Startseite Unlocking the potential: integrating phytoconstituents and nanotechnology in skin cancer therapy – A comprehensive review
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Unlocking the potential: integrating phytoconstituents and nanotechnology in skin cancer therapy – A comprehensive review

  • Abhishek Tiwari EMAIL logo , Varsha Tiwari EMAIL logo , Ajay Sharma , Arya Lakshmi Marrisetti , Manish Kumar , Ankit Rochani , Deepak Kaushik , Vineet Mittal , Renuka Jyothi S. , Haider Ali , Md Sadique Hussain ORCID logo und Gaurav Gupta
Veröffentlicht/Copyright: 13. Dezember 2024
Journal of Complementary and Integrative Medicine
Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 22 Heft 2

Abstract

Skin carcinoma, which includes basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma, is influenced by various factors such as genetic predisposition, chemical exposures, immune system imbalances, and ultraviolet (UV) radiation. This review delves into the mechanisms behind the development of these cancers, exploring the therapeutic potential of microbial, plant derived compounds and nanoparticles in advancing skin cancer treatments. Special attention is given to the cytotoxic effects of anti-neoplastic agents from microbial sources on different cancer cell lines, particularly melanoma. Additionally, the review highlights the role of phytochemicals – such as quercetin, resveratrol, and curcumin alongside vitamins, terpenoids, and sulforaphane, in management of skin cancers through mechanisms like apoptosis induction and cell cycle regulation. Recent advancements in nanotechnology-based drug delivery systems, including NP and microemulsion formulations, are also discussed for their enhanced ability to specifically target cancer cells. The diverse roles of NPs in skin cancer therapy, especially in terms of targeted drug delivery and immune modulation, are reviewed. These innovative NPs formulations have showed improved skin penetration and tumor-specific delivery, reduced systemic toxicity and enhanced therapeutic effectiveness.

Keywords: skin carcinoma; microbial-derived compounds; plant-derived compounds; nanoparticles; targeted drug delivery; apoptosis induction
Corresponding authors: Dr. Abhishek Tiwari, Department of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, Noida, Uttar Pradesh, India, Amity University Uttar Pradesh, Sector 125, Noida 201313, Uttar Pradesh, India, E-mail: ; and Dr. Varsha Tiwari, Department of Pharmacognosy Chemistry, Amity Institute of Pharmacy, Lucknow Campus, Lucknow , India, Amity University Uttar Pradesh, Sector 125, Noida 201313, Uttar Pradesh, India, E-mail:

Acknowledgments

The authors also express their gratitude to the management of Amity Institute of Pharmacy, Amity University Uttar Pradesh, for providing the facilities necessary for this manuscript.

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: Abhishek Tiwari: Data Curation, Writing – original draft. Md Sadique Hussain: Methodology, Software, Writing – review, and editing. Varsha Tiwari: Data Curation, Writing – original draft. Ajay Sharma: Project administration, Visualization. Deepak Kaushik: Formal analysis, Supervision. Vineet Mittal: Formal analysis, Writing – review & editing. Renuka Jyothi. S: Formal analysis, Supervision. Haider Ali: Data Curation, Visualization. Gaurav Gupta: Validation, Writing – review & editing. Arya Lakshmi Marrisetti: Formal analysis, Visualization. Manish Kumar: Formal analysis, Supervision, Validation. Ankit Rochani: Methodology, Project administration.

  4. Use of Large Language Models, AI and Machine Learning Tools: Throughout the process of preparing this work, the author(s) implemented ChatGPT to refine language and grammar. Following the utilization of the tool, the author(s) meticulously examined and modified the material as necessary, assuming complete accountability for the substance of the publication.

  5. Conflict of interest: Authors state no conflict of interest.

  6. Research funding: None declared.

  7. Data availability: Not applicable.

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Received: 2024-10-01
Accepted: 2024-11-14
Published Online: 2024-12-13

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

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  2. Editorial
  3. From ancient wisdom to modern practices: transformative potential of digital health innovations in advancing traditional medicine
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  7. Unlocking the potential: integrating phytoconstituents and nanotechnology in skin cancer therapy – A comprehensive review
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https://doi.org/10.1515/jcim-2024-0338
Schlagwörter für diesen Artikel
skin carcinoma; microbial-derived compounds; plant-derived compounds; nanoparticles; targeted drug delivery; apoptosis induction

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. From ancient wisdom to modern practices: transformative potential of digital health innovations in advancing traditional medicine
  4. Reviews
  5. Unveiling the phyto-restorative potential of ethereal distillates for atopic dermatitis: an advanced therapeutic approach
  6. Apitherapy for diabetes mellitus: mechanisms and clinical implications
  7. Unlocking the potential: integrating phytoconstituents and nanotechnology in skin cancer therapy – A comprehensive review
  8. Research Articles
  9. Analgesic activity of aqueous and methanol fruit pulp extracts of Hyphaene thebaica (Arecaceae) (Linn) mart in mice
  10. Behavioral and histopathological insights into phenylthiazolyl-1,3,5-triazines: potential antidepressant candidates in a rat model of depression
  11. Effect of amifostine on apoptotic inflammatory makers in cisplatin induced brain damage in rats
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  13. Ellagic acid mitigates alpha-naphthyl isothiocyanate-induced cholestasis in rats via FXR activation and inflammatory pathway modulation
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  15. Phytochemical characterization, biochemical profiling and evaluation of anticancer potential of methanolic extract of Withania somnifera stem
  16. Anticancer effects of Plantago major extract on colorectal and gastric cancer cell lines: an in vitro study and molecular docking analysis
  17. Protective mechanisms of icariin in methotrexate-induced renal damage: role of Nrf2/HO-1 and apoptosis reduction
  18. The active ingredients and mechanism of Zuoqing San in the treatment of sigmoid ulcerative colitis by retention enema
  19. Effect of self-hypnosis on fear and pain of natural childbirth: a randomized controlled trial
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  21. Short Communication
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Heruntergeladen am 5.11.2025 von https://www.degruyterbrill.com/document/doi/10.1515/jcim-2024-0338/html
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