Differences between heart rate and blood pressure variability in schizophrenia
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Karl-Jürgen Bär
, Michael K. Boettger and Andreas Voss
Abstract
Heart rate and blood pressure variability parameters were assessed to determine the risk of cardiac mortality in schizophrenia. We investigated 21 acute, unmedicated patients with paranoid schizophrenia and 21 matched controls. Cardiovascular parameters obtained included heart rate variability, blood pressure variability, cardiac output and left ventricular work index. All parameters investigated were analyzed using linear and non-linear techniques. These investigations revealed increased left ventricular work index and reduced heart rate variability. Furthermore, blood pressure was significantly higher compared to controls, whereas its variability was unchanged. We conclude that our results reflect autonomic cardiovascular dysregulation in acute schizophrenia.
References
1 Brown S, Inskip H, Barraclough B. Causes of the excess mortality of schizophrenia. Br J Psychiatry2000; 177: 212–217.10.1192/bjp.177.3.212Search in Google Scholar
2 Bär KJ, Letzsch A, Jochum T, Wagner G, Greiner W, Sauer H. Loss of efferent vagal activity in acute schizophrenia. J Psychiatr Res2005; 39: 519–527.10.1016/j.jpsychires.2004.12.007Search in Google Scholar
3 Kuusela TA, Kaila TJ, Kahonen M. Fine structure of the low-frequency spectra of heart rate and blood pressure. BMC Physiol2003; 3: 11.10.1186/1472-6793-3-11Search in Google Scholar
4 Voss A, Kurths J, Kleiner HJ, et al. The application of methods of non-linear dynamics for the improved and predictive recognition of patients threatened by sudden cardiac death. Cardiovasc Res1996; 31: 419–433.10.1016/S0008-6363(96)00008-9Search in Google Scholar
5 Andreasen NC, Arndt S, Miller D, Flaum M, Nopoulos P. Correlational studies of the scale for the assessment of negative symptoms and the scale for the assessment of positive symptoms: an overview and update. Psychopathology1995; 28: 7–17.10.1159/000284894Search in Google Scholar
6 Penaz J, Voigt A, Teichmann W. Contribution to the continuous indirect blood pressure measurement. Z Gesamte Inn Med1976; 31: 1030–1033.Search in Google Scholar
7 Li M, Vitnyi P. An introduction to Kolmogorov complexity and its applications. Heidelberg: Springer Verlag 1979.Search in Google Scholar
8 Lempel A, Ziv A. Universal algorithm for sequential data-compression. IEEE Trans Inf Theory1979; 20: 337–343.Search in Google Scholar
9 Baumert M, Baier V, Haueisen J, et al. Forecasting of life threatening arrhythmias using the compression entropy of heart rate. Methods Inf Med2004; 43: 202–206.10.1055/s-0038-1633859Search in Google Scholar
10 Kubicek WG, Karnegis JN, Patterson RP, Witsoe DA, Mattson RH. Development and evaluation of an impedance cardiac output system. Aerosp Med1966; 37: 1208–1212.Search in Google Scholar
11 Toichi M, Kubota Y, Murai T, et al. The influence of psychotic states on the autonomic nervous system in schizophrenia. Int J Psychophysiol1999; 31: 147–154.10.1016/S0167-8760(98)00047-6Search in Google Scholar
12 Appleby L, Thomas S, Ferrier N, Lewis G, Shaw J, Amos T. Sudden unexplained death in psychiatric in-patients. Br J Psychiatry2000; 176: 405–406.10.1192/bjp.176.5.405Search in Google Scholar
13 Procyshyn RM, Patel K, Thompson DL. Smoking, anticholinergics and schizophrenia. Schizophr Res2004; 67: 313–314.10.1016/S0920-9964(02)00501-7Search in Google Scholar
14 Routledge HC, Chowdhary S, Townend JN. Heart rate variability – a therapeutic target? J Clin Pharm Ther2002; 27: 85–92.10.1046/j.1365-2710.2002.00404.xSearch in Google Scholar PubMed
15 Williams LM, Das P, Harris AW, et al. Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. Am J Psychiatry2004; 161: 480–489.10.1176/appi.ajp.161.3.480Search in Google Scholar PubMed
©2006 by Walter de Gruyter Berlin New York
Articles in the same Issue
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- Influence of sympathetic vascular regulation on heart-rate scaling structure: spinal cord lesion as a model of progressively impaired autonomic control
- Increase in regularity of fetal heart rate variability with age
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- Mixed predictability and cross-validation to assess non-linear Granger causality in short cardiovascular variability series
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Articles in the same Issue
- ESGCO 2006 Conference and Meeting of the European Study Group on Cardiovascular Oscillations, Jena, Germany, May 15–17, 2006
- Cardiovascular Oscillations: from methods and models to clinical applications
- Circadian and ultradian rhythms in heart rate variability
- Influence of age, body mass index, and blood pressure on the carotid intima-media thickness in normotensive and hypertensive patients
- Multivariate and multidimensional analysis of cardiovascular oscillations in patients with heart failure
- Multivariate and multiorgan analysis of cardiorespiratory variability signals: the CAP sleep case
- Role of the autonomic nervous system in generating non-linear dynamics in short-term heart period variability
- Non-linear dynamic analysis of the cardiac rhythm during transient myocardial ischemia
- Complex autonomic dysfunction in cardiovascular, intensive care, and schizophrenic patients assessed by autonomic information flow
- Low HRV entropy is strongly associated with myocardial infarction
- Revisiting the potential of time-domain indexes in short-term HRV analysis
- Fractal dimension in health and heart failure
- Spatiotemporal correlation analyses: a new procedure for standardisation of DC magnetocardiograms
- Changes in heart rate variability of athletes during a training camp
- The missing link between cardiovascular rhythm control and myocardial cell modeling
- Model of the sino-atrial and atrio-ventricular nodes of the conduction system of the human heart
- Modelling long-term heart rate variability: an ARFIMA approach
- Clinical correlates of non-linear indices of heart rate variability in chronic heart failure patients
- Recurrence analysis of nocturnal heart rate in sleep apnea patients
- Normalized correlation dimension for heart rate variability analysis
- Complexity of heart rate fluctuations in near-term sheep and human fetuses during sleep
- Differences between heart rate and blood pressure variability in schizophrenia
- Influence of sympathetic vascular regulation on heart-rate scaling structure: spinal cord lesion as a model of progressively impaired autonomic control
- Increase in regularity of fetal heart rate variability with age
- Fetal heart rate variability in growth restricted fetuses
- Frequency modulation between low- and high-frequency components of the heart rate variability spectrum
- Mixed predictability and cross-validation to assess non-linear Granger causality in short cardiovascular variability series
- Assessment of spatial organization in the atria during paroxysmal atrial fibrillation and adrenergic stimulation
- Attenuated autonomic function in multiple organ dysfunction syndrome across three age groups
- Central vasopressin V1a and V1b receptors modulate the cardiovascular response to air-jet stress in conscious rats
- Heart rate asymmetry by Poincaré plots of RR intervals
- Analyses of cardiovascular oscillations for enhanced diagnosis and risk stratification in cardiac diseases and disorders