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Msb4p, a Protein Involved in Cdc42p-Dependent Organization of the Actin Cytoskeleton, Is a Ypt/Rab-Specific GAP

  • S. Albert and D. Gallwitz
Published/Copyright: July 5, 2005
Biological Chemistry
From the journal Volume 381 Issue 5-6

Abstract

Ypt/Rab proteins of the Ras superfamily are regulators of protein transport in exo- and endocytosis. Like Ras and Rho proteins, they have a slow intrinsic GTPase activity that can be accelerated by several orders of magnitude by GTPase-activating proteins (GAP). Here we describe a new member of a family of Ypt/Rab-specific GAPs, Msb4p/Gyp4p, that shares with other Gyp family members significant homology in the catalytic domain, recently identified in Gyp1p and Gyp7p. Purified Msb4p/Gyp4p acts primarily on Sec4p, Ypt6p and Ypt7p and might have a role in polarized secretion.

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Published Online: 2005-07-05
Published in Print: 2000-06-21

Copyright © 2000 by Walter de Gruyter GmbH & Co. KG

Articles in the same Issue

  1. Highlight: GTP Binding Proteins Central Regulators in Cell Biology
  2. Signal Transduction and Post-Transcriptional Gene Expression
  3. Regulation of GTPases in the Bacterial Translation Machinery
  4. GTPase Mechanisms and Functions of Translation Factors on the Ribosome
  5. The Role of Heterotrimeric G Proteins in Platelet Activation
  6. Upstream and Downstream of Ran GTPase
  7. Nogo-A, a Potent Inhibitor of Neurite Outgrowth and Regeneration
  8. Rho GTPases as Targets of Bacterial Protein Toxins
  9. A Conserved Gβ Binding (GBB) Sequence Motif in Ste20p/PAK Family Protein Kinases
  10. Identification of a CpG Island in the Human LRP-2 Gene and Analysis of Its Methylation Status in Parathyroid Adenomas
  11. Theoretical Description of the Direct Exponential Amplification and Sequencing (DEXAS) Method
  12. Adenine Nucleotide N-Glycosidase Activity of the A-Chain of Cinnamomin Characterized by 1H-Nuclear Magnetic Resonance
  13. Msb4p, a Protein Involved in Cdc42p-Dependent Organization of the Actin Cytoskeleton, Is a Ypt/Rab-Specific GAP
  14. Muscle Phosphorylase Kinase Is Not a Substrate of AMP-Activated Protein Kinase
  15. Cationic Lipopolyamines Induce Degradation of PrPSc in Scrapie-Infected Mouse Neuroblastoma Cells
  16. Glycosylphosphatidylinositol-Specific Phospholipase D of Human Serum Activity Modulation by Naturally Occurring Amphiphiles
  17. Retrieval of the mrp2 Gene Encoded Conjugate Export Pump from the Canalicular Membrane Contributes to Cholestasis Induced by tert-Butyl Hydroperoxide and Chloro-Dinitrobenzene
  18. Matrix Metalloproteinases-2, -3, -7, -9 and -10, But Not MMP-11, Are Differentially Expressed in Normal, Benign Tumorigenic and Malignant Human Keratinocyte Cell Lines
  19. Human Keratinocyte Cell Lines Differ in the Expression of the Collagenolytic Matrix Metallo-proteinases-1, -8, and -13 and of TIMP-1
  20. Inducibility of the Streptomyces traRts107-Ptra Expression Cassette in Mycobacterium smegmatis
  21. Shortest Known Prion Protein Allele in Highly BSE-Susceptible Lemurs
  22. Prostaglandin Deficiency Promotes Sensitization of Adenylyl Cyclase
https://doi.org/10.1515/BC.2000.059

Articles in the same Issue

  1. Highlight: GTP Binding Proteins Central Regulators in Cell Biology
  2. Signal Transduction and Post-Transcriptional Gene Expression
  3. Regulation of GTPases in the Bacterial Translation Machinery
  4. GTPase Mechanisms and Functions of Translation Factors on the Ribosome
  5. The Role of Heterotrimeric G Proteins in Platelet Activation
  6. Upstream and Downstream of Ran GTPase
  7. Nogo-A, a Potent Inhibitor of Neurite Outgrowth and Regeneration
  8. Rho GTPases as Targets of Bacterial Protein Toxins
  9. A Conserved Gβ Binding (GBB) Sequence Motif in Ste20p/PAK Family Protein Kinases
  10. Identification of a CpG Island in the Human LRP-2 Gene and Analysis of Its Methylation Status in Parathyroid Adenomas
  11. Theoretical Description of the Direct Exponential Amplification and Sequencing (DEXAS) Method
  12. Adenine Nucleotide N-Glycosidase Activity of the A-Chain of Cinnamomin Characterized by 1H-Nuclear Magnetic Resonance
  13. Msb4p, a Protein Involved in Cdc42p-Dependent Organization of the Actin Cytoskeleton, Is a Ypt/Rab-Specific GAP
  14. Muscle Phosphorylase Kinase Is Not a Substrate of AMP-Activated Protein Kinase
  15. Cationic Lipopolyamines Induce Degradation of PrPSc in Scrapie-Infected Mouse Neuroblastoma Cells
  16. Glycosylphosphatidylinositol-Specific Phospholipase D of Human Serum Activity Modulation by Naturally Occurring Amphiphiles
  17. Retrieval of the mrp2 Gene Encoded Conjugate Export Pump from the Canalicular Membrane Contributes to Cholestasis Induced by tert-Butyl Hydroperoxide and Chloro-Dinitrobenzene
  18. Matrix Metalloproteinases-2, -3, -7, -9 and -10, But Not MMP-11, Are Differentially Expressed in Normal, Benign Tumorigenic and Malignant Human Keratinocyte Cell Lines
  19. Human Keratinocyte Cell Lines Differ in the Expression of the Collagenolytic Matrix Metallo-proteinases-1, -8, and -13 and of TIMP-1
  20. Inducibility of the Streptomyces traRts107-Ptra Expression Cassette in Mycobacterium smegmatis
  21. Shortest Known Prion Protein Allele in Highly BSE-Susceptible Lemurs
  22. Prostaglandin Deficiency Promotes Sensitization of Adenylyl Cyclase
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