Chapter 3 Harnessing micro/nanoemulsion for transnasal drug delivery with enhanced efficacy and precision
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Shweta Ramkar
Abstract
Transnasaltransnasal drug delivery has been a subject of significant interest as a useful and efficient pathway for the delivery of therapeutic drugs. This chapter discusses the possibilities of transnasal delivery systems, highlighting the use of micro- and nano-emulsions in improved drug absorption and bioavailability. The nasal pathway has several important benefits such as quick onset of action, circumvention of first-pass metabolism, simplicity of administration, and possibility of both systemic and local action. Micro-/nano-emulsions, due to their minute particle size, thermodynamic stability, and capability for encapsulation of both hydrophilic and lipophilic drugs, are being used as great carriers for any number of different pharmaceutical substances. Their preparation enhances solubilization, stabilization, and muco-permeabilitypermeability, with room for controlled as well as target-specific delivery. Anatomy and physiology of the nasal cavitynasal cavity, absorption mechanisms of drug, and challenges to effective delivery are elaborated in the chapter. Strategies to transcend such obstacles, for example, utilization of mucoadhesive agents, permeation enhancers, and inhibitors of enzymes are discussed as well. While the chapter points toward the promise of direct nosenose-to-brain deliverybrain delivery in neurological diseases, its core discussion goes on to cover wide-ranging therapeutic fields such as pain management, hormone therapy, infections of the nasal cavity, and vaccine delivery. Trends in formulation science, regulatory insights, and directions for the future, for example, personalized medicine and smart delivery systems, are also covered. In general, the chapter highlights the multifaceted uses and future potential of transnasal micro/nanoemulsion systems in contemporary pharmaceutical delivery.
Abstract
Transnasaltransnasal drug delivery has been a subject of significant interest as a useful and efficient pathway for the delivery of therapeutic drugs. This chapter discusses the possibilities of transnasal delivery systems, highlighting the use of micro- and nano-emulsions in improved drug absorption and bioavailability. The nasal pathway has several important benefits such as quick onset of action, circumvention of first-pass metabolism, simplicity of administration, and possibility of both systemic and local action. Micro-/nano-emulsions, due to their minute particle size, thermodynamic stability, and capability for encapsulation of both hydrophilic and lipophilic drugs, are being used as great carriers for any number of different pharmaceutical substances. Their preparation enhances solubilization, stabilization, and muco-permeabilitypermeability, with room for controlled as well as target-specific delivery. Anatomy and physiology of the nasal cavitynasal cavity, absorption mechanisms of drug, and challenges to effective delivery are elaborated in the chapter. Strategies to transcend such obstacles, for example, utilization of mucoadhesive agents, permeation enhancers, and inhibitors of enzymes are discussed as well. While the chapter points toward the promise of direct nosenose-to-brain deliverybrain delivery in neurological diseases, its core discussion goes on to cover wide-ranging therapeutic fields such as pain management, hormone therapy, infections of the nasal cavity, and vaccine delivery. Trends in formulation science, regulatory insights, and directions for the future, for example, personalized medicine and smart delivery systems, are also covered. In general, the chapter highlights the multifaceted uses and future potential of transnasal micro/nanoemulsion systems in contemporary pharmaceutical delivery.
Chapters in this book
- Frontmatter I
- Foreword V
- Foreword VII
- Contents V
- List of contributing authors IX
- Introduction 1
- Chapter 1 Techniques for characterizing micro/nanoemulsions in pharmaceutical formulations 9
- Chapter 2 Micro/nanoemulsions in dermatology for enhanced therapeutic solutions 49
- Chapter 3 Harnessing micro/nanoemulsion for transnasal drug delivery with enhanced efficacy and precision 79
- Chapter 4 Micro/nanoemulsions redefining cosmeceutical formulation for optimal skin health 107
- Chapter 5 Accelerating recovery through advanced wound healing applications of micro/nanoemulsions 127
- Chapter 6 Precision oncology: nanoemulsions as pioneers in the delivery of anticancer agents, immunomodulators, and vaccines 171
- Chapter 7 Cutting-edge innovations: advances and applications of micro/nanoemulsions in gel formulations 211
- Chapter 8 Clinical frontiers and regulatory status of micro/nanoemulsions 251
- Chapter 9 Future prospects of micro/nanoemulsions in enhancing drug performance 269
- Index 289
Chapters in this book
- Frontmatter I
- Foreword V
- Foreword VII
- Contents V
- List of contributing authors IX
- Introduction 1
- Chapter 1 Techniques for characterizing micro/nanoemulsions in pharmaceutical formulations 9
- Chapter 2 Micro/nanoemulsions in dermatology for enhanced therapeutic solutions 49
- Chapter 3 Harnessing micro/nanoemulsion for transnasal drug delivery with enhanced efficacy and precision 79
- Chapter 4 Micro/nanoemulsions redefining cosmeceutical formulation for optimal skin health 107
- Chapter 5 Accelerating recovery through advanced wound healing applications of micro/nanoemulsions 127
- Chapter 6 Precision oncology: nanoemulsions as pioneers in the delivery of anticancer agents, immunomodulators, and vaccines 171
- Chapter 7 Cutting-edge innovations: advances and applications of micro/nanoemulsions in gel formulations 211
- Chapter 8 Clinical frontiers and regulatory status of micro/nanoemulsions 251
- Chapter 9 Future prospects of micro/nanoemulsions in enhancing drug performance 269
- Index 289
