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Hyperhomocysteinemia and thrombophilia

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Published/Copyright: November 25, 2010
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 48 Issue s1

Abstract

It is now widely accepted that hyperhomocysteinemia (HHC) is a risk factor for thrombophilia. HHC is the result of either impaired enzyme function or a deficiency of vitamin B (folate, B6, B12), or both, and can be treated with vitamin supplements. Measuring plasma total homocysteine (tHcy) is included in the routine thrombophilia panel in many laboratories, despite having a limited value to the clinician. Many methods are available for tHcy measurements. High-pressure liquid chromatography (HPLC) with fluorescence detection is a widely used method, but is being replaced by more convenient immuno- or enzyme assays. In this paper a general overview on homocysteine is given, with an emphasis on laboratory methods.

Clin Chem Lab Med 2010;48:S89–95.

Keywords: homocysteine; methods; thrombophilia; venous thromboembolism
Corresponding author: Mojca Božič-Mijovski, Department of Vascular Diseases, University Medical Centre, 1000 Ljubljana, Slovenia Phone: +386 1 522 8032, Fax: +386 1 522 8070
Received: 2010-6-3
Accepted: 2010-9-7
Published Online: 2010-11-25
Published in Print: 2010-12-01

©2010 by Walter de Gruyter Berlin New York

Articles in the same Issue

  1. Editorial
  2. Special issue of the 10th EFCC Continuous Postgraduate Course in Clinical Chemistry: “New Trends in Classification, Diagnosis and Management of Thrombophilia”, October 2010, Dubrovnik, Croatia
  3. Reviews
  4. Platelet physiology and antiplatelet agents
  5. Hypercoagulable state, pathophysiology, classification and epidemiology
  6. Diagnostic algorithm for thrombophilia screening
  7. Genetic basis of thrombosis
  8. Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game
  9. Antithrombin deficiency and its laboratory diagnosis
  10. Factor V Leiden and FII 20210 testing in thromboembolic disorders
  11. Hyperhomocysteinemia and thrombophilia
  12. Pediatric thrombosis
  13. Thrombophilia screening – at the right time, for the right patient, with a good reason
  14. Methodological issues of genetic association studies
  15. Pharmacogenetics guided anticoagulation
https://doi.org/10.1515/cclm.2010.365
Keywords for this article
homocysteine; methods; thrombophilia; venous thromboembolism

Articles in the same Issue

  1. Editorial
  2. Special issue of the 10th EFCC Continuous Postgraduate Course in Clinical Chemistry: “New Trends in Classification, Diagnosis and Management of Thrombophilia”, October 2010, Dubrovnik, Croatia
  3. Reviews
  4. Platelet physiology and antiplatelet agents
  5. Hypercoagulable state, pathophysiology, classification and epidemiology
  6. Diagnostic algorithm for thrombophilia screening
  7. Genetic basis of thrombosis
  8. Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game
  9. Antithrombin deficiency and its laboratory diagnosis
  10. Factor V Leiden and FII 20210 testing in thromboembolic disorders
  11. Hyperhomocysteinemia and thrombophilia
  12. Pediatric thrombosis
  13. Thrombophilia screening – at the right time, for the right patient, with a good reason
  14. Methodological issues of genetic association studies
  15. Pharmacogenetics guided anticoagulation
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