Serum Protein 90K/Mac-2BP Is an Independent Predictor of Disease Severity during Hepatitis C Virus Infection
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Eva M. Kittl
Abstract
The serum protein designated 90K/Mac-2BP has been found at elevated concentrations in the sera of patients with various types of cancer and viral infections. The importance of the 90K/Mac-2BP serum concentrations in predicting the response towards interferon-α treatment for hepatitis C virus (HCV) infection prompted us to utilize a new ELISA for soluble human 90K/Mac-2BP to monitor the serum concentrations of this protein in our HCV-positive patients. Seventy HCV-PCR and anti-HCV antibody positive patients were analyzed for their serum levels of aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, cholinesterase, HCV-viral load, viral subtypes, and 90K/Mac-2BP. On correlation of age and 90K/Mac-2BP levels, we found an apparent correlation that was proved rather to be a strong dependence of 90K/Mac-2BP concentrations on disease severity/duration, which increases with age. Multiple correlation analysis demonstrated the independent nature of 90K/Mac-2BP concentrations, underscoring the potential high utility of this new marker. Our data corroborate the potential of the scavenger receptor family protein 90K/Mac-2BP as an independent predictor of disease severity during HCV infection.
Copyright © 2000 by Walter de Gruyter GmbH & Co. KG
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- Methods for the Determination of Plasma Total Homocysteine: a Review
- Serum Protein 90K/Mac-2BP Is an Independent Predictor of Disease Severity during Hepatitis C Virus Infection
- Interferon β1a Therapy Changes Lipoprotein Metabolism in Patients with Multiple Sclerosis
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- Biochemical and Hematological Changes in Low-Level Aluminum Intoxication
- On Accuracy and Precision of a HPLC Method for Measurement of Urine Porphyrin Concentrations
- Human Heart-Type Cytoplasmic Fatty Acid-Binding Protein (H-FABP) for the Diagnosis of Acute Myocardial Infarction. Clinical Evaluation of H-FABP in Comparison with Myoglobin and Creatine Kinase Isoenzyme MB
- Quality Control of Coated Antibodies: New, Rapid Determination of Binding Affinity
- Determination of Reticulocytes: Three Methods Compared
- A New Modular Chemiluminescence Immunoassay Analyser Evaluated
- Point-of-Care Testing
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Articles in the same Issue
- Laboratory Diagnosis of Patients with Acute Chest Pain
- Methods for the Determination of Plasma Total Homocysteine: a Review
- Serum Protein 90K/Mac-2BP Is an Independent Predictor of Disease Severity during Hepatitis C Virus Infection
- Interferon β1a Therapy Changes Lipoprotein Metabolism in Patients with Multiple Sclerosis
- On-Line Analysis of Electrolytes in Extracorporeally Circulating Blood: Application of a Rat Model to Examine the Effect of a Single Pharma-cological Dose of Melatonin on Electrolyte Levels in Blood
- Biochemical and Hematological Changes in Low-Level Aluminum Intoxication
- On Accuracy and Precision of a HPLC Method for Measurement of Urine Porphyrin Concentrations
- Human Heart-Type Cytoplasmic Fatty Acid-Binding Protein (H-FABP) for the Diagnosis of Acute Myocardial Infarction. Clinical Evaluation of H-FABP in Comparison with Myoglobin and Creatine Kinase Isoenzyme MB
- Quality Control of Coated Antibodies: New, Rapid Determination of Binding Affinity
- Determination of Reticulocytes: Three Methods Compared
- A New Modular Chemiluminescence Immunoassay Analyser Evaluated
- Point-of-Care Testing
- Pre-Analytical Variation of Laboratory Variables
- Capillary Electrophoresis: Theory and Practice. P. Camilleri, editor
- Life, the Lab, and Everything. Ian Wilkinson
