Synthesis of isotope – labeled selective PDE5 inhibitor sildenafil (UK 92480-10)
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R. Sekhar Bolla
,
Kali Charan Gulipalli
Abstract
Sildenfil a vasodilating agent is a selective inhibitor of cyclic guanosine monophosphate – specific phosphodiesterase type 5 which is used for the treatment of male erectile dysfunction and pulmonary arterial hypertension. We presented a detailed approach for the synthesis of [2H3]sildenafil, [2H8]sildenafil and N-desmethyl [2H8]sildenafil. By using the approach we successfully synthesized [2H3]sildenafil, [2H8]sildenafil and N-desmethyl [2H8]sildenafil with good isotopic abundance.
Acknowledgement
We would like to thank to entire KLEF Chemistry department and RPAC panel for their encouragement and valuable support.
References
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/ract-2018-2925).
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Articles in the same Issue
- Frontmatter
- Determination of the stability constants of Pu(VI) carbonate complexes by capillary electrophoresis coupled with inductively coupled plasma mass spectrometer
- Sequential analysis of uranium and plutonium in environmental matrices by extractive liquid scintillation spectrometry
- A review of the analytical methodology to determine Radium-226 and Radium-228 in drinking waters
- Redox sorption of Ce(III)/Ce(IV) on potassium bismuthate
- Radioiodination, diagnostic nuclear imaging and bioevaluation of olmesartan as a tracer for cardiac imaging
- Synthesis of isotope – labeled selective PDE5 inhibitor sildenafil (UK 92480-10)
- Effect of gamma irradiation on the structure characteristics and mass attenuation coefficient of MgO nanoparticles
- Evaluation of gamma-ray attenuation properties of lithium borate glasses doped with barite, limonite and serpentine
- Corrigendum
- Corrigendum to: Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production
- Corrigendum to: Definitions of radioisotope thick target yields
