Interferon β1a Therapy Changes Lipoprotein Metabolism in Patients with Multiple Sclerosis
-
Armando Sena
Abstract
To assess whether interferon β1a (IFNβ1a) therapy affects plasma lipoprotein metabolism, twelve patients with relapsing-remitting multiple sclerosis (MS) were studied during a two-year follow-up period. High density lipoprotein (Hdl2) cholesterol and the Hdl2/Hdl3 ratio were increased at year 2 and lipoprotein (a) was transitorily increased at year 1, in comparison to baseline levels. Apolipoprotein A-I was lower and apolipoprotein E higher at year 1, only in a subgroup of patients who experienced relapses and/or progressed during therapy. These findings suggest that IFNβ1a treatment is associated with changes in the lipoprotein metabolism. Alterations in this metabolism could be related to the immunomodulatory actions of the drug and the disease activity in multiple sclerosis patients.
Copyright © 2000 by Walter de Gruyter GmbH & Co. KG
Artikel in diesem Heft
- Laboratory Diagnosis of Patients with Acute Chest Pain
- Methods for the Determination of Plasma Total Homocysteine: a Review
- Serum Protein 90K/Mac-2BP Is an Independent Predictor of Disease Severity during Hepatitis C Virus Infection
- Interferon β1a Therapy Changes Lipoprotein Metabolism in Patients with Multiple Sclerosis
- On-Line Analysis of Electrolytes in Extracorporeally Circulating Blood: Application of a Rat Model to Examine the Effect of a Single Pharma-cological Dose of Melatonin on Electrolyte Levels in Blood
- Biochemical and Hematological Changes in Low-Level Aluminum Intoxication
- On Accuracy and Precision of a HPLC Method for Measurement of Urine Porphyrin Concentrations
- Human Heart-Type Cytoplasmic Fatty Acid-Binding Protein (H-FABP) for the Diagnosis of Acute Myocardial Infarction. Clinical Evaluation of H-FABP in Comparison with Myoglobin and Creatine Kinase Isoenzyme MB
- Quality Control of Coated Antibodies: New, Rapid Determination of Binding Affinity
- Determination of Reticulocytes: Three Methods Compared
- A New Modular Chemiluminescence Immunoassay Analyser Evaluated
- Point-of-Care Testing
- Pre-Analytical Variation of Laboratory Variables
- Capillary Electrophoresis: Theory and Practice. P. Camilleri, editor
- Life, the Lab, and Everything. Ian Wilkinson
Artikel in diesem Heft
- Laboratory Diagnosis of Patients with Acute Chest Pain
- Methods for the Determination of Plasma Total Homocysteine: a Review
- Serum Protein 90K/Mac-2BP Is an Independent Predictor of Disease Severity during Hepatitis C Virus Infection
- Interferon β1a Therapy Changes Lipoprotein Metabolism in Patients with Multiple Sclerosis
- On-Line Analysis of Electrolytes in Extracorporeally Circulating Blood: Application of a Rat Model to Examine the Effect of a Single Pharma-cological Dose of Melatonin on Electrolyte Levels in Blood
- Biochemical and Hematological Changes in Low-Level Aluminum Intoxication
- On Accuracy and Precision of a HPLC Method for Measurement of Urine Porphyrin Concentrations
- Human Heart-Type Cytoplasmic Fatty Acid-Binding Protein (H-FABP) for the Diagnosis of Acute Myocardial Infarction. Clinical Evaluation of H-FABP in Comparison with Myoglobin and Creatine Kinase Isoenzyme MB
- Quality Control of Coated Antibodies: New, Rapid Determination of Binding Affinity
- Determination of Reticulocytes: Three Methods Compared
- A New Modular Chemiluminescence Immunoassay Analyser Evaluated
- Point-of-Care Testing
- Pre-Analytical Variation of Laboratory Variables
- Capillary Electrophoresis: Theory and Practice. P. Camilleri, editor
- Life, the Lab, and Everything. Ian Wilkinson
