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Radioiodination, diagnostic nuclear imaging and bioevaluation of olmesartan as a tracer for cardiac imaging

  • H. M. Sanad and Alhussein A. Ibrahim EMAIL logo
Published/Copyright: June 29, 2018
Radiochimica Acta
From the journal Radiochimica Acta Volume 106 Issue 10

Abstract

The present work has been oriented to prepare radioiodinated olmesartan for a potential cardiac imaging. Olmesartan has been labeled using 125I or 131I with N-bromosuccinimide (NBS) as an oxidizing agent. Many factors like amount of N-bromosuccinimide, amount of substrate, pH, reaction temperature and reaction time, have been systematically studied to optimize high yield of [125I]iodoolmesartan. The biological distribution indicates the suitability of [125I]iodoolmesartan as a novel tracer to image heart.

Keywords: Radioiodination; olmesartan; biological distribution; heart imaging

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Received: 2018-03-26
Accepted: 2018-04-30
Published Online: 2018-06-29
Published in Print: 2018-10-25

©2018 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Determination of the stability constants of Pu(VI) carbonate complexes by capillary electrophoresis coupled with inductively coupled plasma mass spectrometer
  3. Sequential analysis of uranium and plutonium in environmental matrices by extractive liquid scintillation spectrometry
  4. A review of the analytical methodology to determine Radium-226 and Radium-228 in drinking waters
  5. Redox sorption of Ce(III)/Ce(IV) on potassium bismuthate
  6. Radioiodination, diagnostic nuclear imaging and bioevaluation of olmesartan as a tracer for cardiac imaging
  7. Synthesis of isotope – labeled selective PDE5 inhibitor sildenafil (UK 92480-10)
  8. Effect of gamma irradiation on the structure characteristics and mass attenuation coefficient of MgO nanoparticles
  9. Evaluation of gamma-ray attenuation properties of lithium borate glasses doped with barite, limonite and serpentine
  10. Corrigendum
  11. Corrigendum to: Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production
  12. Corrigendum to: Definitions of radioisotope thick target yields
https://doi.org/10.1515/ract-2018-2960
Keywords for this article
Radioiodination; olmesartan; biological distribution; heart imaging

Articles in the same Issue

  1. Frontmatter
  2. Determination of the stability constants of Pu(VI) carbonate complexes by capillary electrophoresis coupled with inductively coupled plasma mass spectrometer
  3. Sequential analysis of uranium and plutonium in environmental matrices by extractive liquid scintillation spectrometry
  4. A review of the analytical methodology to determine Radium-226 and Radium-228 in drinking waters
  5. Redox sorption of Ce(III)/Ce(IV) on potassium bismuthate
  6. Radioiodination, diagnostic nuclear imaging and bioevaluation of olmesartan as a tracer for cardiac imaging
  7. Synthesis of isotope – labeled selective PDE5 inhibitor sildenafil (UK 92480-10)
  8. Effect of gamma irradiation on the structure characteristics and mass attenuation coefficient of MgO nanoparticles
  9. Evaluation of gamma-ray attenuation properties of lithium borate glasses doped with barite, limonite and serpentine
  10. Corrigendum
  11. Corrigendum to: Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production
  12. Corrigendum to: Definitions of radioisotope thick target yields
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