Increased adenosine deaminase in hydatidiform mole
-
Yaprak Engin-Üstün
Abstract
Background: The aim of the current study was to investigate levels of adenosine deaminase in plasma of patients with hydatidiform mole.
Methods: Plasma adenosine deaminase levels were determined in 17 women with normal pregnant course, in 17 women with hydatidiform mole, and in 17 non-pregnant healthy volunteers.
Results: Mean adenosine deaminase activity in the hydatidiform mole group was 121.5±24.8 U/L, significantly higher than in the pregnant control (7.8±6.5 U/L; p<0.0001) and non-pregnant control groups (6.4±7.4 U/L; p<0.0001). A cutoff level of 40.5 U/L was found, with both sensitivity and specificity of 100%.
Conclusions: Adenosine deaminase may play a role in the development of hydatidiform mole.
Clin Chem Lab Med 2007;45:78–81.
References
1. Kim SJ, Bae SN, Kim JH, Kim CJ, Han KT, Chung JK, et al. Epidemiology and time trends of gestational trophoblastic disease in Korea. Int J Gynaecol Obstet1998;60:S33–8.10.1016/S0020-7292(98)80003-9Search in Google Scholar
2. Palmer JR. Advances in the epidemiology of gestational trophoblastic disease. J Reprod Med1994;39:155–62.Search in Google Scholar
3. Harma M, Harma M, Yurtseven S, Gungen N. Gestational trophoblastic disease in Sanliurfa, southeast Anatolia, Turkey. Eur J Gynaecol Oncol2005;26:306–8.Search in Google Scholar
4. Fox IH, Kelley WN. The role of adenosine deaminase and 2′-deoxyadenosine in mammalian cells. Annu Rev Biochem1978;47:655–86.10.1146/annurev.bi.47.070178.003255Search in Google Scholar
5. Fischer D, Martin B, Wayden V, Synderman R. A role of adenosine deaminase in human monocyte maturation. J Clin Invest1976;58:399–407.10.1172/JCI108484Search in Google Scholar
6. Galanti B, Nardiello S, Russo M, Fiorentino F. Increased lymphocyte adenosine deaminase in typhoid fever. Scand J Infect Dis1981;13:47–50.10.1080/00365548.1981.11690366Search in Google Scholar
7. Bhargava DK, Gupta M, Nijhawan S, Dasarathy S, Kushwaha AK. ADA in peritoneal tuberculosis: diagnostic value in ascitic fluid and serum. Tubercle1990;71:121–6.10.1016/0041-3879(90)90007-USearch in Google Scholar
8. Martínez-Hernández D, Arenas Barbero J, Jaqueti Aroca J, Pérez-Piqueras F, Santos Sancho J, Cosín Ochaitia J, et al. Adenosine deaminase, acquired immunodeficiency syndrome (AIDS), and hepatitis B infection. Clin Chem1992;38:162–3.10.1093/clinchem/38.1.162Search in Google Scholar
9. Sufrin G, Tritsch GL, Mittelman A, Murphy GP. Adenosine deaminase activity in patients with carcinoma of the bladder. J Urol1978;119:343–6.10.1016/S0022-5347(17)57486-8Search in Google Scholar
10. Tang RB, Ma CS, Dong JZ, Liu XP, Liu X. Does adenosine deaminase play a key role in coronary artery disease? Med Hypoth2006;67:371–4.10.1016/j.mehy.2006.01.038Search in Google Scholar PubMed
11. Giuisti G. Adenosine deaminase. In: Bergmeyer HU, editor. Methods of enzymatic analysis. New York: Academic Press, 1974:1092–8.Search in Google Scholar
12. Karabulut AB, Kafkasli A, Burak F, Gozukara EM. Maternal and fetal plasma adenosine deaminase, xanthine oxidase and malondialdehyde levels in preeclampsia. Cell Biochem Funct2005;23:279–83.10.1002/cbf.1152Search in Google Scholar PubMed
13. Wongweragiat S, Searle RF, Bulmer JN. Decidual T lymphocyte activation in hydatidiform mole. J Clin Pathol1999;52:888–94.10.1136/jcp.52.12.888Search in Google Scholar PubMed PubMed Central
14. Hostetter MK, Johnson GM. The erythrocyte instigator of inflammation: generation of amidated C3 by erythrocyte adenosine deaminase. J Clin Invest1989;84:665–71.10.1172/JCI114213Search in Google Scholar PubMed PubMed Central
15. Xia Y, Khatchikian G, Zweier JL. Adenosine deaminase inhibition prevents free radical-mediated injury in the post ischemic heart. J Biol Chem1996;271:10096–102.10.1074/jbc.271.17.10096Search in Google Scholar PubMed
16. Harma M, Harma M, Kocyigit A. Comparison of protein carbonyl and total plasma thiol concentrations in patients with complete hydatidiform mole with those in healthy pregnant women. Acta Obstet Gynecol Scand2004;83:857–60.10.1111/j.0001-6349.2004.00608.xSearch in Google Scholar PubMed
17. Harma M, Harma M. Defective placentation and resultant oxidative stress play a similar role in complete hydatidiform mole to that in preeclampsia and early pregnancy loss. Med Hypoth2006;66:100–2.10.1016/j.mehy.2005.07.029Search in Google Scholar PubMed
©2007 by Walter de Gruyter Berlin New York
Articles in the same Issue
- CCLM: Bringing advances in laboratory medicine to the “New World”
- Diagnostic approach to inherited bleeding disorders
- Linking laboratory and medication data: new opportunities for pharmacoepidemiological research
- Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area
- Anti-thyroid-stimulating hormone receptor antibodies determined by second-generation assay
- Serum levels of granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) in pancreatic cancer patients
- Surrogate markers of insulin resistance in assessing individuals with new categories “prehypertension” and “prediabetes”
- Evaluation of pre-analytical, demographic, behavioural and metabolic variables on fibrinolysis and haemostasis activation markers utilised to assess hypercoagulability
- Hyperhomocysteinaemia and immune activation in patients with cancer
- The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers
- Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
- Pregnancy-associated plasma protein A in dialysis patients
- L-Cysteine supplementation prevents exercise-induced alterations in human erythrocyte membrane acetylcholinesterase and Na+,K+-ATPase activities
- Assessment of homocysteine, neopterin and nitric oxide levels in Behcet's disease
- Increased adenosine deaminase in hydatidiform mole
- Classification tree analysis for the discrimination of pleural exudates and transudates
- External quality assessment of hemoglobin A2 measurement: data from an Italian pilot study with fresh whole blood samples and commercial HPLC systems
- Comparison of four commercial quantitative HIV-1 assays for viral load monitoring in clinical daily routine
- Interchangeability of measurements of CA 19-9 in serum with four frequently used assays: an update
- Analytical validation of the new version of the Liaison N-Tact PTH assay
- Validation of an automated sensitive immunoassay for quantitation of cytokines in the sputum of cystic fibrosis patients
- Strong interference of hemoglobin concentration on CSF total protein measurement using the trichloroacetic acid precipitation method
- Correction of patient results for Beckman Coulter LX-20 assays affected by interference due to hemoglobin, bilirubin or lipids: a practical approach
- Acquiring a measurement system within the framework of standard ISO 15189
- Six Sigma and laboratory consultation
- ESR or LSRB, that is the question!
- Reply to the Letter written by Hardeman
- Natriuretic peptides. The hormones of the heart
Articles in the same Issue
- CCLM: Bringing advances in laboratory medicine to the “New World”
- Diagnostic approach to inherited bleeding disorders
- Linking laboratory and medication data: new opportunities for pharmacoepidemiological research
- Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area
- Anti-thyroid-stimulating hormone receptor antibodies determined by second-generation assay
- Serum levels of granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) in pancreatic cancer patients
- Surrogate markers of insulin resistance in assessing individuals with new categories “prehypertension” and “prediabetes”
- Evaluation of pre-analytical, demographic, behavioural and metabolic variables on fibrinolysis and haemostasis activation markers utilised to assess hypercoagulability
- Hyperhomocysteinaemia and immune activation in patients with cancer
- The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers
- Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
- Pregnancy-associated plasma protein A in dialysis patients
- L-Cysteine supplementation prevents exercise-induced alterations in human erythrocyte membrane acetylcholinesterase and Na+,K+-ATPase activities
- Assessment of homocysteine, neopterin and nitric oxide levels in Behcet's disease
- Increased adenosine deaminase in hydatidiform mole
- Classification tree analysis for the discrimination of pleural exudates and transudates
- External quality assessment of hemoglobin A2 measurement: data from an Italian pilot study with fresh whole blood samples and commercial HPLC systems
- Comparison of four commercial quantitative HIV-1 assays for viral load monitoring in clinical daily routine
- Interchangeability of measurements of CA 19-9 in serum with four frequently used assays: an update
- Analytical validation of the new version of the Liaison N-Tact PTH assay
- Validation of an automated sensitive immunoassay for quantitation of cytokines in the sputum of cystic fibrosis patients
- Strong interference of hemoglobin concentration on CSF total protein measurement using the trichloroacetic acid precipitation method
- Correction of patient results for Beckman Coulter LX-20 assays affected by interference due to hemoglobin, bilirubin or lipids: a practical approach
- Acquiring a measurement system within the framework of standard ISO 15189
- Six Sigma and laboratory consultation
- ESR or LSRB, that is the question!
- Reply to the Letter written by Hardeman
- Natriuretic peptides. The hormones of the heart
