A levothyroxine dose recommendation for the treatment of children and adolescents with autoimmune thyroiditis induced hypothyroidism
-
Victoria Ellerbroek
,
Katharina Warncke
Abstract
Objective: To determine a levothyroxine (T4) dose recommendation for the treatment of autoimmune thyroiditis (AIT)-induced hypothyroidism.
Methods: T4 doses in 75 children and adolescents with newly diagnosed AIT were prospectively collected and compared to T4 doses of patients with congenital hypothyroidism (CH, n=22).
Results: Sixty-four patients with AIT and 22 patients with CH were included in the analysis. The thyroid-stimulating hormone declined significantly from 25.8±50.1 to 2.1±1.5 μIU/mL (AIT group; p<0.01) and from 338.7±380.7 to 1.9±1.6 μIU/mL (CH group; p<0.01). The required T4 dose for patients with AIT was 1.5±0.5 μg/kg per day (≥6 to <10 years: 2.0±0.4 μg T4/kg per day; ≥10 to <12 years: 1.6±0.4 μg T4/kg per day; ≥12 to <14 years: 1.5±0.6 μg T4/kg per day; ≥14 years: 1.4±0.6 μg T4/kg per day). It deviated significantly from the CH patients’ mean T4 dose of 2.8±0.7 μg T4/kg per day, p<0.01. CH patients with athyreosis required an average dose of 3.1±0.5 μg T4/kg per day; patients with ectopia, 2.6±0.7 μg T4/kg per day; and patients with dyshormonogenesis, 2.5±0.6 μg T4/kg per day.
Conclusion: Juvenile patients with AIT require significantly lower T4 doses than patients with CH.
References
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Articles in the same Issue
- Masthead
- Masthead
- Review article
- Application of imaging modalities for evaluating neuroblastoma
- Images in pediatric endocrinology
- Lingual thyroid
- Original articles
- A levothyroxine dose recommendation for the treatment of children and adolescents with autoimmune thyroiditis induced hypothyroidism
- Fasting glucagon-like peptide-1 in patients with overt hyperthyroidism and euthyroid congenital hypothyroidism
- Perinatal complications and higher risks of offspring thyroid dysfunction in early childhood of Graves’ disease mothers with euthyroidism
- Clinical characteristics and management of cranial diabetes insipidus in infants
- Desmopressin administration in children with central diabetes insipidus: a retrospective review
- An electronic surveillance system for monitoring the hospital presentation of nutritional vitamin D deficiency in children in Scotland
- Frequency and severity of ketoacidosis at onset of autoimmune type 1 diabetes over the past decade in children referred to a tertiary paediatric care centre: potential impact of a national programme highlighted
- Vitamin D status is associated with early markers of cardiovascular disease in prepubertal children
- Evaluation of bone mineral density in children with type 1 diabetes mellitus
- Observational study of diabetes management in type 1 diabetic school-age children during holiday versus school days
- Relationship of body mass index and GAD65 antibody status on β-cell secretion at diabetes onset in African-American children
- Serum dipeptidyl peptidase 4 activity in children with type 1 diabetes mellitus
- Concomitant autoantibodies in newly diagnosed diabetic children with transient celiac serology or proven celiac disease
- Assessment of user-friendliness of the Norditropin FlexPro for pediatric patients treated with recombinant human growth hormone: results of an open-label user survey
- Cognitive impairment and gray/white matter volume abnormalities in pediatric patients with Turner syndrome presenting with various karyotypes
- Prevalence of metabolic syndrome among urban Indian adolescents and its relation with insulin resistance (HOMA-IR)
- Prevalence of metabolic syndrome in obese Chilean children and association with gene variants of the leptin-melanocortin system
- Evaluation of serum neopterin levels and its relationship with adipokines in pediatric obesity-related nonalcoholic fatty liver disease and healthy adolescents
- Could GSD type I expand the spectrum of disorders with elevated plasma chitotriosidase activity?
- Patient reports
- Treatment of hyperinsulinemic hypoglycemia because of diffuse nesidioblastosis with nifedipine after surgical therapies in a newborn
- Successful subcutaneous glucagon use for persistent hypoglycaemia in congenital hyperinsulinism
- A novel atypical presentation of insulin autoimmune syndrome (Hirata’s disease) in a child
- Diagnosis of septo-optic dysplasia in a neonate with hypernatremia, hypoglycemia, and persistent hypothermia
- Speech and language delay in two children: an unusual presentation of hyperthyroidism
- Lissencephaly presenting with congenital hypothyroidism
- PHEX gene mutation in a Chinese family with six cases of X-linked hypophosphatemic rickets
- Primary hyperparathyroidism as an extremely rare cause of secondary myelofibrosis in childhood
- A family with Camurati-Engelman disease: the role of the missense p.R218C mutation in TGFbeta1 in bones and endocrine glands
- A case of SCNN1A splicing mutation presenting as mild systemic pseudohypoaldosteronism type 1
- Central precocious puberty in a girl with Prader-Willi syndrome
- Type 1 diabetes mellitus in a patient with homozygous sickle cell anemia
- Short communication
- No impact of obesity susceptibility loci on weight regain after a lifestyle intervention in overweight children
- Letter to the Editor
- Reliability and validity of homeostasis model assessment for insulin resistance and β-cell dysfunction in critically ill children with hyperglycemia
