8 Present trends in the encapsulation of anticancer drugs
-
Xavier Montané
Abstract
Different nanomedicine devices that were developed during the recent years can be suitable candidates for their application in the treatment of various deadly diseases such as cancer. From all the explored devices, the nanoencapsulation of several anticancer medicines is a very promising approach to overcome some drawbacks of traditional medicines: administered dose of the drugs, drug toxicity, low solubility of drugs, uncontrolled drug delivery, resistance offered by the physiological barriers in the body to drugs, among others. In this chapter, the most important and recent progress in the encapsulation of anticancer medicines is examined: methods of preparation of distinct nanoparticles (inorganic nanoparticles, dendrimers, biopolymeric nanoparticles, polymeric micelles, liposomes, polymersomes, carbon nanotubes, quantum dots, and hybrid nanoparticles), drug loading and drug release mechanisms. Furthermore, the possible applications in cancer prevention, diagnosis, and cancer therapy of some of these nanoparticles have been highlighted.
Abstract
Different nanomedicine devices that were developed during the recent years can be suitable candidates for their application in the treatment of various deadly diseases such as cancer. From all the explored devices, the nanoencapsulation of several anticancer medicines is a very promising approach to overcome some drawbacks of traditional medicines: administered dose of the drugs, drug toxicity, low solubility of drugs, uncontrolled drug delivery, resistance offered by the physiological barriers in the body to drugs, among others. In this chapter, the most important and recent progress in the encapsulation of anticancer medicines is examined: methods of preparation of distinct nanoparticles (inorganic nanoparticles, dendrimers, biopolymeric nanoparticles, polymeric micelles, liposomes, polymersomes, carbon nanotubes, quantum dots, and hybrid nanoparticles), drug loading and drug release mechanisms. Furthermore, the possible applications in cancer prevention, diagnosis, and cancer therapy of some of these nanoparticles have been highlighted.
Kapitel in diesem Buch
- Frontmatter I
- Preface V
- Contents VII
- List of contributing authors XIII
- 1 Personalized and targeted therapies 1
- 2 Advancements in cancer chemotherapy 27
- 3 Principles of radiation therapy 51
- 4 Advanced cell culture techniques for cancer research 81
- 5 Natural substances in cancer—do they work? 103
- 6 The application of the natural killer cells, macrophages and dendritic cells in treating various types of cancer 137
- 7 Non-radioactive imaging strategies for in vivo immune cell tracking 173
- 8 Present trends in the encapsulation of anticancer drugs 193
- 9 3D tumor model – a platform for anticancer drug development 213
- Index 241
Kapitel in diesem Buch
- Frontmatter I
- Preface V
- Contents VII
- List of contributing authors XIII
- 1 Personalized and targeted therapies 1
- 2 Advancements in cancer chemotherapy 27
- 3 Principles of radiation therapy 51
- 4 Advanced cell culture techniques for cancer research 81
- 5 Natural substances in cancer—do they work? 103
- 6 The application of the natural killer cells, macrophages and dendritic cells in treating various types of cancer 137
- 7 Non-radioactive imaging strategies for in vivo immune cell tracking 173
- 8 Present trends in the encapsulation of anticancer drugs 193
- 9 3D tumor model – a platform for anticancer drug development 213
- Index 241
