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PREPL: a putative novel oligopeptidase propelled into the limelight

  • Kevin Martens , Rita Derua , Sandra Meulemans , Etienne Waelkens , Jaak Jaeken , Gert Matthijs and John W.M. Creemers
Published/Copyright: July 20, 2006
Biological Chemistry
From the journal Volume 387 Issue 7

Abstract

The prolyl endopeptidase-like protein PREPL has recently attracted attention because its gene is located within two contiguous gene-deletion syndromes, the 2p21 deletion syndrome and the hypotonia-cystinuria syndrome. Deletion of the gene results in hypotonia at birth, failure to thrive and growth hormone deficiency. PREPL is highly reactive against an activity-based probe, which indicates the presence of an intact catalytic machinery. However, no substrate has been found yet. The unique carboxy-terminus of the catalytic domain might contain the key to the as yet elusive specificity.

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Published Online: 2006-07-20
Published in Print: 2006-07-01

©2006 by Walter de Gruyter Berlin New York

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