Evaluation of clinical markers of atherosclerosis in young and elderly Japanese adults
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Takanobu Hara
Abstract
Background: In order to be able to take preventative measures early in life against the development of atherosclerosis, it is important to evaluate profiles of subclinical atherosclerosis, especially among young adults.
Methods: We screened plasma homocysteine levels, highly sensitive C-reactive protein levels and carotid intima-media thickness in young and elderly adults.
Results: Among both young and elderly adults, plasma homocysteine and highly sensitive C-reactive protein were significantly lower in females than in males. Highly sensitive C-reactive protein was significantly lower in young adults than in elderly adults, and homocysteine was lower (but not significantly) in young adults than in elderly adults. Among young adults, mean carotid intima-media thickness was lower (but not significantly) in females than in males. Among elderly adults, mean carotid intima-media thickness was significantly lower in females than in males. Among both males and females, mean carotid intima-media thickness was significantly higher in elderly adults than in young adults.
Conclusions: These results demonstrate basic profiles of atherosclerosis markers in young and elderly Japanese adults. Further study is needed to evaluate measures developed for application in early adulthood to prevent atherosclerosis.
Clin Chem Lab Med 2006;44:824–9.
References
1. Misra A. Risk factors for atherosclerosis in young individuals. J Cardiovasc Risk 2000:215–29.10.1177/204748730000700309Search in Google Scholar PubMed
2. Markus RA, Mack WJ, Azen SP, Hodis HN. Influence of lifestyle modification on atherosclerotic progression determined by ultrasonographic change in the common carotid intima-media thickness. Am J Clin Nutr 1997; 65:1000–4.10.1093/ajcn/65.4.1000Search in Google Scholar PubMed
3. Oren A, Vos LE, Uiterwaal CS, Grobbee DE, Bots ML. Cardiovascular risk factors and increased carotid intima-media thickness in healthy young adults: the Atherosclerosis Risk in Young Adults (ARYA) Study. Arch Intern Med 2003; 163:1787–92.10.1001/archinte.163.15.1787Search in Google Scholar PubMed
4. De Bree A, Verschuren WM, Kromhout D, Kluijtmans LA, Blom HJ. Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev 2002; 54:599–618.10.1124/pr.54.4.599Search in Google Scholar PubMed
5. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. J Am Med Assoc 2002;288:2015–22.10.1001/jama.288.16.2015Search in Google Scholar PubMed
6. Durga J, Verhoef P, Bots ML, Schouten E. Homocysteine and carotid intima-media thickness: a critical appraisal of the evidence. Atherosclerosis 2004; 176:1–19.10.1016/j.atherosclerosis.2003.11.022Search in Google Scholar PubMed
7. Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999; 19:217–46.10.1146/annurev.nutr.19.1.217Search in Google Scholar PubMed
8. Homocysteine Lowering Trialists' Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Br Med J 1998;316:894–8.10.1136/bmj.316.7135.894Search in Google Scholar
9. Liuzzo G, Biasucci LM, Gallimore JR, Grillo RL, Rebuzzi AG, Pepys MB, et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med 1994; 331:417–24.10.1056/NEJM199408183310701Search in Google Scholar PubMed
10. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336:973–9.10.1056/NEJM199704033361401Search in Google Scholar PubMed
11. Haverkate F, Thompson SG, Pyke SD, Gallimore JR, Pepys MB. Production of C-reactive protein and risk of coronary events in stable and unstable angina. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Lancet 1997; 349:462–6.10.1016/S0140-6736(96)07591-5Search in Google Scholar
12. Reynolds GD, Vance RP. C-reactive protein immunohistochemical localization in normal and atherosclerotic human aortas. Arch Pathol Lab Med 1987; 111:265–9.Search in Google Scholar
13. Macy EM, Hayes TE, Tracy RP. Variability in the measurement of C-reactive protein in healthy subjects: implications for reference intervals and epidemiological applications. Clin Chem 1997; 43:52–8.10.1093/clinchem/43.1.52Search in Google Scholar
14. Mendall MA, Patel P, Ballam L, Strachan D, Northfield TC. C reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study. Br Med J 1996; 312:1061–5.10.1136/bmj.312.7038.1061Search in Google Scholar
15. Ridker PM. Inflammation, infection, and cardiovascular risk: how good is the clinical evidence? Circulation 1998; 97:1671–4.10.1161/01.CIR.97.17.1671Search in Google Scholar
16. Srinivasan SR, Ehnholm C, Wattigney WA, Berenson GS. Influence of apolipoprotein E polymorphism on the tracking of childhood levels of serum lipids and apolipoproteins over a 6-year period. The Bogalusa Heart Study. Atherosclerosis 1996; 127:73–9.10.1016/S0021-9150(96)05937-0Search in Google Scholar
17. Cook DG, Mendall MA, Whincup PH, Carey IM, Ballam L, Morris JE, et al. C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors. Atherosclerosis 2000; 149:139–50.10.1016/S0021-9150(99)00312-3Search in Google Scholar
18. Kimura Y, Takamura N, Fukunaga M, Kanagae M, Abe Y, Aoyagi K. Evaluation of high sensitive C-reactive protein and 5,10-methylenetetrahydrofolate reductase genotype in Japanese young adults. Biomarkers 2004; 9:291–7.10.1080/13547500400017846Search in Google Scholar
19. Chambless LE, Folsom AR, Clegg LX, Sharrett AR, Shahar E, Nieto FJ, et al. Carotid wall thickness is predictive of incident clinical stroke: the Atherosclerosis Risk in Communities (ARIC) study. Am J Epidemiol 2000; 151:478–87.10.1093/oxfordjournals.aje.a010233Search in Google Scholar
20. Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997; 96:1432–7.10.1161/01.CIR.96.5.1432Search in Google Scholar
21. Garcia AJ, Apitz-Castro R. Plasma total homocysteine quantification: an improvement of the classical high-performance liquid chromatographic method with fluorescence detection of the thiol-SBD derivatives. J Chromatogr B 2002; 779:359–63.10.1016/S1570-0232(02)00401-4Search in Google Scholar
22. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. Br Med J 2002; 325:1202.10.1136/bmj.325.7374.1202Search in Google Scholar
23. Casas JP, Bautista LE, Smeeth L, Sharma P, Hingorani AD. Homocysteine and stroke: evidence on a causal link from Mendelian randomisation. Lancet 2005; 365:224–32.10.1016/S0140-6736(05)70152-5Search in Google Scholar
24. de Bree A, Verschuren WM, Blom HJ, Kromhout D. Lifestyle factors and plasma homocysteine concentrations in a general population sample. Am J Epidemiol 2001; 154:150–4.10.1093/aje/154.2.150Search in Google Scholar PubMed
25. Lussier-Cocan S, Xhignesse M, Piolot A, Selhub J, Davignon J. Plasma level homocysteine in healthy subjects: sex-specific relation with biological traits. Am J Clin Nutr 1996; 64:587–93.10.1093/ajcn/64.4.587Search in Google Scholar PubMed
26. Homma S, Hirose N, Ishida H, Ishii T, Araki G. Carotid plaque and intima-media thickness assessed by B-mode ultrasonography in subjects ranging from young adults to centenarians. Stroke 2001; 32:830–5.10.1161/01.STR.32.4.830Search in Google Scholar PubMed
©2006 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Flow-cytometric immunophenotyping of normal and malignant lymphocytes
- Recommendation to treat continuous variable errors like attribute errors
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- Use of total patient data for indirect estimation of reference intervals for 40 clinical chemical analytes in Turkey
- Use of haemolysis index to estimate potassium concentration in in-vitro haemolysed serum samples
- Longitudinal changes in serum paraoxonase-1 activity throughout normal pregnancy
- Establishment of detailed reference values for luteinizing hormone, follicle stimulating hormone, estradiol, and progesterone during different phases of the menstrual cycle on the Abbott ARCHITECT® analyzer
- Evaluation and quality assessment of glucose concentration measurement in blood by point-of-care testing devices
- Hypothesis on interferences in kinetic interaction of microparticles in solution (KIMS) technology
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- Transcriptions and ISO 15189
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Articles in the same Issue
- Flow-cytometric immunophenotyping of normal and malignant lymphocytes
- Recommendation to treat continuous variable errors like attribute errors
- Polymorphisms associated with apolipoprotein B levels in Greek patients with familial hypercholesterolemia
- Lack of association between α2B-adrenergic receptor polymorphism and risk of restenosis following coronary angioplasty and stent implantation – preliminary report
- Prognostic value of homocysteinemia in patients with congestive heart failure
- Comparability of indices for insulin resistance and insulin secretion determined during oral glucose tolerance tests
- Evaluation of clinical markers of atherosclerosis in young and elderly Japanese adults
- Hypoadiponectinemia is associated with symptomatic atherosclerotic peripheral arterial disease
- Cardiac troponin T and amino-terminal pro-natriuretic peptide concentrations in fetuses in the second trimester and in healthy neonates
- Autoantibody profiling of patients with autoimmune thyroid disease using a new multiplexed immunoassay method
- Fluorimetric determination of activity and isoenzyme composition of N-acetyl-β-D-hexosaminidase in seminal plasma of fertile men and infertile patients with secretory azoospermia
- Increased fructosamine in non-diabetic rheumatoid arthritis patients: role of lipid peroxides and glutathione
- Usefulness of whole blood aggregometry and its comparison with thromboxane generation assay in monitoring acetylsalicylic acid effectiveness – a multiparametric study in rats
- Elevated plasma homocysteine levels in L-dopa-treated Parkinson's disease patients with dyskinesias
- Use of total patient data for indirect estimation of reference intervals for 40 clinical chemical analytes in Turkey
- Use of haemolysis index to estimate potassium concentration in in-vitro haemolysed serum samples
- Longitudinal changes in serum paraoxonase-1 activity throughout normal pregnancy
- Establishment of detailed reference values for luteinizing hormone, follicle stimulating hormone, estradiol, and progesterone during different phases of the menstrual cycle on the Abbott ARCHITECT® analyzer
- Evaluation and quality assessment of glucose concentration measurement in blood by point-of-care testing devices
- Hypothesis on interferences in kinetic interaction of microparticles in solution (KIMS) technology
- Comparability of point-of-care whole-blood electrolyte and substrate testing using a Stat Profile Critical Care Xpress analyzer and standard laboratory methods
- Determination of the length of sedimentation reaction in blood using the TEST 1 system: comparison with the Sedimatic 100 method, turbidimetric fibrinogen levels, and the influence of M-proteins
- Transcriptions and ISO 15189
- Falsely elevated troponin I attributed to inadequate centrifugation using the Access® immunoassay analyzer
- Interference of sulfamethoxazole in Capillarys® electrophoresis
