Article
Licensed
Unlicensed
Requires Authentication
Evaluation of Antiulcer Potential of Mimusops hexandra in Experimental Gastro Duodenal Ulcers
-
Karuna P. Modi
Published/Copyright:
August 10, 2012
Abstract
The study was aimed to investigate antiulcer effects of acetone extract and its different fractions Mimusops hexandra against experimental gastro-duodenal ulcers. 80% acetone extract of stem bark of Mimusops hexandra (Extract A, p.o.) and its different fractions namely diethyl ether (Extract A1, p.o.), ethyl acetate (Extract A2, p.o.) and aqueous (Extract A3, p.o.) were tested for the presence of preliminary phytoconstituents and were screened for their antiulcer potential in experimental animals using ethanol-HCl and aspirin-induced gastric damage at the dose of 500 mg kg–1p.o. Extract A2 being the most active fraction amongst all the fractions tested was also studied at different doses to find its ED50. Further, to establish the mechanism of action, Extract A2 was also tested for its effects in acetic acid-induced gastric ulcer models and cysteamine-induced duodenal ulcer. The effect was compared with cimetidine. Flavonoids (quercetin), procyanidins, saponins and triterpenoids were found to be present in bark. Oral administration of Extract A2 inhibited formation of gastric lesions induced by aspirin in a dose dependent manner. Elevated level of lipid peroxidation due to ethanol-HCl and aspirin induced gastric damage was significantly (p<0.05) reduced by the treatment with Extract A2. Further, Extract A2 at the dose of 100 mg kg-1 (p.o.) reduced extent of acetic acid induced gastric ulcer in experimental animals. Moreover, protection afforded by Extract A2 against cysteamine-induced duodenal lesions was evident from dose dependent decrease in ulcer index (p<0.05), score for intensity (p<0.05) and total lesion area (p<0.05), when compared with the control group. The antiulcer activity shown by Extract A2 in experimental gastro-duodenal ulcer could be attributed to decrease in gastric acid secretory activity along with strengthening of mucosal defensive mechanisms.
Keywords: Mimusops hexandra; sapotaceae; aspirin; ethanol HCl; acetic acid; cysteamine gastric ulcer; duodenal ulcer
Published Online: 2012-8-10
©2012 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Research Article
- H. Spinosa T. Anders Ameliorates Diabetic Neuropathy in Wistar Albino Rats
- Anti-Inflammatory Effects of Shea Butter through Inhibition of Inos, Cox-2, and Cytokines via the Nf-Kb Pathway in Lps-Activated J774 Macrophage Cells
- Efficacy of Aphrodisiac Plants towards Improvement in Semen Quality and Motility in Infertile Males
- Hydroalcoholic extracts of Indian medicinal plants can help in amelioration from oxidative stress through antioxidant properties
- Antioxidant Potential and Protection of Pancreatic ?- cells by Calotropis gigantea in Streptozocin Induced Diabetic Rats
- Infectivity of Macrophages and the Histopathology of Cutaneous Lesions, Liver and Spleen is Attenuated by Leaf Extract of Vernonia Amygdalina in Leishmania Major Infected BALB/c Mice
- In Vitro 5-LOX Inhibitory and Antioxidant Activities of Extracts and Compounds from the Aerial Parts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm.
- Antihyperglycemic and Antihyperlipidemic Effects of n-hexane Fraction from the Hydro-methanolic Extract of Sepals of Salmalia malabarica in Streptozotocin-induced Diabetic Rats
- Lycopene an Adjunctive Therapy for Helicobacter Pylori Eradication: a Quasi-Control Trial
- Efficacy of Baptisia Tinctoria in the Treatment of Typhoid: Its Possible Role in Inducing Antibody Formation
- A Preliminary Study of the Mechanism of Hypoglycaemic Activity of Nauclea latifolia Leaf Ethanolic Extract
- The Microalga Spirulina platensis Presents Anti-inflammatory Action as well as Hypoglycemic and Hypolipidemic Properties in Diabetic Rats
- Evaluation of Antiulcer Potential of Mimusops hexandra in Experimental Gastro Duodenal Ulcers
- Flavonoids Purified from Parsley Inhibit Human Blood Platelet Aggregation and Adhesion to Collagen under Flow
- Potentiation of Etoposide and Temozolomide Cytotoxicity by Curcumin and Turmeric Force in Brain Tumor Cell Lines
- Glucose metabolism and diabetogenic gene expression analysis of chloroform fraction of Andrographis paniculata (Nees) whole herb in diabetic albino mice
- Anti-hyperlipidemic Activity of Cucumis Melo Fruit Peel Extracts in High Cholesterol Diet Induced Hyperlipidemia in Rats
- Sphaeranthus indicus Flower Derived Constituents Exhibits Synergistic Effect against Acetylcholinesterase and Possess Potential Antiamnestic Activity
- Comparison of effectiveness in antitumor activity between flavonoids and polyphenols of the methanolic extract of roots of Potentilla fulgens in breast cancer cells
- An Initial Investigation into the Anti-inflammatory Activity and Antioxidant Capacity of alpha-Cyclodextrin-Complexed Manuka Honey
- In vivo Antioxidant and Vasodilating Activities of Gmelina arborea (Verberaceae) Leaves Hexane Extract
- The Effects of Supplemental Fish Oil on Blood Pressure and Morning Cortisol in Normotensive Adults: a Pilot Study
- Effect of Smilax zeylanica roots and rhizomes in paracetamol induced hepatotoxicity
- The Antidiabetic Activities of the Methanolic Root Bark Extract of Afzelia africana in Alloxan-Induced Diabetic Mice
- Long-Term Treatment with a Health Product (Squina Diacylglyceryl Ether) Enhances Innate and Adaptive Immunity in Mice
- Review Article
- Glucosinolates: The Phytochemicals of Nutraceutical Importance
- Conference Presentation
- *Abstracts - 7th IN-CAM Research Symposium, Evaluating CAM Practices: Effectiveness, Integration, Economics & Safety - November 2012
- Discussion Paper
- Using Role Substitution To Address The Health Workforce Shortage And To Facilitate Integration?
- Short Communication on Medicinal Herbs
- Contractile Effect of Radish and Betel Nut Extracts on Rabbit Gallbladder
- A New Generation of Complementary Medicine Users?
- Pharmacological Evaluation of Fruits of Terminalia belerica Roxb. for Antiulcer Activity
Keywords for this article
Mimusops hexandra;
sapotaceae;
aspirin;
ethanol HCl;
acetic acid;
cysteamine gastric ulcer;
duodenal ulcer
Articles in the same Issue
- Research Article
- H. Spinosa T. Anders Ameliorates Diabetic Neuropathy in Wistar Albino Rats
- Anti-Inflammatory Effects of Shea Butter through Inhibition of Inos, Cox-2, and Cytokines via the Nf-Kb Pathway in Lps-Activated J774 Macrophage Cells
- Efficacy of Aphrodisiac Plants towards Improvement in Semen Quality and Motility in Infertile Males
- Hydroalcoholic extracts of Indian medicinal plants can help in amelioration from oxidative stress through antioxidant properties
- Antioxidant Potential and Protection of Pancreatic ?- cells by Calotropis gigantea in Streptozocin Induced Diabetic Rats
- Infectivity of Macrophages and the Histopathology of Cutaneous Lesions, Liver and Spleen is Attenuated by Leaf Extract of Vernonia Amygdalina in Leishmania Major Infected BALB/c Mice
- In Vitro 5-LOX Inhibitory and Antioxidant Activities of Extracts and Compounds from the Aerial Parts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm.
- Antihyperglycemic and Antihyperlipidemic Effects of n-hexane Fraction from the Hydro-methanolic Extract of Sepals of Salmalia malabarica in Streptozotocin-induced Diabetic Rats
- Lycopene an Adjunctive Therapy for Helicobacter Pylori Eradication: a Quasi-Control Trial
- Efficacy of Baptisia Tinctoria in the Treatment of Typhoid: Its Possible Role in Inducing Antibody Formation
- A Preliminary Study of the Mechanism of Hypoglycaemic Activity of Nauclea latifolia Leaf Ethanolic Extract
- The Microalga Spirulina platensis Presents Anti-inflammatory Action as well as Hypoglycemic and Hypolipidemic Properties in Diabetic Rats
- Evaluation of Antiulcer Potential of Mimusops hexandra in Experimental Gastro Duodenal Ulcers
- Flavonoids Purified from Parsley Inhibit Human Blood Platelet Aggregation and Adhesion to Collagen under Flow
- Potentiation of Etoposide and Temozolomide Cytotoxicity by Curcumin and Turmeric Force in Brain Tumor Cell Lines
- Glucose metabolism and diabetogenic gene expression analysis of chloroform fraction of Andrographis paniculata (Nees) whole herb in diabetic albino mice
- Anti-hyperlipidemic Activity of Cucumis Melo Fruit Peel Extracts in High Cholesterol Diet Induced Hyperlipidemia in Rats
- Sphaeranthus indicus Flower Derived Constituents Exhibits Synergistic Effect against Acetylcholinesterase and Possess Potential Antiamnestic Activity
- Comparison of effectiveness in antitumor activity between flavonoids and polyphenols of the methanolic extract of roots of Potentilla fulgens in breast cancer cells
- An Initial Investigation into the Anti-inflammatory Activity and Antioxidant Capacity of alpha-Cyclodextrin-Complexed Manuka Honey
- In vivo Antioxidant and Vasodilating Activities of Gmelina arborea (Verberaceae) Leaves Hexane Extract
- The Effects of Supplemental Fish Oil on Blood Pressure and Morning Cortisol in Normotensive Adults: a Pilot Study
- Effect of Smilax zeylanica roots and rhizomes in paracetamol induced hepatotoxicity
- The Antidiabetic Activities of the Methanolic Root Bark Extract of Afzelia africana in Alloxan-Induced Diabetic Mice
- Long-Term Treatment with a Health Product (Squina Diacylglyceryl Ether) Enhances Innate and Adaptive Immunity in Mice
- Review Article
- Glucosinolates: The Phytochemicals of Nutraceutical Importance
- Conference Presentation
- *Abstracts - 7th IN-CAM Research Symposium, Evaluating CAM Practices: Effectiveness, Integration, Economics & Safety - November 2012
- Discussion Paper
- Using Role Substitution To Address The Health Workforce Shortage And To Facilitate Integration?
- Short Communication on Medicinal Herbs
- Contractile Effect of Radish and Betel Nut Extracts on Rabbit Gallbladder
- A New Generation of Complementary Medicine Users?
- Pharmacological Evaluation of Fruits of Terminalia belerica Roxb. for Antiulcer Activity
