Exploring the impact of herbaceous Apiaceae family plants on primary dysmenorrhea: a systematic review protocol
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Athul T.P.
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Vijaya Lekshmi R.
Abstract
Objectives
Primary dysmenorrhea is a leading cause of job and school absenteeism among young females. Despite its high prevalence, contemporary medicine offers limited treatment options. Herbaceous members of the Apiaceae family, such as Pimpinella anisum L., Anethum sowa L., Cuminum cyminum L., and Foeniculum vulgare Mill., are commonly used in traditional medicine to treat primary dysmenorrhea. Currently, there is no comprehensive assessment of their therapeutic efficacy and safety. This study protocol assesses how effective and safe these herbs are in managing primary dysmenorrhea.
Methods
The following databases will be searched without language restriction until May 2024: Cochrane CENTRAL, PubMed, AYUSH Research Portal, and DHARA, along with grey literature, and other sources. The risk of bias tool (RoB2) will evaluate the validity and applicability of study results. The review will address publication bias by taking appropriate measures. The review will adhere to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines for transparent and systematic reporting.
Results
The review will incorporate randomized controlled trials (RCTs) comparing Apiaceae herbs to no treatment, placebo, medication, or standard care. It is anticipated that these herbs will significantly reduce menstrual pain severity, measured via the visual analogue scale (VAS), and exhibit fewer adverse events than nonsteroidal anti-inflammatory drugs (NSAIDs).
Conclusions
This review aims to compile evidence on the efficacy and safety of Apiaceae herbs for primary dysmenorrhea, highlighting the need for further studies.
PROSPERO Registration number
CRD42024538888.
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Research ethics: Not Applicable.
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Informed consent: Not Applicable.
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Author contributions: ATP, VR, and NVS prepared the manuscript MSD, GR, and TMN coordinated the work MP gave inputs while conducting the review.
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Use of Large Language Models, AI, and Machine Learning Tools: None declared.
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Conflict of interest: Authors declare no conflict of interest
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Research funding: None declared.
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Data availability: Not applicable.
References
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Articles in the same Issue
- Frontmatter
- Editorial
- From ancient wisdom to modern practices: transformative potential of digital health innovations in advancing traditional medicine
- Reviews
- Unveiling the phyto-restorative potential of ethereal distillates for atopic dermatitis: an advanced therapeutic approach
- Apitherapy for diabetes mellitus: mechanisms and clinical implications
- Unlocking the potential: integrating phytoconstituents and nanotechnology in skin cancer therapy – A comprehensive review
- Research Articles
- Analgesic activity of aqueous and methanol fruit pulp extracts of Hyphaene thebaica (Arecaceae) (Linn) mart in mice
- Behavioral and histopathological insights into phenylthiazolyl-1,3,5-triazines: potential antidepressant candidates in a rat model of depression
- Effect of amifostine on apoptotic inflammatory makers in cisplatin induced brain damage in rats
- Efficiency of medical leech on experimentally induced incisional wound healing in rats
- Ellagic acid mitigates alpha-naphthyl isothiocyanate-induced cholestasis in rats via FXR activation and inflammatory pathway modulation
- Exploring the wound healing potential of Ixora coccinea and Rhododendron arboreum formulation: integrating experimental and computational approaches
- Phytochemical characterization, biochemical profiling and evaluation of anticancer potential of methanolic extract of Withania somnifera stem
- Anticancer effects of Plantago major extract on colorectal and gastric cancer cell lines: an in vitro study and molecular docking analysis
- Protective mechanisms of icariin in methotrexate-induced renal damage: role of Nrf2/HO-1 and apoptosis reduction
- The active ingredients and mechanism of Zuoqing San in the treatment of sigmoid ulcerative colitis by retention enema
- Effect of self-hypnosis on fear and pain of natural childbirth: a randomized controlled trial
- Exploring the anticancer potential of Jerantinine A from Tabernaemontana coronaria against prostate, breast, and ovarian cancers: a computational approach
- Short Communication
- Exploring the impact of herbaceous Apiaceae family plants on primary dysmenorrhea: a systematic review protocol
