptor antibodies determined by second-generation assay
  6. Serum levels of granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) in pancreatic cancer patients
  7. Surrogate markers of insulin resistance in assessing individuals with new categories “prehypertension” and “prediabetes”
  8. Evaluation of pre-analytical, demographic, behavioural and metabolic variables on fibrinolysis and haemostasis activation markers utilised to assess hypercoagulability
  9. Hyperhomocysteinaemia and immune activation in patients with cancer
  10. The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers
  11. Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
  12. Pregnancy-associated plasma protein A in dialysis patients
  13. L-Cysteine supplementation prevents exercise-induced alterations in human erythrocyte membrane acetylcholinesterase and Na+,K+-ATPase activities
  14. Assessment of homocysteine, neopterin and nitric oxide levels in Behcet's disease
  15. Increased adenosine deaminase in hydatidiform mole
  16. Classification tree analysis for the discrimination of pleural exudates and transudates
  17. External quality assessment of hemoglobin A2 measurement: data from an Italian pilot study with fresh whole blood samples and commercial HPLC systems
  18. Comparison of four commercial quantitative HIV-1 assays for viral load monitoring in clinical daily routine
  19. Interchangeability of measurements of CA 19-9 in serum with four frequently used assays: an update
  20. Analytical validation of the new version of the Liaison N-Tact PTH assay
  21. Validation of an automated sensitive immunoassay for quantitation of cytokines in the sputum of cystic fibrosis patients
  22. Strong interference of hemoglobin concentration on CSF total protein measurement using the trichloroacetic acid precipitation method
  23. Correction of patient results for Beckman Coulter LX-20 assays affected by interference due to hemoglobin, bilirubin or lipids: a practical approach
  24. Acquiring a measurement system within the framework of standard ISO 15189
  25. Six Sigma and laboratory consultation
  26. ESR or LSRB, that is the question!
  27. Reply to the Letter written by Hardeman
  28. Natriuretic peptides. The hormones of the heart
https://doi.org/10.1515/CCLM.2007.009
Keywords for this article
clinical chemistry; clinical epidemiology; laboratory medicine; pharmacoepidemiology; research database

Articles in the same Issue

  1. CCLM: Bringing advances in laboratory medicine to the “New World”
  2. Diagnostic approach to inherited bleeding disorders
  3. Linking laboratory and medication data: new opportunities for pharmacoepidemiological research
  4. Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area
  5. Anti-thyroid-stimulating hormone receptor antibodies determined by second-generation assay
  6. Serum levels of granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) in pancreatic cancer patients
  7. Surrogate markers of insulin resistance in assessing individuals with new categories “prehypertension” and “prediabetes”
  8. Evaluation of pre-analytical, demographic, behavioural and metabolic variables on fibrinolysis and haemostasis activation markers utilised to assess hypercoagulability
  9. Hyperhomocysteinaemia and immune activation in patients with cancer
  10. The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers
  11. Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
  12. Pregnancy-associated plasma protein A in dialysis patients
  13. L-Cysteine supplementation prevents exercise-induced alterations in human erythrocyte membrane acetylcholinesterase and Na+,K+-ATPase activities
  14. Assessment of homocysteine, neopterin and nitric oxide levels in Behcet's disease
  15. Increased adenosine deaminase in hydatidiform mole
  16. Classification tree analysis for the discrimination of pleural exudates and transudates
  17. External quality assessment of hemoglobin A2 measurement: data from an Italian pilot study with fresh whole blood samples and commercial HPLC systems
  18. Comparison of four commercial quantitative HIV-1 assays for viral load monitoring in clinical daily routine
  19. Interchangeability of measurements of CA 19-9 in serum with four frequently used assays: an update
  20. Analytical validation of the new version of the Liaison N-Tact PTH assay
  21. Validation of an automated sensitive immunoassay for quantitation of cytokines in the sputum of cystic fibrosis patients
  22. Strong interference of hemoglobin concentration on CSF total protein measurement using the trichloroacetic acid precipitation method
  23. Correction of patient results for Beckman Coulter LX-20 assays affected by interference due to hemoglobin, bilirubin or lipids: a practical approach
  24. Acquiring a measurement system within the framework of standard ISO 15189
  25. Six Sigma and laboratory consultation
  26. ESR or LSRB, that is the question!
  27. Reply to the Letter written by Hardeman
  28. Natriuretic peptides. The hormones of the heart
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