5 Natural substances in cancer—do they work?
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Adrianna Sobolewska
Abstract
Owing to anticancer properties of selected natural substances, it is assumed that they have potential to be used in oncological therapy. Here, the recently proven effects of the selected natural polyphenols, resveratrol and curcumin, are described. Secondly, the potential of probiotics and prebiotics in modulation of immunological response and/or enhancing the chemotherapeutic treatments is reported based on the recent clinical trials. Further, the chapter presents current knowledge regarding the targeted supplementation of the patient with probiotic bacteria and known efficacy of probiotics to support immunotherapy. The major clinical trials are listed, aiming to verify whether, and to which extent the manipulation of patient’s microbiome can improve the outcome of chemotherapies. In the end, a potential of natural substances and feed ingredients to pose epigenetic changes is highlighted. The chapter provides an insight into the scientific proofs about natural bioactive substances in relation to cancer treatment, leaded by the question - do they really work?
Abstract
Owing to anticancer properties of selected natural substances, it is assumed that they have potential to be used in oncological therapy. Here, the recently proven effects of the selected natural polyphenols, resveratrol and curcumin, are described. Secondly, the potential of probiotics and prebiotics in modulation of immunological response and/or enhancing the chemotherapeutic treatments is reported based on the recent clinical trials. Further, the chapter presents current knowledge regarding the targeted supplementation of the patient with probiotic bacteria and known efficacy of probiotics to support immunotherapy. The major clinical trials are listed, aiming to verify whether, and to which extent the manipulation of patient’s microbiome can improve the outcome of chemotherapies. In the end, a potential of natural substances and feed ingredients to pose epigenetic changes is highlighted. The chapter provides an insight into the scientific proofs about natural bioactive substances in relation to cancer treatment, leaded by the question - do they really work?
Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
- List of contributing authors XIII
- 1 Personalized and targeted therapies 1
- 2 Advancements in cancer chemotherapy 27
- 3 Principles of radiation therapy 51
- 4 Advanced cell culture techniques for cancer research 81
- 5 Natural substances in cancer—do they work? 103
- 6 The application of the natural killer cells, macrophages and dendritic cells in treating various types of cancer 137
- 7 Non-radioactive imaging strategies for in vivo immune cell tracking 173
- 8 Present trends in the encapsulation of anticancer drugs 193
- 9 3D tumor model – a platform for anticancer drug development 213
- Index 241
Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
- List of contributing authors XIII
- 1 Personalized and targeted therapies 1
- 2 Advancements in cancer chemotherapy 27
- 3 Principles of radiation therapy 51
- 4 Advanced cell culture techniques for cancer research 81
- 5 Natural substances in cancer—do they work? 103
- 6 The application of the natural killer cells, macrophages and dendritic cells in treating various types of cancer 137
- 7 Non-radioactive imaging strategies for in vivo immune cell tracking 173
- 8 Present trends in the encapsulation of anticancer drugs 193
- 9 3D tumor model – a platform for anticancer drug development 213
- Index 241
