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An efficient method for the preparation of benzyl γ-ketohexanoates

  • Muhammad Iqbal EMAIL logo , Imam Baloch and Musa Baloch
Published/Copyright: January 9, 2013
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Abstract

Twenty acid chlorides, 4-(mono/di-benzyloxy)-4-ketobutanoyl chlorides (Ia–XXa) were synthesised by the reaction of monoesters of succinic acid with thionyl chloride. The product thus obtained (4-benzyloxy-4-ketobutanoyl chlorides) was treated with diethylcadmium to convert it into the corresponding keto-esters (Ib–XXb), the mono/di-benzyl-γ-ketohexanoates, with a good yield. All the compounds thus prepared were characterised by physical, spectroscopic (UV-VIS, IR, 1H NMR, 13C NMR), and mass measurements techniques.

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Published Online: 2013-1-9
Published in Print: 2013-4-1

© 2012 Institute of Chemistry, Slovak Academy of Sciences

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