Longitudinal changes in serum paraoxonase-1 activity throughout normal pregnancy
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Natàlia Ferré
Abstract
The aim of this study was to investigate the longitudinal changes in serum paraoxonase-1 (PON1) activity from preconception throughout normal pregnancy and their relationships with maternal dietary vitamin C and E intake. The study was performed in 35 women (studied at preconception, at 8, 20 and 32weeks of pregnancy, and at labour). PON1 activity decreased significantly from 145.8 (109.8–198.8) U/L at preconception to 111.1 (85.3–179.9) U/L (p<0.01) at 32weeks and 100.4 (54.7–171.4) U/L (p<0.001) at labour. There was a direct association between vitamin C intake and PON1 at week 32 (p=0.018). We conclude that adequate vitamin C intake in pregnant women may merit consideration, since vitamin C supplementation has proved beneficial in the prevention of preeclampsia in women at increased risk of this condition.
Clin Chem Lab Med 2006;44:880–2.
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©2006 by Walter de Gruyter Berlin New York
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- Lack of association between α2B-adrenergic receptor polymorphism and risk of restenosis following coronary angioplasty and stent implantation – preliminary report
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- Cardiac troponin T and amino-terminal pro-natriuretic peptide concentrations in fetuses in the second trimester and in healthy neonates
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- Evaluation and quality assessment of glucose concentration measurement in blood by point-of-care testing devices
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- Transcriptions and ISO 15189
- Falsely elevated troponin I attributed to inadequate centrifugation using the Access® immunoassay analyzer
- Interference of sulfamethoxazole in Capillarys® electrophoresis
