Helicobacter pylori-induced downregulation of the secretory leukocyte protease inhibitor (SLPI) in gastric epithelial cell lines and its functional relevance for H. pylori-mediated diseases

References

Abe, T., Kobayashi, N., Yoshimura, K., Trapnell, B.C., Kim, H., Hubbard, R.C., Brewer, M.T., Thompson, R.C., and Crystal R.G. (1991). Expression of the secretory leukoprotease inhibitor gene in epithelial cells. J. Clin. Invest.87, 2207–2215.10.1172/JCI115255Suche in Google Scholar

Alkemade, J.A., Molhuizen, H.O., Ponec, M., Kempenaar, J.A., Zeeuwen, P.L., de Jongh, G.J., van Vlijmen-Willems, I.M., van Erp, P.E., Van de Kerkhof, P.C., and Schalkwijk, J. (1994). SKALP/elafin is an inducible proteinase inhibitor in human epidermal keratinocytes. J. Cell Sci.107, 2335–2342.10.1242/jcs.107.8.2335Suche in Google Scholar

Ashcroft, G.S., Lei, K., Jin, W., Longenecker, G., Kulkarni, A.B., and Greenwell-Wild, T. (2000). Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat. Med.6, 1147–1153.10.1038/80489Suche in Google Scholar

Bergenfeldt, M., Nystrom, M., Bohe, M., Lindstrom, C., Polling, A., and Ohlsson, K. (1996). Localization of immunoreactive secretory leukocyte protease inhibitor (SLPI) in intestinal mucosa. J. Gastroenterol.31, 18–23.10.1007/BF01211182Suche in Google Scholar

Boudier, C., Cadene, M., and Bieth, J.G. (1999). Inhibition of neutrophil cathepsin G by oxidized mucus proteinase inhibitor. Effect of heparin. Biochemistry38, 8451–8457.Suche in Google Scholar

Brandt, S., Kwok, T., Hartig, R., Konig, W., and Backert, S. (2005). NF-κB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc. Natl. Acad. Sci. USA102, 9300–9305.10.1073/pnas.0409873102Suche in Google Scholar

Buhling, F., Peitz, U., Kruger, S., Kuster, D., Vieth, M., Gebert, I., Roessner, A., Weber, E., Malfertheiner, P., and Wex, T. (2004). Cathepsins K, L, B, X and W are differentially expressed in normal and chronically inflamed gastric mucosa. Biol. Chem.385, 439–445.10.1515/BC.2004.051Suche in Google Scholar

Chattopadhyay, A., Gray, L.R., Patton, L.L., Caplan, D.J., Slade, G.D., Tien, H.C., and Shugars, D.C. (2004). Salivary secretory leukocyte protease inhibitor and oral candidiasis in human immunodeficiency virus type 1-infected persons. Infect. Immun.72, 1956–1963.10.1128/IAI.72.4.1956-1963.2004Suche in Google Scholar

Crabtree, J.E. (1996). Immune and inflammatory responses to Helicobacter pylori infection. Scand. J. Gastroenterol. (Suppl.) 215, 3–10.10.3109/00365529609094526Suche in Google Scholar

Dixon, M.F., Genta, R.M., Yardley, J.H., and Correa, P. (1996). Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am. J. Surg. Pathol.20, 1161–1181.10.1097/00000478-199610000-00001Suche in Google Scholar

Dohchin, A., Suzuki, J.I., Seki, H., Masutani, M., Shiroto, H., and Kawakami Y. (2000). Immunostained cathepsins B and L correlate with depth of invasion and different metastatic pathways in early stage gastric carcinoma. Cancer89, 482–487.10.1002/1097-0142(20000801)89:3<482::AID-CNCR2>3.0.CO;2-5Suche in Google Scholar

Duits, L.A., Tjabringa, G.S., Aarts, N.J., van't Wout, J.W., Hiemstra, P.S., Nibbering, P.H., and van Dissel, J.T. (2003). Plasma secretory leukocyte protease inhibitor in febrile patients. Clin. Microbiol. Infect.9, 605–613.10.1046/j.1469-0691.2003.00582.xSuche in Google Scholar

Figueiredo, C., Machado, J.C., and Yamaoka, Y. (2005). Pathogenesis of Helicobacter pylori infection. Helicobacter10 (Suppl. 1), 14–20.10.1111/j.1523-5378.2005.00339.xSuche in Google Scholar

Fink, E., Nettelbeck, R., and Fritz, H. (1986). Inhibition of mast cell chymase by eglin c and antileukoprotease (HUSI-I). Indications for potential biological functions of these inhibitors. Biol. Chem. Hoppe-Seyler367, 567–571.Suche in Google Scholar

Fritz, H. (1988). Human mucus proteinase inhibitor (human MPI). Human seminal inhibitor I (HUSI-I), antileukoprotease (ALP), secretory leukocyte protease inhibitor (SLPI). Biol. Chem. Hoppe-Seyler369, 79–82.Suche in Google Scholar

Gils, A. and Declerck, P.J. (1998). Structure-function relationships in serpins: current concepts and controversies. Thromb. Haemost.80, 531–541.Suche in Google Scholar

Grobmyer, S.R., Barie, P.S., Nathan, C.F., Fuortes, M., Lin, E., Lowry, S.F., Wright, C.D., Weyant, M.J., Hydo, L., Reeves, F., Shiloh, M.U., and Ding, A. (2000). Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia. Crit. Care Med.28, 1276–1282.10.1097/00003246-200005000-00003Suche in Google Scholar

Heinzel, R., Appelhans, H., Gassen, G., Seemuller, U., Machleidt, W., Fritz, H., and Steffens, G. (1986). Molecular cloning and expression of cDNA for human antileukoprotease from cervix uterus. Eur. J. Biochem.160, 61–67.10.1111/j.1432-1033.1986.tb09940.xSuche in Google Scholar

Henriksen, P.A., Hitt, M., Xing, Z., Wang, J., Haslett, C., Riemersma, R.A., Webb, D.J., Kotelevtsev, Y.V., and Sallenave, J.M. (2004). Adenoviral gene delivery of elafin and secretory leukocyte protease inhibitor attenuates NF-κB-dependent inflammatory responses of human endothelial cells and macrophages to atherogenic stimuli. J. Immunol.172, 4535–4544.10.4049/jimmunol.172.7.4535Suche in Google Scholar

Hiemstra, P.S., Maassen, R.J., Stolk, J., Heinzel-Wieland, R., Steffens, G.J., and Dijkman, J.H. (1996). Antibacterial activity of antileukoprotease. Infect. Immun.64, 4520–4524.10.1128/iai.64.11.4520-4524.1996Suche in Google Scholar

Hritz, I., Kuester, D., Vieth, M., Herszenyi, L., Stolte, M., Roessner, A., Tulassay, Z., Wex, T., and Malfertheiner, P. (2006). Secretory leukocyte protease inhibitor expression in various types of gastritis: a specific role of Helicobacter pylori infection. Eur. J. Gastroenterol. Hepatol.18, 277–282.10.1097/00042737-200603000-00008Suche in Google Scholar

Itoh, T., Wakatsuki, Y., Yoshida, M., Usui, T., Matsunaga, Y., Kaneko, S., Chiba, T., and Kita, T. (1999). The vast majority of gastric T cells are polarized to produce T helper 1 type cytokines upon antigenic stimulation despite the absence of Helicobacter pylori infection. J. Gastroenterol.34, 560–570.10.1007/s005350050373Suche in Google Scholar

Jones, B.D. (2005). Salmonella invasion gene regulation: a story of environmental awareness. J. Microbiol.43, 110–117.Suche in Google Scholar

Koyama, S. (2004). Significance of cell-surface expression of matrix metalloproteinases and their inhibitors on gastric epithelium and infiltrating mucosal lymphocytes in progression of Helicobacter pylori-associated gastritis. Scand. J. Gastroenterol.39, 1046–1053.10.1080/00365520410003245Suche in Google Scholar

Lentsch, A.B., Jordan, J.A., Czermak, B.J., Diehl, K.M., Younkin, E.M., Sarma, V., and Ward, P.A. (1999). Inhibition of NF-κB activation and augmentation of IκBβ by secretory leukocyte protease inhibitor during lung inflammation. Am. J. Pathol.154, 239–247.10.1016/S0002-9440(10)65270-4Suche in Google Scholar

Lindholm, C., Quiding-Jarbrink, M., Lonroth, H., and Svennerholm, A.M. (2001). Induction of chemokine and cytokine responses by Helicobacter pylori in human stomach explants. Scand. J. Gastroenterol.36, 1022–1029.Suche in Google Scholar

Naumann, M. (2001). Host cell signaling in Helicobacter pylori infection. Int. J. Med. Microbiol.291, 299–305.10.1078/1438-4221-00133Suche in Google Scholar

Parsonnet, J., Friedman, G.D., Vandersteen, D.P., Chang, Y., Vogelman, J.H., Orentreich, N., and Sibley, R.K. (1991). Helicobacter pylori infection and the risk of gastric carcinoma. N. Engl. J. Med.325, 1127–1131.10.1056/NEJM199110173251603Suche in Google Scholar

Potempa, J., Korzus, E., and Travis, J. (1994). The serpin superfamily of proteinase inhibitors: structure, function, and regulation. J. Biol. Chem.269, 15957–15960.10.1016/S0021-9258(17)33954-6Suche in Google Scholar

Quiding-Jarbrink, M., Lundin, B.S., Lonroth, H., and Svennerholm, A.M. (2001). CD4⁺ and CD8⁺ T cell responses in Helicobacter pylori-infected individuals. Clin. Exp. Immunol.123, 81–87.10.1046/j.1365-2249.2001.01427.xSuche in Google Scholar

Sallenave, J.M. (2000). The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease. Respir. Res.1, 87–92.10.1186/rr18Suche in Google Scholar

Singh, P.K., Tack, B.F., McCray, P.B. Jr., and Welsh, M.J. (2000) Synergistic and additive killing by antimicrobial factors found in human airway surface liquid. Am. J. Physiol. Lung Cell. Mol. Physiol.279, 799–805.10.1152/ajplung.2000.279.5.L799Suche in Google Scholar

Si-Tahar, M., Merlin, D., Sitaraman, S., and Madara, J.L. (2000). Constitutive and regulated secretion of secretory leukocyte proteinase inhibitor by human intestinal epithelial cells. Gastroenterology118, 1061–1071.10.1016/S0016-5085(00)70359-3Suche in Google Scholar

Song, X., Zeng, L., Jin, W., Thompson, J., Mizel, D.E., Lei, K., Billinghurst, R.C., Poole, A.R., and Wahl, S.M. (1999). Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritis. J. Exp. Med.190, 535–542.10.1084/jem.190.4.535Suche in Google Scholar PubMed PubMed Central

Suerbaum, S. and Michetti, P. (2002). Helicobacter pylori infection. N. Engl. J. Med.347, 1175–1186.10.1056/NEJMra020542Suche in Google Scholar PubMed

Taggart, C.C., Lowe, G.J., Greene, C.M., Mulgrew, A.T., O'Neill, S.J., Levine, R.L., and McElvaney, N.G. (2000). Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor. J. Biol. Chem.276, 33345–33352.Suche in Google Scholar

Taggart, C.C., Greene, C.M., McElvaney, N.G., and O'Neill, S. (2002). Secretory leucoprotease inhibitor prevents LPS-induced IκBβ degradation without affecting phosphorylation or ubiquitination. J. Biol. Chem.277, 33648–33653.10.1074/jbc.M203710200Suche in Google Scholar PubMed

Tam, E.M., Morrison, C.J., Wu, Y.I., Stack, M.S., and Overall, C.M. (2004). Membrane protease proteomics: isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates. Proc. Natl. Acad. Sci. USA101, 6917–6922.10.1073/pnas.0305862101Suche in Google Scholar PubMed PubMed Central

Thompson, R.C. and Ohlsson, K. (1986). Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase. Proc. Natl. Acad. Sci. USA83, 6692–6696.10.1073/pnas.83.18.6692Suche in Google Scholar PubMed PubMed Central

Toh, B.H., van Driel, I.R., and Gleeson, P.A. (1997). Pernicious anemia. N. Engl. J. Med.337, 1441–1448.10.1056/NEJM199711133372007Suche in Google Scholar PubMed

Uemura, N., Okamoto, S., Yamamoto, S., Matsumura, N., Yamaguchi, S., Yamakido, M., Taniyama, K., Sasaki, N., and Schlemper, R.J. (2001). Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med.345, 784–789.10.1056/NEJMoa001999Suche in Google Scholar PubMed

Wang, X., Li, X., Xu, L., Zhan, Y., Yaish-Ohad, S., Erhardt, J.A., Barone, F.C., and Feuerstein, G.Z. (2003). Up-regulation of secretory leukocyte protease inhibitor (SLPI) in the brain after ischemic stroke: adenoviral expression of SLPI protects brain from ischemic injury. Mol. Pharmacol.64, 833–840.10.1124/mol.64.4.833Suche in Google Scholar PubMed

Wex, T., Treiber, G., Lendeckel, U., and Malfertheiner, P. (2003). A two step method for the extraction of high-quality RNA from endoscopic biopsies. Clin. Chem. Lab. Med.41, 1033–1037.10.1515/CCLM.2003.159Suche in Google Scholar PubMed

Wex, T., Treiber, G., Nilius, M., Vieth, M., Roessner, A., and Malfertheiner, P. (2004a). Helicobacter pylori-mediated gastritis induces local downregulation of secretory leukocyte protease inhibitor in the antrum. Infect. Immun.72, 2383–2385.10.1128/IAI.72.4.2383-2385.2004Suche in Google Scholar PubMed PubMed Central

Wex, T., Sokic-Milutinovic, A., Todorovic, V., Bjelovic, M., Milosavljevic, T., Pesko, P., and Malfertheiner, P. (2004b). Down-regulation of secretory leukocyte protease inhibitor expression in gastric mucosa is a general phenomenon in Helicobacter pylori-related gastroduodenal diseases. Dig. Dis.22, 390–395.10.1159/000083604Suche in Google Scholar PubMed

Wex, T., Zack, M., and Malfertheiner, P. (2006a). Proteases in Helicobacter pylori-mediated diseases. In: Proteases in Biology and Disease, Volume 5: Proteases in Gastrointestinal Tissues, U. Lendeckel and N.M. Hooper, eds. (New York, USA: Springer Science/Business Media Inc.), pp. 61–87.10.1007/1-4020-4483-6_3Suche in Google Scholar

Wex, T., Ye, S., Treiber, G., Vieth, M., Roessner, A., and Malfertheiner, P. (2006b). H. pylori infection, but not low-dose aspirin, results in a local reduction of the secretory leukocyte protease inhibitor (SLPI) in gastroduodenal mucosa. Helicobacter11, 31–38.10.1111/j.0083-8703.2006.00376.xSuche in Google Scholar PubMed

Wiedow, O. and Meyer-Hoffert, U. (2005). Neutrophil serine proteases: potential key regulators of cell signaling during inflammation. J. Intern. Med.257, 319–328.10.1111/j.1365-2796.2005.01476.xSuche in Google Scholar

Yang, J., Zhu, J., Sun, D., and Ding, A. (2005). Suppression of macrophage responses to bacterial lipopolysaccharide (LPS) by secretory leukocyte protease inhibitor (SLPI) is independent of its anti-protease function. Biochim. Biophys. Acta1745, 310–317.10.1016/j.bbamcr.2005.07.006Suche in Google Scholar

Zhang, D., Simmen, R.C., Michel, F.J., Zhao, G., Vale-Cruz, D., and Simmen, F.A. (2002). Secretory leukocyte protease inhibitor mediates proliferation of human endometrial epithelial cells by positive and negative regulation of growth-associated genes. J. Biol. Chem.277, 29999–30009.10.1074/jbc.M203503200Suche in Google Scholar

Zarrilli, R., Ricci, V., and Romano, M. (1999). Molecular response of gastric epithelial cells to Helicobacter pylori-induced cell damage. Cell Microbiol.1, 93–99.10.1046/j.1462-5822.1999.00018.xSuche in Google Scholar

Zhu, J., Nathan, C., Jin, W., Sim, D., Ashcroft, G.S., Wahl, S.M., Lacomis, L., Erdjument-Bromage, H., Tempst, P., Wright, C.D., and Ding, A. (2002). Conversion of proepithelin to epithelia: roles of SLPI and elastase in host defense and wound repair. Cell111, 867–878.10.1016/S0092-8674(02)01141-8Suche in Google Scholar