Startseite Flavonoids Purified from Parsley Inhibit Human Blood Platelet Aggregation and Adhesion to Collagen under Flow
Artikel
Lizenziert
Nicht lizenziert Erfordert eine Authentifizierung

Flavonoids Purified from Parsley Inhibit Human Blood Platelet Aggregation and Adhesion to Collagen under Flow

  • Dounia Gadi , Mohamed Bnouham , Mohammed Aziz , Abderrahim Ziyyat , Abdelkhaleq Legssyer , Arlette Bruel , Mohamed Berrabah , Chantal Legrand , Françoise Fauvel-Lafeve und Hassane Mekhfi
Veröffentlicht/Copyright: 10. August 2012

Abstract

Introduction: Blood platelets are directly involved in both haemostatic and pathologic thrombotic processes, through their adhesion, secretion and aggregation. In this study, we investigated the effect of genins (aglycone flavonoids without sugar group) isolated from parsley (Petroselinum crispum) leaves in vitro on human platelet aggregation and adhesion to a collagen-coated surface under physiologic flow conditions. Materials and Methods: The aggregation and adhesion studies were monitored after pre-incubation of platelets with genins. Results: Genins inhibited dose dependently aggregation induced by thrombin, ADP and collagen. The strongest effect was observed in collagen induced aggregation (IC50 = 0.08 ± 0.01 mg/ml). The HPLC identification of genins compounds revealed the presence of keampferol, apigenin and other not identified compounds. The aggregation tests showed that these compounds have anti-aggregating activity. In addition, adhesion of human platelets to collagen was greatly decreased (over 75 %) by genins (0.3 mg/ml). While the mechanism by which genins act is unclear, we suggest that these compounds may interfere with a multiple target step in the haemostasis process. Conclusion: These results show that genins isolated from parsley has a potent antiplatelet activity. It may be an important source of beneficial antiplatelet compounds that decrease thrombosis and cardiovascular diseases.

Published Online: 2012-8-10

©2012 Walter de Gruyter GmbH & Co. KG, Berlin/Boston

Artikel in diesem Heft

  1. Research Article
  2. H. Spinosa T. Anders Ameliorates Diabetic Neuropathy in Wistar Albino Rats
  3. Anti-Inflammatory Effects of Shea Butter through Inhibition of Inos, Cox-2, and Cytokines via the Nf-Kb Pathway in Lps-Activated J774 Macrophage Cells
  4. Efficacy of Aphrodisiac Plants towards Improvement in Semen Quality and Motility in Infertile Males
  5. Hydroalcoholic extracts of Indian medicinal plants can help in amelioration from oxidative stress through antioxidant properties
  6. Antioxidant Potential and Protection of Pancreatic ?- cells by Calotropis gigantea in Streptozocin Induced Diabetic Rats
  7. Infectivity of Macrophages and the Histopathology of Cutaneous Lesions, Liver and Spleen is Attenuated by Leaf Extract of Vernonia Amygdalina in Leishmania Major Infected BALB/c Mice
  8. In Vitro 5-LOX Inhibitory and Antioxidant Activities of Extracts and Compounds from the Aerial Parts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm.
  9. Antihyperglycemic and Antihyperlipidemic Effects of n-hexane Fraction from the Hydro-methanolic Extract of Sepals of Salmalia malabarica in Streptozotocin-induced Diabetic Rats
  10. Lycopene an Adjunctive Therapy for Helicobacter Pylori Eradication: a Quasi-Control Trial
  11. Efficacy of Baptisia Tinctoria in the Treatment of Typhoid: Its Possible Role in Inducing Antibody Formation
  12. A Preliminary Study of the Mechanism of Hypoglycaemic Activity of Nauclea latifolia Leaf Ethanolic Extract
  13. The Microalga Spirulina platensis Presents Anti-inflammatory Action as well as Hypoglycemic and Hypolipidemic Properties in Diabetic Rats
  14. Evaluation of Antiulcer Potential of Mimusops hexandra in Experimental Gastro Duodenal Ulcers
  15. Flavonoids Purified from Parsley Inhibit Human Blood Platelet Aggregation and Adhesion to Collagen under Flow
  16. Potentiation of Etoposide and Temozolomide Cytotoxicity by Curcumin and Turmeric Force in Brain Tumor Cell Lines
  17. Glucose metabolism and diabetogenic gene expression analysis of chloroform fraction of Andrographis paniculata (Nees) whole herb in diabetic albino mice
  18. Anti-hyperlipidemic Activity of Cucumis Melo Fruit Peel Extracts in High Cholesterol Diet Induced Hyperlipidemia in Rats
  19. Sphaeranthus indicus Flower Derived Constituents Exhibits Synergistic Effect against Acetylcholinesterase and Possess Potential Antiamnestic Activity
  20. Comparison of effectiveness in antitumor activity between flavonoids and polyphenols of the methanolic extract of roots of Potentilla fulgens in breast cancer cells
  21. An Initial Investigation into the Anti-inflammatory Activity and Antioxidant Capacity of alpha-Cyclodextrin-Complexed Manuka Honey
  22. In vivo Antioxidant and Vasodilating Activities of Gmelina arborea (Verberaceae) Leaves Hexane Extract
  23. The Effects of Supplemental Fish Oil on Blood Pressure and Morning Cortisol in Normotensive Adults: a Pilot Study
  24. Effect of Smilax zeylanica roots and rhizomes in paracetamol induced hepatotoxicity
  25. The Antidiabetic Activities of the Methanolic Root Bark Extract of Afzelia africana in Alloxan-Induced Diabetic Mice
  26. Long-Term Treatment with a Health Product (Squina Diacylglyceryl Ether) Enhances Innate and Adaptive Immunity in Mice
  27. Review Article
  28. Glucosinolates: The Phytochemicals of Nutraceutical Importance
  29. Conference Presentation
  30. *Abstracts - 7th IN-CAM Research Symposium, Evaluating CAM Practices: Effectiveness, Integration, Economics & Safety - November 2012
  31. Discussion Paper
  32. Using Role Substitution To Address The Health Workforce Shortage And To Facilitate Integration?
  33. Short Communication on Medicinal Herbs
  34. Contractile Effect of Radish and Betel Nut Extracts on Rabbit Gallbladder
  35. A New Generation of Complementary Medicine Users?
  36. Pharmacological Evaluation of Fruits of Terminalia belerica Roxb. for Antiulcer Activity
Heruntergeladen am 9.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/1553-3840.1579/html
Button zum nach oben scrollen