No impact of obesity susceptibility loci on weight regain after a lifestyle intervention in overweight children
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Anke Hinney
Abstract
Objective: An obesity risk allele at the NEGR1 locus was shown to be associated with weight regain after a lifestyle intervention in obese adults. Independent confirmation and studies in children are lacking. Therefore, we analyzed the impact of this and 11 additional obesity susceptibility loci on weight regain after a lifestyle intervention in overweight children.
Design and Methods: We longitudinally analyzed the changes in weight status as body mass index standard deviation score (BMI-SDS) in 282 overweight children (10.6±2.5 years, 47% male, BMI 27.1±3.9 kg/m2) both at the end of a 1-year lifestyle intervention and at 1 year after the end of intervention. We genotyped obesity risk single nucleotide polymorphisms (SNPs) derived from genome-wide association studies in or in proximity to the following genes: NEGR1, TNKS, SDCCAG8, FTO, MC4R, TMEM18, PTER, MTCH2, SH2B1, MAF, NPC1, and KCTD15.
Results: The children reduced their BMI-SDS (–0.28±0.35; p<0.001) during intervention and increased their BMI-SDS between the end of intervention and 1 year later (+0.05±0.36; p=0.027). None of the SNPs including NEGR1 was related significantly to weight regain.
Conclusions: We found no evidence for effects of any of the GWAS-based obesity marker alleles on weight regain in the course of 1 year after an intervention.
Author contributions
Anke Hinney, Johannes Hebebrand, and Thomas Reinehr developed the study design. Nina Lass and Barbara Wolters performed the anthropometrical measurements. Carolin Pütter performed the statistical analyses. Harald Grallert and Thomas Illig genotyped the included SNPs. Thomas Reinehr wrote the first draft of the paper. All authors discussed the findings and were involved in the writing of the manuscript.
We thank the children who participated in this study.
Conflict of interest statement
Authors’ conflict of interest disclosure: All authors declare that there is no conflict of interest.
Funding: This work was supported by grants from the German Federal Ministry of Education and Research (BMBF), the National Genome Research Network (NGFNplus; grant number 01GS0820), and the Competence Network Obesity (LARGE; grant number 01 GI0839). The funder had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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©2013 by Walter de Gruyter Berlin Boston
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