Clinical correlates of non-linear indices of heart rate variability in chronic heart failure patients
-
Roberto Maestri
Abstract
We assessed the clinical correlates of a comprehensive set of non-linear heart rate variability (HRV) indices computed from 24-h Holter recordings for 200 stable chronic heart failure (CHF) patients [median age (lower quartile, upper quartile) 54 (47, 58) years, LVEF 23% (19%, 28%)]. A total of 19 non-linear indices belonging to six major families, namely symbolic dynamics, entropy, empirical mode decomposition, fractality-multifractality, unpredictability and Poincaré plots, were considered. Most indices showed a significant association with ejection fraction and with the severity of symptoms, while only two (one each from the fractality and Poincaré plot families) showed an association with aetiology. Only one symbolic dynamics variable was associated with the presence of non-sustained ventricular tachycardia and two symbolic dynamics variables were associated with the rate of ventricular ectopic events. Our results demonstrate the existence of selective links between non-linear indexes of HRV and the clinical status and functional impairment of CHF patients. This indicates that further studies should be designed to investigate the physiopathological mechanisms involved in such links.
References
1 Accardo A, Affinito M, Carrozzi M, Bouquet F. Use of the fractal dimension for the analysis of electroencephalographic time series. Biol Cybern1997; 77: 339–350.10.1007/s004220050394Suche in Google Scholar
2 Allegrini P, Grigolini P, Hamilton P, Palatella L, Raffaelli G. Memory beyond memory in heart beating, a sign of a healthy physiological condition. Phys Rev E2002; 65: 041926.10.1103/PhysRevE.65.041926Suche in Google Scholar
3 Balocchi R, Menicucci D, Santarcangelo E, et al. Deriving the respiratory sinus arrhythmia from the heartbeat time series using empirical mode decomposition. Chaos Solitons Fractals2004; 20: 171–177.10.1016/S0960-0779(03)00441-7Suche in Google Scholar
4 Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B1995; 57: 289–300.10.1111/j.2517-6161.1995.tb02031.xSuche in Google Scholar
5 D'Addio G, Pinna GD, La Rovere MT, Maestri R, Furgi G, Rengo F. Prognostic value of Poincaré plot indexes in chronic heart failure patients. Comput Cardiol2001; 28: 57–60.Suche in Google Scholar
6 Ferrario M, Signorini MG, Cerutti S. Complexity analysis of 24 hours heart rate variability time series. Proceedings of the EMBC 2004 Conference, Vol 2. Pisacataway: IEEE Press 2004: 3956–3959.Suche in Google Scholar
7 Guzzetti S, Borroni E, Garbelli PE, et al. Symbolic dynamics of heart rate variability: a probe to investigate cardiac autonomic modulation. Circulation2005; 112: 465–470.10.1161/CIRCULATIONAHA.104.518449Suche in Google Scholar PubMed
8 Ivanov PC, Amaral LA, Goldberger AL, et al. Multifractality in human heartbeat dynamics. Nature1999; 399: 461–465.10.1038/20924Suche in Google Scholar PubMed
9 Peng CK, Havlin S, Stanley HE, Goldberger AL. Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series. Chaos1995; 5: 82–87.10.1063/1.166141Suche in Google Scholar PubMed
10 Porta A, Baselli G, Guzzetti S, Pagani M, Malliani A, Cerutti S. Prediction of short cardiovascular variability signals based on conditional distribution. IEEE Trans Biomed Eng2000; 47: 1555–1564.10.1109/10.887936Suche in Google Scholar PubMed
11 Richman JS, Moorman JR. Physiological time-series analysis using approximate entropy and sample entropy. Am J Physiol Heart Circ Physiol2000; 278: H2039–2049.10.1152/ajpheart.2000.278.6.H2039Suche in Google Scholar PubMed
12 Wessel N, Ziehmann C, Kurths J, Meyerfeldt U, Schirdewan A, Voss A. Short-term forecasting of life-threatening cardiac arrhythmias based on symbolic dynamics and finite-time growth rates. Phys Rev E2000; 61: 733–739.10.1103/PhysRevE.61.733Suche in Google Scholar
13 Yang AC, Hseu SS, Yien HW, Goldberger AL, Peng CK. Linguistic analysis of the human heartbeat using frequency and rank order statistics. Phys Rev Lett2003; 90: 108103.10.1103/PhysRevLett.90.108103Suche in Google Scholar PubMed
©2006 by Walter de Gruyter Berlin New York
Artikel in diesem Heft
- ESGCO 2006 Conference and Meeting of the European Study Group on Cardiovascular Oscillations, Jena, Germany, May 15–17, 2006
- Cardiovascular Oscillations: from methods and models to clinical applications
- Circadian and ultradian rhythms in heart rate variability
- Influence of age, body mass index, and blood pressure on the carotid intima-media thickness in normotensive and hypertensive patients
- Multivariate and multidimensional analysis of cardiovascular oscillations in patients with heart failure
- Multivariate and multiorgan analysis of cardiorespiratory variability signals: the CAP sleep case
- Role of the autonomic nervous system in generating non-linear dynamics in short-term heart period variability
- Non-linear dynamic analysis of the cardiac rhythm during transient myocardial ischemia
- Complex autonomic dysfunction in cardiovascular, intensive care, and schizophrenic patients assessed by autonomic information flow
- Low HRV entropy is strongly associated with myocardial infarction
- Revisiting the potential of time-domain indexes in short-term HRV analysis
- Fractal dimension in health and heart failure
- Spatiotemporal correlation analyses: a new procedure for standardisation of DC magnetocardiograms
- Changes in heart rate variability of athletes during a training camp
- The missing link between cardiovascular rhythm control and myocardial cell modeling
- Model of the sino-atrial and atrio-ventricular nodes of the conduction system of the human heart
- Modelling long-term heart rate variability: an ARFIMA approach
- Clinical correlates of non-linear indices of heart rate variability in chronic heart failure patients
- Recurrence analysis of nocturnal heart rate in sleep apnea patients
- Normalized correlation dimension for heart rate variability analysis
- Complexity of heart rate fluctuations in near-term sheep and human fetuses during sleep
- Differences between heart rate and blood pressure variability in schizophrenia
- Influence of sympathetic vascular regulation on heart-rate scaling structure: spinal cord lesion as a model of progressively impaired autonomic control
- Increase in regularity of fetal heart rate variability with age
- Fetal heart rate variability in growth restricted fetuses
- Frequency modulation between low- and high-frequency components of the heart rate variability spectrum
- Mixed predictability and cross-validation to assess non-linear Granger causality in short cardiovascular variability series
- Assessment of spatial organization in the atria during paroxysmal atrial fibrillation and adrenergic stimulation
- Attenuated autonomic function in multiple organ dysfunction syndrome across three age groups
- Central vasopressin V1a and V1b receptors modulate the cardiovascular response to air-jet stress in conscious rats
- Heart rate asymmetry by Poincaré plots of RR intervals
- Analyses of cardiovascular oscillations for enhanced diagnosis and risk stratification in cardiac diseases and disorders
Artikel in diesem Heft
- ESGCO 2006 Conference and Meeting of the European Study Group on Cardiovascular Oscillations, Jena, Germany, May 15–17, 2006
- Cardiovascular Oscillations: from methods and models to clinical applications
- Circadian and ultradian rhythms in heart rate variability
- Influence of age, body mass index, and blood pressure on the carotid intima-media thickness in normotensive and hypertensive patients
- Multivariate and multidimensional analysis of cardiovascular oscillations in patients with heart failure
- Multivariate and multiorgan analysis of cardiorespiratory variability signals: the CAP sleep case
- Role of the autonomic nervous system in generating non-linear dynamics in short-term heart period variability
- Non-linear dynamic analysis of the cardiac rhythm during transient myocardial ischemia
- Complex autonomic dysfunction in cardiovascular, intensive care, and schizophrenic patients assessed by autonomic information flow
- Low HRV entropy is strongly associated with myocardial infarction
- Revisiting the potential of time-domain indexes in short-term HRV analysis
- Fractal dimension in health and heart failure
- Spatiotemporal correlation analyses: a new procedure for standardisation of DC magnetocardiograms
- Changes in heart rate variability of athletes during a training camp
- The missing link between cardiovascular rhythm control and myocardial cell modeling
- Model of the sino-atrial and atrio-ventricular nodes of the conduction system of the human heart
- Modelling long-term heart rate variability: an ARFIMA approach
- Clinical correlates of non-linear indices of heart rate variability in chronic heart failure patients
- Recurrence analysis of nocturnal heart rate in sleep apnea patients
- Normalized correlation dimension for heart rate variability analysis
- Complexity of heart rate fluctuations in near-term sheep and human fetuses during sleep
- Differences between heart rate and blood pressure variability in schizophrenia
- Influence of sympathetic vascular regulation on heart-rate scaling structure: spinal cord lesion as a model of progressively impaired autonomic control
- Increase in regularity of fetal heart rate variability with age
- Fetal heart rate variability in growth restricted fetuses
- Frequency modulation between low- and high-frequency components of the heart rate variability spectrum
- Mixed predictability and cross-validation to assess non-linear Granger causality in short cardiovascular variability series
- Assessment of spatial organization in the atria during paroxysmal atrial fibrillation and adrenergic stimulation
- Attenuated autonomic function in multiple organ dysfunction syndrome across three age groups
- Central vasopressin V1a and V1b receptors modulate the cardiovascular response to air-jet stress in conscious rats
- Heart rate asymmetry by Poincaré plots of RR intervals
- Analyses of cardiovascular oscillations for enhanced diagnosis and risk stratification in cardiac diseases and disorders
