Startseite Assessment of spatial organization in the atria during paroxysmal atrial fibrillation and adrenergic stimulation
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Assessment of spatial organization in the atria during paroxysmal atrial fibrillation and adrenergic stimulation

  • Valentina D.A. Corino , Massimo Mantica , Federico Lombardi und Luca T. Mainardi
Veröffentlicht/Copyright: 25. Oktober 2006
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Biomedical Engineering / Biomedizinische Technik
Aus der Zeitschrift Band 51 Heft 4

Abstract

Non-linear parameters were computed to assess the extent of spatial organization in the atria in terms of coupling/synchronization between electrograms recorded in different atrial sites. Recordings of 9 patients suffering from paroxysmal atrial fibrillation were tested during four clinical experimental conditions: sinus rhythm and atrial fibrillation, both before and after isoproterenol infusion, a drug mimicking adrenergic activation. Two non-linear metrics were investigated: an index of non-linear association (NLA) and a synchronization (S) index based on the cross-conditional entropy. Results evidence the presence of reduced coupling after drug infusion in both sinus rhythm and atrial fibrillation. Moreover, passing from the NLA to the S index, the capability of the parameter to capture the subtle changes due to isoproterenol administration increased.


Corresponding author: Ing. Valentina D.A. Corino, Dipartimento di Bioingegneria, Politecnico di Milano, Via Golgi 39, 20133 Milano, Italy Phone: +39-02-2399-3374 Fax: +39-02-2399-3360

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Published Online: 2006-10-25
Published in Print: 2006-10-01

©2006 by Walter de Gruyter Berlin New York

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