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Expression of the Tissue Kallikrein-Kinin Cascade in Granulosa Cells of the Ovary

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Veröffentlicht/Copyright: 1. Juni 2005
Biological Chemistry
Aus der Zeitschrift Band 383 Heft 12

Abstract

The serine protease, tissue kininogenase (kallikrein), belongs to a unique family of enzymes that cleaves the decapeptide, kallidin, from the endogenous substrate kininogen. By analysis of genealogy patterns rat KLK gene family members have been detected in ovarian luteinizing granulosa cells of both gonadotrophin treated and nontreated control rats. Recently, we demonstrated that tissue kininogenase showed intense immunolabeling in angiogenic endothelial cells isolated from bovine mature and regressing corpora lutea. Therefore, the question to answer was whether granulosa cells associated with ovarian vascularization possess the same capacity to express the kallikreinkinin cascade as do microvascular endothelial cells. As a first step, experiments were designed to determine the expression and visualization of tissue kininogenase (both active and pro forms) as well as kininogen and kinin receptors in granulosa cells of different developmental stages and segments of the ovarian follicle by immunoperoxidase assay, confocal fluorescent microscopy and in situ hybridization.

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Published Online: 2005-06-01
Published in Print: 2002-12-09

Copyright © 2002 by Walter de Gruyter GmbH & Co. KG

Artikel in diesem Heft

  1. Processing and Activation of Lysosomal Proteinases
  2. Evidence That E-Box Promoter Elements and MyoD Transcription Factors Play a Role in the Induction of Cathepsin B Gene Expression during Human Myoblast Differentiation
  3. Transcription Factor Egr-1 Activates Collagen Expression in Immortalized Fibroblasts or Fibrosarcoma Cells
  4. The Receptor-Bound N-Terminal Ectodomain of the Amyloid Precursor Protein Is Associated with Membrane Rafts
  5. Evaluation of Similarities in the cis/trans Isomerase Function of Trigger Factor and DnaK
  6. The Chloroplast Import Receptor Toc34 Functions as Preprotein-Regulated GTPase
  7. cis-4-Methylsphingosine Phosphate Induces Apoptosis in Neuroblastoma Cells by Opposite Effects on p38 and ERK Mitogen-Activated Protein Kinases
  8. Evidence for the Involvement of the Unique C-Tail of S100A9 in the Binding of Arachidonic Acid to the Heterocomplex S100A8/A9
  9. The Primary Structure of Three Hemoglobin Chains from the Indigo Snake (Drymarchon corais erebennus, Serpentes): First Evidence for αD Chains and Two β Chain Types in Snakes
  10. Expression of the Tissue Kallikrein-Kinin Cascade in Granulosa Cells of the Ovary
  11. Chondroitin Sulfate Proteoglycan Is a Potent Enhancer in the Processing of Procathepsin L
  12. Tyrosinase-Mediated Oxidation of Acetaminophen to 4-Acetamido-o- Benzoquinone
  13. Properties of Baculovirus Particles Displaying GFP Analyzed by Fluorescence Correlation Spectroscopy
  14. The Promoter Context Determines Mutual Repression or Synergism between NF-κB and the Glucocorticoid Receptor
  15. Expression of Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI-2) in Human Testis: Identification of a Distinct Transcription Start Site for the HAI-2 Gene in Testis
  16. Identification and Characterization of an IgG Binding Protein in the Secretion of the Rat Coagulating Gland
  17. Characterization of Different Reactive Lysines in Bovine Heart Mitochondrial Porin
  18. Determination of the mRNA Sequence of Cathepsin Y, a Cysteine Endopeptidase from Rat Spleen, and Confirmation of Its Ubiquitous
  19. Acknowledgement
  20. Content Index
  21. Author Index
  22. Subject Index
https://doi.org/10.1515/BC.2002.215

Artikel in diesem Heft

  1. Processing and Activation of Lysosomal Proteinases
  2. Evidence That E-Box Promoter Elements and MyoD Transcription Factors Play a Role in the Induction of Cathepsin B Gene Expression during Human Myoblast Differentiation
  3. Transcription Factor Egr-1 Activates Collagen Expression in Immortalized Fibroblasts or Fibrosarcoma Cells
  4. The Receptor-Bound N-Terminal Ectodomain of the Amyloid Precursor Protein Is Associated with Membrane Rafts
  5. Evaluation of Similarities in the cis/trans Isomerase Function of Trigger Factor and DnaK
  6. The Chloroplast Import Receptor Toc34 Functions as Preprotein-Regulated GTPase
  7. cis-4-Methylsphingosine Phosphate Induces Apoptosis in Neuroblastoma Cells by Opposite Effects on p38 and ERK Mitogen-Activated Protein Kinases
  8. Evidence for the Involvement of the Unique C-Tail of S100A9 in the Binding of Arachidonic Acid to the Heterocomplex S100A8/A9
  9. The Primary Structure of Three Hemoglobin Chains from the Indigo Snake (Drymarchon corais erebennus, Serpentes): First Evidence for αD Chains and Two β Chain Types in Snakes
  10. Expression of the Tissue Kallikrein-Kinin Cascade in Granulosa Cells of the Ovary
  11. Chondroitin Sulfate Proteoglycan Is a Potent Enhancer in the Processing of Procathepsin L
  12. Tyrosinase-Mediated Oxidation of Acetaminophen to 4-Acetamido-o- Benzoquinone
  13. Properties of Baculovirus Particles Displaying GFP Analyzed by Fluorescence Correlation Spectroscopy
  14. The Promoter Context Determines Mutual Repression or Synergism between NF-κB and the Glucocorticoid Receptor
  15. Expression of Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI-2) in Human Testis: Identification of a Distinct Transcription Start Site for the HAI-2 Gene in Testis
  16. Identification and Characterization of an IgG Binding Protein in the Secretion of the Rat Coagulating Gland
  17. Characterization of Different Reactive Lysines in Bovine Heart Mitochondrial Porin
  18. Determination of the mRNA Sequence of Cathepsin Y, a Cysteine Endopeptidase from Rat Spleen, and Confirmation of Its Ubiquitous
  19. Acknowledgement
  20. Content Index
  21. Author Index
  22. Subject Index
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