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Methods for the Determination of Plasma Total Homocysteine: a Review
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Maria Isabel Amores-Sánchez
Published/Copyright:
June 1, 2005
Abstract
Total homocysteine is the sum of all homocysteine species present in plasma. This parameter is valuable for the diagnosis and follow up of cobalamine or folate deficiencies, and it has been accepted as an independent risk factor for premature cardiovascular disease. These reasons justify the introduction of total homocysteine assays in the routine clinical laboratory. In the present review, we discuss the procedures for sample collection, processing and storage, and review the methodologies for measuring total homocysteine. We compare their feasibility as routine methods in the clinical laboratory.
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Published Online: 2005-06-01
Published in Print: 2000-03-25
Copyright (c)2000 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Laboratory Diagnosis of Patients with Acute Chest Pain
- Methods for the Determination of Plasma Total Homocysteine: a Review
- Serum Protein 90K/Mac-2BP Is an Independent Predictor of Disease Severity during Hepatitis C Virus Infection
- Interferon β1a Therapy Changes Lipoprotein Metabolism in Patients with Multiple Sclerosis
- On-Line Analysis of Electrolytes in Extracorporeally Circulating Blood: Application of a Rat Model to Examine the Effect of a Single Pharma-cological Dose of Melatonin on Electrolyte Levels in Blood
- Biochemical and Hematological Changes in Low-Level Aluminum Intoxication
- On Accuracy and Precision of a HPLC Method for Measurement of Urine Porphyrin Concentrations
- Human Heart-Type Cytoplasmic Fatty Acid-Binding Protein (H-FABP) for the Diagnosis of Acute Myocardial Infarction. Clinical Evaluation of H-FABP in Comparison with Myoglobin and Creatine Kinase Isoenzyme MB
- Quality Control of Coated Antibodies: New, Rapid Determination of Binding Affinity
- Determination of Reticulocytes: Three Methods Compared
- A New Modular Chemiluminescence Immunoassay Analyser Evaluated
- Point-of-Care Testing
- Pre-Analytical Variation of Laboratory Variables
- Capillary Electrophoresis: Theory and Practice. P. Camilleri, editor
- Life, the Lab, and Everything. Ian Wilkinson
