7 Antioxidant and antibacterial activities of two xanthones derivatives isolated from the leaves extract of Anthocleista schweinfurthii Gilg (Loganiaceae)
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Francine Tsopjio Nkouam
Abstract
Phytochemical investigations on the dechlorophyllated extract of Anthocleista schweinfurthii Gilg (Loganiaceae) leaves have enabled the isolation of two xanthones derivatives: 1,8-dihydroxy-2,6-dimethoxyxanthone (1) and 1-hydroxy- 3,7,8-trimethoxyxanthone (2) known, respectively, as swertiaperenin (1) and decussatin (2), but isolated here for the first time from this plant. The structures of these compounds were investigated by rigorous analysis of their one- and two-dimensional NMR spectral data. Compounds (1) and (2) were evaluated for their antioxidant activities using the 1,1-diphenyl-2-picrylhydrazyl method (DPPH°); the reducing power of iron III (FRAP) and antibacterial activity by the solid diffusion method on three bacteria strains (Escherichia coli, Staphylococcus aureus, and Bacillus cereus). The results obtained show that the two compounds have good antioxidant and antibacterial activities. Obviously, swertiaperenin and decussatin are among the active secondary’s metabolites responsible for the biological activity of A. schweinfurthii Gild recognized by the Cameroonian populations.
Abstract
Phytochemical investigations on the dechlorophyllated extract of Anthocleista schweinfurthii Gilg (Loganiaceae) leaves have enabled the isolation of two xanthones derivatives: 1,8-dihydroxy-2,6-dimethoxyxanthone (1) and 1-hydroxy- 3,7,8-trimethoxyxanthone (2) known, respectively, as swertiaperenin (1) and decussatin (2), but isolated here for the first time from this plant. The structures of these compounds were investigated by rigorous analysis of their one- and two-dimensional NMR spectral data. Compounds (1) and (2) were evaluated for their antioxidant activities using the 1,1-diphenyl-2-picrylhydrazyl method (DPPH°); the reducing power of iron III (FRAP) and antibacterial activity by the solid diffusion method on three bacteria strains (Escherichia coli, Staphylococcus aureus, and Bacillus cereus). The results obtained show that the two compounds have good antioxidant and antibacterial activities. Obviously, swertiaperenin and decussatin are among the active secondary’s metabolites responsible for the biological activity of A. schweinfurthii Gild recognized by the Cameroonian populations.
Kapitel in diesem Buch
- Frontmatter I
- A virtual conference on chemistry and its applications (VCCA-2021) was organized online from 9th to 13th August 2021 V
- Contents VII
- List of contributing authors XIII
- 1 Performance and kinetics of a fluidized bed anaerobic reactor treating distillery effluent 1
- 2 Sustainability of ameliorative potentials of urea spiked poultry manure biochar types in simulated sodic soils 15
- 3 Effects of alum, soda ash, and carbon dioxide on 40–50 year old concrete wastewater tanks 29
- 4 A review of sludge production in South Africa municipal wastewater treatment plants, analysis of handling cost and potential minimization methods 39
- 5 A comparison of two digestion methods and heavy metals determination in sediments 51
- 6 Simultaneous remediation of polycyclic aromatic hydrocarbon and heavy metals in wastewater with zerovalent iron-titanium oxide nanoparticles (ZVI-TiO2) 71
- 7 Antioxidant and antibacterial activities of two xanthones derivatives isolated from the leaves extract of Anthocleista schweinfurthii Gilg (Loganiaceae) 81
- 8 Use of biochemical markers for diabetes prevention in the new decade 93
- 9 Cytotoxicity test and antibacterial assay on the compound produced by the isolation and modification of artonin E from Artocarpus kemando Miq. 105
- 10 Antibacterial, antioxidant and cytotoxic activities of the stem bark of Archidendron jiringa ( Jack) I.C. Nielsen 123
- 11 Fabaceae: a significant flavonoid source for plant and human health 135
- 12 Developing a questionnaire for diabetes mellitus type 2 risk effects and precondition factors – multivariate statistical paths 147
- 13 Chromatographic characterization of the fusion protein SARS-CoV-2 S protein (RBD)-hFc 161
- Index 173
Kapitel in diesem Buch
- Frontmatter I
- A virtual conference on chemistry and its applications (VCCA-2021) was organized online from 9th to 13th August 2021 V
- Contents VII
- List of contributing authors XIII
- 1 Performance and kinetics of a fluidized bed anaerobic reactor treating distillery effluent 1
- 2 Sustainability of ameliorative potentials of urea spiked poultry manure biochar types in simulated sodic soils 15
- 3 Effects of alum, soda ash, and carbon dioxide on 40–50 year old concrete wastewater tanks 29
- 4 A review of sludge production in South Africa municipal wastewater treatment plants, analysis of handling cost and potential minimization methods 39
- 5 A comparison of two digestion methods and heavy metals determination in sediments 51
- 6 Simultaneous remediation of polycyclic aromatic hydrocarbon and heavy metals in wastewater with zerovalent iron-titanium oxide nanoparticles (ZVI-TiO2) 71
- 7 Antioxidant and antibacterial activities of two xanthones derivatives isolated from the leaves extract of Anthocleista schweinfurthii Gilg (Loganiaceae) 81
- 8 Use of biochemical markers for diabetes prevention in the new decade 93
- 9 Cytotoxicity test and antibacterial assay on the compound produced by the isolation and modification of artonin E from Artocarpus kemando Miq. 105
- 10 Antibacterial, antioxidant and cytotoxic activities of the stem bark of Archidendron jiringa ( Jack) I.C. Nielsen 123
- 11 Fabaceae: a significant flavonoid source for plant and human health 135
- 12 Developing a questionnaire for diabetes mellitus type 2 risk effects and precondition factors – multivariate statistical paths 147
- 13 Chromatographic characterization of the fusion protein SARS-CoV-2 S protein (RBD)-hFc 161
- Index 173
