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Prevalence of metabolic syndrome in obese Chilean children and association with gene variants of the leptin-melanocortin system

  • José Suazo , María Isabel Hodgson , Ana María Obregón , Macarena Valladares , Gerardo Weisstaub , Paola Amador and José Luis Santos EMAIL logo
Published/Copyright: July 2, 2013

Abstract

Metabolic syndrome (MS) related to adult type 2 diabetes mellitus and cardiovascular disease is prevalent among obese children/adolescents. Genetic variants of the leptin-melanocortin system have been associated with components of MS. The aim of our study is to estimate the prevalence of MS (according to Cook’s criteria) in a Chilean cross-sectional sample of 259 obese children (47.1% girls, aged 6–12 years), and to assess the association between common genetic variants of leptin-melanocortin pathway genes (LEP, LEPR, POMC, MC3R and MC4R) with components of the MS using logistic regression. We observed an overall MS prevalence of 26.3% (32.2% in girls and 21.1% in boys) in obese Chilean children. No associations were detected between genetic variants of leptin-melanocortin genes and MS components. MS prevalence among our obese children sample is similar to those previously described in Chile, demonstrating the increased risk of diseases in adulthood that obese children carry.


Corresponding author: José Luis Santos, Alameda 340, Gastroenterology Building, 4th floor, Santiago, Chile, Phone: +56-2-3543862, Fax: +56-2-6338298, E-mail:

The authors wish to thanks Dr. Raquel Burrows and Dr. Cecilia Albala, without their collaboration this study would not have been possible. This study was supported by the National Fund for Science and Technology Development of Chile (FONDECYT) grant 1061096.

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Received: 2013-3-6
Accepted: 2013-5-14
Published Online: 2013-07-02
Published in Print: 2013-11-01

©2013 by Walter de Gruyter Berlin Boston

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