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Apitherapy for diabetes mellitus: mechanisms and clinical implications

  • EMAIL logo , und
Veröffentlicht/Copyright: 1. Januar 2025
Journal of Complementary and Integrative Medicine
Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 22 Heft 2

Abstract

Introduction

Diabetes mellitus is a complex disease in terms of its causes and pathophysiological processes, it produces a significant impact on health and leads to complications that are difficult to manage.

Content

This review summarizes and analyzes recent advances in the understanding of the mechanisms of diabetes mellitus and how apitherapy affects them. Also present the available clinical evidence on its application.

Summary

Apitherapy (complementary-integral use of beehive products) is a potentially useful therapeutic system with a significant level of evidence. This review shows and analyzes the preclinical and clinical evidence on the use of apitherapy in diabetes mellitus.

Outlook

Apitherapy shows significant effects on epigenetics, chronic inflammation, oxidative stress, metabolic control, dysbiosis, premature cell death and tissue remodeling. Clinical evidence shows an impact on these mechanisms. Apitherapy is a very useful complementary medicine in the treatment of diabetes mellitus.

Keywords: diabetes mellitus; apitherapy; bee venoms; propolis; royal jelly
Corresponding author: Andrés Jagua-Gualdrón, MD, Researcher, Professor, National University of Colombia, Bogota, Colombia; International Institute for Complementary and Alternative Medicine-IIMAN, Bogota, Colombia; and International College of Apitherapy, Kra 13 #59-24 L-135, Bogota, 110231, Colombia, E-mail:

Acknowledgments

The authors would like to extend their gratitude to Jose Roberto Garcia Reyes for his invaluable administrative support in facilitating the completion of this article.

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: Andrés Jagua-Gualdrón. Design of conceptual categories, review of the pathophysiology, and examination of pre-clinical and clinical scientific evidence. Nicolai Andrés García-Reyes. Review of the pathophysiology, and examination of pre-clinical and clinical scientific evidence. Roger Edwin Fernández-Bernal. Review of the pathophysiology and clinical scientific evidence.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interests: The authors state no conflict of interest

  6. Research funding: None declared.

  7. Data availability: Not applicable.

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Received: 2024-10-16
Accepted: 2024-12-09
Published Online: 2025-01-01

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. From ancient wisdom to modern practices: transformative potential of digital health innovations in advancing traditional medicine
  4. Reviews
  5. Unveiling the phyto-restorative potential of ethereal distillates for atopic dermatitis: an advanced therapeutic approach
  6. Apitherapy for diabetes mellitus: mechanisms and clinical implications
  7. Unlocking the potential: integrating phytoconstituents and nanotechnology in skin cancer therapy – A comprehensive review
  8. Research Articles
  9. Analgesic activity of aqueous and methanol fruit pulp extracts of Hyphaene thebaica (Arecaceae) (Linn) mart in mice
  10. Behavioral and histopathological insights into phenylthiazolyl-1,3,5-triazines: potential antidepressant candidates in a rat model of depression
  11. Effect of amifostine on apoptotic inflammatory makers in cisplatin induced brain damage in rats
  12. Efficiency of medical leech on experimentally induced incisional wound healing in rats
  13. Ellagic acid mitigates alpha-naphthyl isothiocyanate-induced cholestasis in rats via FXR activation and inflammatory pathway modulation
  14. Exploring the wound healing potential of Ixora coccinea and Rhododendron arboreum formulation: integrating experimental and computational approaches
  15. Phytochemical characterization, biochemical profiling and evaluation of anticancer potential of methanolic extract of Withania somnifera stem
  16. Anticancer effects of Plantago major extract on colorectal and gastric cancer cell lines: an in vitro study and molecular docking analysis
  17. Protective mechanisms of icariin in methotrexate-induced renal damage: role of Nrf2/HO-1 and apoptosis reduction
  18. The active ingredients and mechanism of Zuoqing San in the treatment of sigmoid ulcerative colitis by retention enema
  19. Effect of self-hypnosis on fear and pain of natural childbirth: a randomized controlled trial
  20. Exploring the anticancer potential of Jerantinine A from Tabernaemontana coronaria against prostate, breast, and ovarian cancers: a computational approach
  21. Short Communication
  22. Exploring the impact of herbaceous Apiaceae family plants on primary dysmenorrhea: a systematic review protocol
https://doi.org/10.1515/jcim-2024-0367
Schlagwörter für diesen Artikel
diabetes mellitus; apitherapy; bee venoms; propolis; royal jelly

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. From ancient wisdom to modern practices: transformative potential of digital health innovations in advancing traditional medicine
  4. Reviews
  5. Unveiling the phyto-restorative potential of ethereal distillates for atopic dermatitis: an advanced therapeutic approach
  6. Apitherapy for diabetes mellitus: mechanisms and clinical implications
  7. Unlocking the potential: integrating phytoconstituents and nanotechnology in skin cancer therapy – A comprehensive review
  8. Research Articles
  9. Analgesic activity of aqueous and methanol fruit pulp extracts of Hyphaene thebaica (Arecaceae) (Linn) mart in mice
  10. Behavioral and histopathological insights into phenylthiazolyl-1,3,5-triazines: potential antidepressant candidates in a rat model of depression
  11. Effect of amifostine on apoptotic inflammatory makers in cisplatin induced brain damage in rats
  12. Efficiency of medical leech on experimentally induced incisional wound healing in rats
  13. Ellagic acid mitigates alpha-naphthyl isothiocyanate-induced cholestasis in rats via FXR activation and inflammatory pathway modulation
  14. Exploring the wound healing potential of Ixora coccinea and Rhododendron arboreum formulation: integrating experimental and computational approaches
  15. Phytochemical characterization, biochemical profiling and evaluation of anticancer potential of methanolic extract of Withania somnifera stem
  16. Anticancer effects of Plantago major extract on colorectal and gastric cancer cell lines: an in vitro study and molecular docking analysis
  17. Protective mechanisms of icariin in methotrexate-induced renal damage: role of Nrf2/HO-1 and apoptosis reduction
  18. The active ingredients and mechanism of Zuoqing San in the treatment of sigmoid ulcerative colitis by retention enema
  19. Effect of self-hypnosis on fear and pain of natural childbirth: a randomized controlled trial
  20. Exploring the anticancer potential of Jerantinine A from Tabernaemontana coronaria against prostate, breast, and ovarian cancers: a computational approach
  21. Short Communication
  22. Exploring the impact of herbaceous Apiaceae family plants on primary dysmenorrhea: a systematic review protocol
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