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Unveiling the phyto-restorative potential of ethereal distillates for atopic dermatitis: an advanced therapeutic approach

  • Ritchu Babbar , Parth Sharma , Rashmi Arora , Twinkle Sharma , Madhukar Garg , Sumitra Singh , Satyender Kumar and Rakesh K. Sindhu EMAIL logo
Published/Copyright: May 7, 2024
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 22 Issue 2

Abstract

Atopic dermatitis is acknowledged as a vital inflammatory disorder associated with the integumentary system of the body and is characterized by the formation of thick reddish-grey scars and erythema formation on skin, prevalent amidst the populace. Numerous synthetic drugs are available for treatment like antihistamines, immunosuppressants, glucocorticoids etc., but contrarily, essential oil therapy is exclusively lime lighted to favour the purpose. The utilization of available engineered drugs, possess the marked adverse effects owing to prolonged duration of therapy and therefore, essential oils are explored well and proved to exhibit the anti-eczematic, anti-inflammatory and antipruritic properties. Ethereal distillates own the assorted and selective therapeutic properties attributable to presence of bioactive compounds liable to treat this torturous and integumentary disorder, likely lavender oil, patchouli oil, frankincense oil etc., have been found to exert their pharmacological actions by impeding the liberation and action of inflammatory mediators and immunological hyperactivities that are engaged in exacerbating this idiopathic illness. The current attempt provided the update with the aim to bring forth the naturally originated treatment that is pertinent to provide the invulnerable therapy by circumventing the noxious symptoms i.e. erythema formation and inflamed lesions.

Keywords: anti-inflammatory; antioxidant; atopic dermatitis; ethereal distillates; essential oils
Corresponding author: Rakesh K. Sindhu, School of Pharmacy, Sharda University, Greater Noida, Gautam Buddha Nagar, Uttar Pradesh 201310, India, E-mail:

Acknowledgement

The authors are thankful to Chitkara College of Pharmacy, Chitkara University, Punjab, India for providing various resources to complete the current article.

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Competing interests: None.

  5. Research funding: None.

  6. Data availability: Within the manuscript.

References

1. Elias, PM. Stratum corneum defensive functions: an integrated view. J Invest Dermatol 2005;125:183–200. https://doi.org/10.1111/j.0022-202x.2005.23668.x.Search in Google Scholar PubMed

2. Elias, PM, Schmuth, M. Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Curr Allergy Asthma Rep 2009;9:265–72. https://doi.org/10.1097/aci.0b013e32832e7d36.Search in Google Scholar PubMed PubMed Central

3. Bieber, T, Akdis, C, Lauener, R, Traidl-Hoffmann, C, Schmid-Grendelmeier, P, Schäppi, G, et al.. Global allergy forum and 3rd davos declaration (2015): atopic dermatitis/eczema: challenges and opportunities toward precision medicine. Allergy 2016;71:588–92. https://doi.org/10.1111/all.12857.Search in Google Scholar PubMed

4. Amano, H, Negishi, I, Akiyama, H, Ishikawa, O. Psychological stress can trigger atopic dermatitis in NC/Nga mice: an inhibitory effect of corticotropin-releasing factor. Neuropsychopharmacology 2008;33:566–73. https://doi.org/10.1038/sj.npp.1301435.Search in Google Scholar PubMed

5. Guttman-Yassky, E, Nograles, KE, Krueger, JG. Contrasting pathogenesis of atopic dermatitis and psoriasis—part II: immune cell subsets and therapeutic concepts. J Allergy Clin Immunol 2011;127:1420–32. https://doi.org/10.1016/j.jaci.2011.01.054.Search in Google Scholar PubMed

6. Inkeles, MS, Scumpia, PO, Swindell, WR, Lopez, D, Teles, RM, Graeberet, al., et al.. Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis. J Invest Dermatol 2015;135:151–9. https://doi.org/10.1038/jid.2014.352.Search in Google Scholar PubMed PubMed Central

7. Seidenari, S, Giusti, G. Objective assessment of the skin of children affected by atopic dermatitis: a study of pH, capacitance and TEWL in eczematous and clinically uninvolved skin. Acta Derm Venereol 1995;75:429–33. https://doi.org/10.2340/0001555575429433.Search in Google Scholar PubMed

8. Wollenberg, A, Seba, A, Antal, AS. Immunological and molecular targets of atopic dermatitis treatment. Br J Dermatol 2014;170:7–11. https://doi.org/10.1111/bjd.12975.Search in Google Scholar PubMed

9. Sharma, P, Chauhan, D, Bose, S, Kumar, R, Kumar, R, Mittal, A. A review on the role of coconut oil in dermatitis diseases. J Pharmaceut Technol Res Manage 2020;8:73–8. https://doi.org/10.15415/jptrm.2020.82010.Search in Google Scholar

10. Orchard, A, van Vuuren, S. Commercial essential oils as potential antimicrobials to treat skin diseases. Evid base Compl Alternative Med 2017;2017:1–92. https://doi.org/10.1155/2017/4517971.Search in Google Scholar PubMed PubMed Central

11. Pan, SY, Gao, SH, Zhou, SF, Tang, MK, Yu, ZL, Ko, KM. New perspectives on complementary and alternative medicine: an overview and alternative therapy. Alternative Ther Health Med 2012;18:20–36.Search in Google Scholar

12. Makkar, R, Behl, T, Bungau, S, Zengin, G, Mehta, V, Kumar, A, et al.. Nutraceuticals in neurological disorders. Int J Mol Sci 2020;21:4424. https://doi.org/10.3390/ijms21124424.Search in Google Scholar PubMed PubMed Central

13. Deyno, S, Mtewa, AG, Abebe, A, Hymete, A, Makonnen, E, Bazira, J, et al.. Essential oils as topical anti-infective agents: a systematic review and meta-analysis. Compl Ther Med 2019;47:102–224. https://doi.org/10.1016/j.ctim.2019.102224.Search in Google Scholar PubMed

14. Singh, S, Singh, TG. Role of nuclear factor kappa B (NF-KB) signalling in neurodegenerative diseases. Curr Neuropharmacol 2020;18:918–35. https://doi.org/10.2174/1570159x18666200207120949.Search in Google Scholar

15. Schmid, P, Simon, D, Simon, HU, Akdis, CA, Wüthrich, B. Epidemiology, clinical features, and immunology of the “intrinsic”(non-IgE-mediated) type of atopic dermatitis (constitutional dermatitis). Allergy 2001;56:841–9. https://doi.org/10.1034/j.1398-9995.2001.00144.x.Search in Google Scholar PubMed

16. Arora, P, Shiveena, B, Garg, M, Kumari, S, Goyal, A. Curative potency of medicinal plants in management of eczema: a conservative approach. Phytomedicine 2022;2:1–12. https://doi.org/10.1016/j.phyplu.2022.100256.Search in Google Scholar

17. McAleer, MA, Irvine, AD. The multifunctional role of filaggrin in allergic skin disease. J Allergy Clin Immunol 2013;131:280–91. https://doi.org/10.1016/j.jaci.2012.12.668.Search in Google Scholar PubMed

18. Drislane, C, Irvine, AD. The role of filaggrin in atopic dermatitis and allergic disease. Ann Allergy Asthma Immunol 2020;124:36–43. https://doi.org/10.1016/j.anai.2019.10.008.Search in Google Scholar PubMed

19. Seguchi, T, Chang-Yi, C, Kusuda, S, Takahashi, M, Aisu, K, Tezuka, T. Decreased expression of filaggrin in atopic skin. Arch Dermatol Res 1996;288:442–6. https://doi.org/10.1007/s004030050080.Search in Google Scholar

20. Howell, MD, Kim, BE, Gao, P, Grant, AV, Boguniewicz, M, DeBenedetto, A, et al.. Cytokine modulation of atopic dermatitis filaggrin skin expression. J Allergy Clin Immunol 2009;124:R7–12. https://doi.org/10.1016/j.jaci.2009.07.012.Search in Google Scholar PubMed

21. Meng, J, Moriyama, M, Feld, M, Buddenkotte, J, Buhl, T, Szöllősi, A, et al.. New mechanism underlying IL-31–induced atopic dermatitis. J Allergy Clin Immunol 2018;141:1677–89. https://doi.org/10.1016/j.jaci.2017.12.1002.Search in Google Scholar PubMed

22. Hara, J, Higuchi, K, Okamoto, R, Kawashima, M, Imokawa, G. High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis. J Invest Dermatol 2000;115:406–13. https://doi.org/10.1046/j.1523-1747.2000.00072.x.Search in Google Scholar PubMed

23. Suárez, AL, Feramisco, JD, John, KOO, Steinhoff, M. Psychoneuroimmunology of psychological stress and atopic dermatitis: pathophysiologic and therapeutic updates. Acta Derm Venereol 2012;92:7. https://doi.org/10.2340/00015555-1188.Search in Google Scholar PubMed PubMed Central

24. Geoghegan, JA, Irvine, AD, Foster, TJ. Staphylococcus aureus and atopic dermatitis: a complex and evolving relationship. Trends Microbiol 2018;26:484–97. https://doi.org/10.1016/j.tim.2017.11.008.Search in Google Scholar PubMed

25. Wedi, B, Wieczorek, D, Stünkel, T, Breuer, K, Kapp, A. Staphylococcal exotoxins exert proinflammatory effects through inhibition of eosinophil apoptosis, increased surface antigen expression (CD11b, CD45, CD54, and CD69), and enhanced cytokine-activated oxidative burst, thereby triggering allergic inflammatory reactions. J Allergy Clin Immunol 2002;109:477–84. https://doi.org/10.1067/mai.2002.121702.Search in Google Scholar PubMed

26. Spergel, JM. From atopic dermatitis to asthma: the atopic march. Ann Allergy Asthma Immunol 2010;105:99–106. https://doi.org/10.1016/j.anai.2009.10.002.Search in Google Scholar PubMed

27. Ao, X, Yan, H, Huang, M, Xing, W, Ao, LQ, Wu, XF, et al.. Lavender essential oil accelerates lipopolysaccharide-induced chronic wound healing by inhibiting caspase-11-mediated macrophage pyroptosis. Kaohsiung J Med Sci 2023;39:511–52. https://doi.org/10.1002/kjm2.12654.Search in Google Scholar PubMed PubMed Central

28. de Groot, AC, Schmidt, E. Essential oils, part III: chemical composition. Dermatitis 2016;27:161–9. https://doi.org/10.1097/der.0000000000000193.Search in Google Scholar PubMed

29. Elisabetsky, E, Marschner, J, Souza, DO. Effect of linalool on glutamatergic system in the rat cerebral cortex. Neurochem Res 1995;20:461–5. https://doi.org/10.1007/bf00973103.Search in Google Scholar PubMed

30. Pattnaik, S, Subramanyam, VR, Bapaji, M, Kole, CR. Anti-bacterial and antifungal activity of aromatic constituents of essential oil. Microbios 1997;89:39–46.Search in Google Scholar

31. Orton, DI, Wilkinson, JD. Cosmetic allergy. Am J Clin Dermatol 2004;5:327–37. https://doi.org/10.2165/00128071-200405050-00006.Search in Google Scholar PubMed

32. Buckle, J. Use of aromatherapy as a complementary treatment for chronic pain. Alternative Ther Health Med 1999;5:42.Search in Google Scholar

33. Brownfield, A. Aromatherapy in arthritis: a study. Nurs Stand 1998;13:34. https://doi.org/10.7748/ns.13.5.34.s46.Search in Google Scholar PubMed

34. Cavanagh, HMA, Wilkinson, JM. Biological activities of lavender essential oil. Phytother Res 2002;16:301–8. https://doi.org/10.1002/ptr.1103.Search in Google Scholar PubMed

35. Kim, HM, Cho, SH. Lavender oil inhibits immediate-type allergic reactions in mice and rats. J Pharm Pharmacol 1999;51:221–6. https://doi.org/10.1211/0022357991772178.Search in Google Scholar PubMed

36. Anderson, C, Lis-Balchin, M, Kirk-Smith, M. Evaluation of massage with essential oils on childhood atopic eczema. Phytother Res 2000;14:452–6. https://doi.org/10.1002/1099-1573(200009)14:6<452::aid-ptr952>3.0.co;2-4.10.1002/1099-1573(200009)14:6<452::AID-PTR952>3.0.CO;2-4Search in Google Scholar

37. Efferth, T, Oesch, F. Anti-inflammatory and anti-cancer activities of frankincense: targets, treatments and toxicities. Semin Cancer Biol 2022;80:39–57. https://doi.org/10.1016/j.semcancer.2020.01.015.Search in Google Scholar

38. Poeckel, D, Werz, O. Boswellic acids: biological actions and molecular targets. Curr Med Chem 2006;13:3359–69. https://doi.org/10.2174/092986706779010333.Search in Google Scholar

39. Togni, S, Maramaldi, G, Di Pierro, F, Biondi, M. A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis. Clin Cosmet Invest Dermatol 2014;7:321. https://doi.org/10.2147/ccid.s69240.Search in Google Scholar

40. Papoutsaki, M, Costanzo, A. Treatment of psoriasis and psoriatic arthritis. BioDrugs 2013;27:3–12. https://doi.org/10.1007/bf03325637.Search in Google Scholar

41. Langner, MD, Maibach, HI. Pruritus measurement and treatment. Clin Exp Dermatol 2009;34:285–8. https://doi.org/10.1111/j.1365-2230.2009.03218.x.Search in Google Scholar

42. Álvarez-Cuesta, C, Gala Ortiz, G, Rodríguez Díaz, E, Blanco Barrios, S, Galache Osuna, C, Raya Aguado, C, et al.. Occupational asthma and IgE-mediated contact dermatitis from sapele wood. Contact Dermatitis 2004;51:88–98. https://doi.org/10.1111/j.0105-1873.2004.0396a.x.Search in Google Scholar

43. Yoshikawa, M, Morikawa, T, Oominami, H, Matsuda, H. Absolute stereostructures of olibanumols A, B, C, H, I, and J from olibanum, gum-resin of Boswellia carterii, and inhibitors of nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages. Chem Pharm Bull 2009;57:957–64. https://doi.org/10.1248/cpb.57.957.Search in Google Scholar

44. Sohn, A, Frankel, A, Patel, RV, Goldenberg, G. Eczema. Mt Sinai J Med 2011;78:730–9. https://doi.org/10.1002/msj.20289.Search in Google Scholar PubMed

45. Pazyar, N, Yaghoobi, R, Bagherani, N, Kazerouni, A. A review of applications of tea tree oil in dermatology. Int J Dermatol 2013;52:784–90. https://doi.org/10.1111/j.1365-4632.2012.05654.x.Search in Google Scholar PubMed

46. Kim, T, Song, B, Cho, KS, Lee, IS. Therapeutic potential of volatile terpenes and terpenoids from forests for inflammatory diseases. Int J Mol Sci 2020;21:2187. https://doi.org/10.3390/ijms21062187.Search in Google Scholar PubMed PubMed Central

47. Papadopoulos, CJ, Carson, CF, Chang, BJ, Riley, TV. Role of the MexAB-OprM efflux pump of Pseudomonas aeruginosa in tolerance to tea tree (Melaleuca alternifolia) oil and its monoterpene components terpinen-4-ol, 1, 8-cineole, and α-terpineol. Appl Environ Microbiol 2008;74:1932–5. https://doi.org/10.1128/aem.02334-07.Search in Google Scholar

48. Mondello, F, De Bernardis, F, Girolamo, A, Cassone, A, Salvatore, G. In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and-resistant human pathogenic Candida species. BMC Infect Dis 2006;6:1–8. https://doi.org/10.1186/1471-2334-6-158.Search in Google Scholar PubMed PubMed Central

49. Mantle, D, Gok, MA, Lennard, TW. Adverse and beneficial effects of plant extracts on skin and skin disorders. Adverse Drug React Toxicol Rev 2001;20:89–103.Search in Google Scholar

50. Carson, CF, Hammer, KA, Riley, TV. Melaleuca alternifolia (tea tree) oil: a review of antimicrobial and other medicinal properties. Clin Microbiol Rev 2006;19:50–62. https://doi.org/10.1128/cmr.19.1.50-62.2006.Search in Google Scholar

51. Khalil, Z, Pearce, AL, Satkunanathan, N, Storer, E, Finlay-Jones, JJ, Hart, PH. Regulation of wheal and flare by tea tree oil: complementary human and rodent studies. J Invest Dermatol 2004;123:683–90. https://doi.org/10.1111/j.0022-202x.2004.23407.x.Search in Google Scholar

52. Lin, TK, Zhong, L, Santiago, JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. Int J Mol Sci 2017;19:70. https://doi.org/10.3390/ijms19010070.Search in Google Scholar PubMed PubMed Central

53. Mittal, M, Siddiqui, MR, Tran, K, Reddy, SP, Malik, AB. Reactive oxygen species in inflammation and tissue injury. Antioxidants Redox Signal 2014;20:1126–67. https://doi.org/10.1089/ars.2012.5149.Search in Google Scholar PubMed PubMed Central

54. Ziboh, VA, Cho, Y, Mani, I, Xi, S. Biological significance of essential fatty acids/prostanoids/lipoxygenase-derived monohydroxy fatty acids in the skin. Arch Pharm Res 2002;25:747–58. https://doi.org/10.1007/bf02976988.Search in Google Scholar PubMed

55. Bhaskaran, N, Shukla, S, Srivastava, JK, Gupta, S. Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity. Int J Mol Med 2010;26:935–40. https://doi.org/10.3892/ijmm_00000545.Search in Google Scholar PubMed PubMed Central

56. Sah, A, Naseef, PP, Kuruniyan, MS, Jain, GK, Zakir, F, Aggarwal, G. A comprehensive study of therapeutic applications of chamomile. Pharmaceuticals 2022;15:1284. https://doi.org/10.3390/ph15101284.Search in Google Scholar PubMed PubMed Central

57. Lemberkovics, E, Kéry, A, Marczal, G, Simándi, B, Szöke, E. Phytochemical evaluation of essential oils, medicinal plants and their preparations. Acta Pharm Hung 1998;68:141–9.Search in Google Scholar

58. Srivastava, JK, Pandey, M, Gupta, S. Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Life Sci 2009;85:663–9. https://doi.org/10.1016/j.lfs.2009.09.007.Search in Google Scholar PubMed PubMed Central

59. Zari, ST, Zari, TA. A review of four common medicinal plants used to treat eczema. J Med Plants Res 2015;9:702–11. https://doi.org/10.5897/jmpr2015.5831.Search in Google Scholar

60. Srivastava, JK, Shankar, E, Gupta, S. Chamomile: a herbal medicine of the past with a bright future. Mol Med Rep 2010;3:895–901. https://doi.org/10.3892/mmr.2010.377.Search in Google Scholar PubMed PubMed Central

61. Swamy, MK, Sinniah, UR. A comprehensive review on the phytochemical constituents and pharmacological activities of Pogostemon cablin Benth.: an aromatic medicinal plant of industrial importance. Molecules 2015;20:8521–47. https://doi.org/10.3390/molecules20058521.Search in Google Scholar PubMed PubMed Central

62. Chakrapani, P, Venkatesh, K, Singh, BCS, Jyothi, BA, Kumar, P, Amareshwari, P, et al.. Phytochemical, pharmacological importance of Patchouli (Pogostemoncablin (Blanco) Benth) an aromatic medicinal plant. Int J Pharmaceut Sci Rev Res 2013;21:7–15.Search in Google Scholar

63. van Beek, TA, Joulain, D. The essential oil of patchouli, Pogostemon cablin: a review. Flavour Fragrance J 2018;33:6–51. https://doi.org/10.1002/ffj.3418.Search in Google Scholar

64. Liu, ZH, Zhou, DY. Chemical component comparison of essential oil extracted from Pogostemon cablin by supercritical CO2 extraction and steam distillation. J Anhui Agric Sci 2009;37:8816–17.Search in Google Scholar

65. Deliana, F, Illian, DN, Nadirah, S, Sari, F, Khairan, K. Therapeutic effects of Patchouli (Pogostemon cablin) essential oil in relieving eczema symptoms in infants and toddlers: a literature review. J Patchouli Essent Prod 2023;2:1–8. https://doi.org/10.24815/jpeop.v2i1.32073.Search in Google Scholar

66. Xian, YF, Li, YC, Ip, SP, Lin, ZX, Lai, XP, Su, ZR. Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264.7 macrophages. Exp Ther Med 2011;2:545–50. https://doi.org/10.3892/etm.2011.233.Search in Google Scholar PubMed PubMed Central

67. Su, ZQ, Wu, XL, Bao, MJ, Li, CW, Kong, SZ, Su, ZR, et al.. Isolation of (-)-patchouli alcohol from patchouli oil by fractional distillation and crystallization. Trop J Pharmaceut Res 2014;13:359–63. https://doi.org/10.4314/tjpr.v13i3.7.Search in Google Scholar

68. Akhila, A, Nigam, MC. GC-MS analysis of the essential oil of Pogostemon cablin (Patchouli oil). Fitoterapia 1984;55:363–5.Search in Google Scholar

69. Akhila, A, Sharma, PK, Thakur, RS. Biosynthetic relationships of patchouli alcohol, seychellene and cycloseychellene in Pogostemon cablin. Phytochemistry 1988;27:2105–8. https://doi.org/10.1016/0031-9422(88)80105-5.Search in Google Scholar

70. Ivanovic, J, Ristic, M, Skala, D. Supercritical CO2 extraction of Helichrysum italicum: influence of CO2 density and moisture content of plant material. J Supercrit Fluids 2011;57:129–36. https://doi.org/10.1016/j.supflu.2011.02.013.Search in Google Scholar

71. Angioni, A, Barra, A, Arlorio, M, Coisson, JD, Russo, MT, Pirisi, FM, et al.. Chemical composition, plant genetic differences, and antifungal activity of the essential oil of Helichrysum italicum G. Don ssp. microphyllum (Willd) Nym. J Agric Food Chem 2003;51:1030–4. https://doi.org/10.1021/jf025940c.Search in Google Scholar PubMed

72. Sala, A, Recio, MDC, Giner, RM, Máñez, S, Tournier, H, Schinella, G, et al.. Anti-inflammatory and antioxidant properties of Helichrysum italicum. J Pharm Pharmacol 2002;54:365–71. https://doi.org/10.1211/0022357021778600.Search in Google Scholar PubMed

73. Isaac, W, Woolhiser, E, Keime, N, Wasvary, M, Adelman, MJ, Sivesind, TE, et al.. Clinical efficacy of nutritional supplements in atopic dermatitis: systematic review. JMIR Dermatol 2023;6:e40857. https://doi.org/10.2196/40857.Search in Google Scholar PubMed PubMed Central

74. Viegas, DA, Palmeira-de-Oliveira, A, Salgueiro, L, Martinez-de-Oliveira, J, Palmeira-de-Oliveira, R. Helichrysum italicum: from traditional use to scientific data. J Ethnopharmacol 2014;151:54–65. https://doi.org/10.1016/j.jep.2013.11.005.Search in Google Scholar PubMed

75. Patil, SM, Ramu, R, Shirahatti, PS, Shivamallu, C, Amachawadi, RG. A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn. Heliyon 2021;7:1–22. https://doi.org/10.1016/j.heliyon.2021.e07054.Search in Google Scholar PubMed PubMed Central

76. Hosseinzadeh, S, Kukhdan, A, Hosseini, A, Armand, R. The application of Thymus vulgaris in traditional and modern medicine: a review. Global J Pharmacol 2015;9:260–6.Search in Google Scholar

77. Kuete, V, editor. Medicinal spices and vegetables from Africa: therapeutic potential against metabolic, inflammatory, infectious and systemic diseases. Amsterdam: Academic Press; 2017.Search in Google Scholar

78. Basch, E, Ulbricht, C, Hammerness, P, Bevins, A, Sollars, D. Thyme (Thymus vulgaris L.), thymol. J Herb Pharmacother 2004;4:49–67. https://doi.org/10.1300/j157v04n01_07.Search in Google Scholar

79. Borugă, O, Jianu, C, Mişcă, C, Goleţ, I, Gruia, AT, Horhat, FG. Thymus vulgaris essential oil: chemical composition and antimicrobial activity. J. Med. Life 2014;7:56.Search in Google Scholar

80. Gedikoğlu, A, Sökmen, M, Çivit, A. Evaluation of Thymus vulgaris and Thymbra spicata essential oils and plant extracts for chemical composition, antioxidant, and antimicrobial properties. Food Sci Nutr 2019;7:1704–14. https://doi.org/10.1002/fsn3.1007.Search in Google Scholar PubMed PubMed Central

81. Dauqan, EM, Abdullah, A. Medicinal and functional values of thyme (Thymus vulgaris L.) herb. J Appl Biol Biotechnol 2017;5:0–2.Search in Google Scholar

82. Ismaili, R, Lamiri, A, Moustaid, K. Study of anti-eczema activity of essentials oils of Thymus vulgaris, Citrus limonum and Mentha spicata from Morocco [Etude de l’activité anti-eczémateuse des huilesessentielles de Thymus vulgaris, Citrus limonum et Mentha spicata du Maroc]. Int J Innovat Appl Stud 2016;14:113.Search in Google Scholar

83. Henderson, A. Oil blend for skin treatment. United States patent, 8932656B1, 2012.Search in Google Scholar

84. Kavurmaci, M, Tan, M. An aromatherapeutic oil mixture for relieving itching in the treatment of uremia pruritus. WIPO (PCT) patent, WO2017086899A1, 2016.Search in Google Scholar

85. Ali Hashi, A. Enhancement composition. United States patent, 20140248370A1, 2014.Search in Google Scholar

86. Daozhi, W, Shuju, N. Compound Chinese medicinal essential oils for resisting skin aging and preparation method thereof. Chinese patent, 102657587A, 2012.Search in Google Scholar

87. Mazzio, AE, Soliman, KF. Treatment of dyshidrosis (pompholyx) and dry skin disorders. United States patent, 7357950B2, 2004.Search in Google Scholar

88. Florence, T, Gan, D, Hines, M. Topical skin care formulations comprising plant extracts. United States patent, 20210177728A1, 2014.Search in Google Scholar
Received: 2024-04-03
Accepted: 2024-04-11
Published Online: 2024-05-07

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jcim-2024-0103
Keywords for this article
anti-inflammatory; antioxidant; atopic dermatitis; ethereal distillates; essential oils

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. From ancient wisdom to modern practices: transformative potential of digital health innovations in advancing traditional medicine
  4. Reviews
  5. Unveiling the phyto-restorative potential of ethereal distillates for atopic dermatitis: an advanced therapeutic approach
  6. Apitherapy for diabetes mellitus: mechanisms and clinical implications
  7. Unlocking the potential: integrating phytoconstituents and nanotechnology in skin cancer therapy – A comprehensive review
  8. Research Articles
  9. Analgesic activity of aqueous and methanol fruit pulp extracts of Hyphaene thebaica (Arecaceae) (Linn) mart in mice
  10. Behavioral and histopathological insights into phenylthiazolyl-1,3,5-triazines: potential antidepressant candidates in a rat model of depression
  11. Effect of amifostine on apoptotic inflammatory makers in cisplatin induced brain damage in rats
  12. Efficiency of medical leech on experimentally induced incisional wound healing in rats
  13. Ellagic acid mitigates alpha-naphthyl isothiocyanate-induced cholestasis in rats via FXR activation and inflammatory pathway modulation
  14. Exploring the wound healing potential of Ixora coccinea and Rhododendron arboreum formulation: integrating experimental and computational approaches
  15. Phytochemical characterization, biochemical profiling and evaluation of anticancer potential of methanolic extract of Withania somnifera stem
  16. Anticancer effects of Plantago major extract on colorectal and gastric cancer cell lines: an in vitro study and molecular docking analysis
  17. Protective mechanisms of icariin in methotrexate-induced renal damage: role of Nrf2/HO-1 and apoptosis reduction
  18. The active ingredients and mechanism of Zuoqing San in the treatment of sigmoid ulcerative colitis by retention enema
  19. Effect of self-hypnosis on fear and pain of natural childbirth: a randomized controlled trial
  20. Exploring the anticancer potential of Jerantinine A from Tabernaemontana coronaria against prostate, breast, and ovarian cancers: a computational approach
  21. Short Communication
  22. Exploring the impact of herbaceous Apiaceae family plants on primary dysmenorrhea: a systematic review protocol
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