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Platelet physiology and antiplatelet agents
-
Tim Thijs
and
Katleen Broos
Published/Copyright:
November 5, 2010
Abstract
Apart from the central beneficial role platelets play in hemostasis, they are also involved in atherothrombotic diseases. Here, we review the current knowledge of platelet intracellular signal transduction pathways involved in platelet adhesion, activation, amplification of the activation signal and aggregation, as well as pathways limiting platelet aggregation. A thorough understanding of these pathways allows explanation of the mechanism of action of existing antiplatelet agents, but also helps to identify targets for novel drug development.
Clin Chem Lab Med 2010;48:S3–13.
Keywords: antiplatelet agents; platelet activation; platelet adhesion; platelet aggregation; platelet inhibition
Received: 2010-6-7
Accepted: 2010;-9-5
Published Online: 2010-11-05
Published Online: 2010-11-6
Published in Print: 2010-12-01
©2010 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Editorial
- Special issue of the 10th EFCC Continuous Postgraduate Course in Clinical Chemistry: “New Trends in Classification, Diagnosis and Management of Thrombophilia”, October 2010, Dubrovnik, Croatia
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- Hypercoagulable state, pathophysiology, classification and epidemiology
- Diagnostic algorithm for thrombophilia screening
- Genetic basis of thrombosis
- Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game
- Antithrombin deficiency and its laboratory diagnosis
- Factor V Leiden and FII 20210 testing in thromboembolic disorders
- Hyperhomocysteinemia and thrombophilia
- Pediatric thrombosis
- Thrombophilia screening – at the right time, for the right patient, with a good reason
- Methodological issues of genetic association studies
- Pharmacogenetics guided anticoagulation
Keywords for this article
antiplatelet agents;
platelet activation;
platelet adhesion;
platelet aggregation;
platelet inhibition
Articles in the same Issue
- Editorial
- Special issue of the 10th EFCC Continuous Postgraduate Course in Clinical Chemistry: “New Trends in Classification, Diagnosis and Management of Thrombophilia”, October 2010, Dubrovnik, Croatia
- Reviews
- Platelet physiology and antiplatelet agents
- Hypercoagulable state, pathophysiology, classification and epidemiology
- Diagnostic algorithm for thrombophilia screening
- Genetic basis of thrombosis
- Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game
- Antithrombin deficiency and its laboratory diagnosis
- Factor V Leiden and FII 20210 testing in thromboembolic disorders
- Hyperhomocysteinemia and thrombophilia
- Pediatric thrombosis
- Thrombophilia screening – at the right time, for the right patient, with a good reason
- Methodological issues of genetic association studies
- Pharmacogenetics guided anticoagulation
