Hyperhomocysteinemia and thrombophilia
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Mojca Božič-Mijovski
Abstract
It is now widely accepted that hyperhomocysteinemia (HHC) is a risk factor for thrombophilia. HHC is the result of either impaired enzyme function or a deficiency of vitamin B (folate, B6, B12), or both, and can be treated with vitamin supplements. Measuring plasma total homocysteine (tHcy) is included in the routine thrombophilia panel in many laboratories, despite having a limited value to the clinician. Many methods are available for tHcy measurements. High-pressure liquid chromatography (HPLC) with fluorescence detection is a widely used method, but is being replaced by more convenient immuno- or enzyme assays. In this paper a general overview on homocysteine is given, with an emphasis on laboratory methods.
Clin Chem Lab Med 2010;48:S89–95.
©2010 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Editorial
- Special issue of the 10th EFCC Continuous Postgraduate Course in Clinical Chemistry: “New Trends in Classification, Diagnosis and Management of Thrombophilia”, October 2010, Dubrovnik, Croatia
- Reviews
- Platelet physiology and antiplatelet agents
- Hypercoagulable state, pathophysiology, classification and epidemiology
- Diagnostic algorithm for thrombophilia screening
- Genetic basis of thrombosis
- Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game
- Antithrombin deficiency and its laboratory diagnosis
- Factor V Leiden and FII 20210 testing in thromboembolic disorders
- Hyperhomocysteinemia and thrombophilia
- Pediatric thrombosis
- Thrombophilia screening – at the right time, for the right patient, with a good reason
- Methodological issues of genetic association studies
- Pharmacogenetics guided anticoagulation
Articles in the same Issue
- Editorial
- Special issue of the 10th EFCC Continuous Postgraduate Course in Clinical Chemistry: “New Trends in Classification, Diagnosis and Management of Thrombophilia”, October 2010, Dubrovnik, Croatia
- Reviews
- Platelet physiology and antiplatelet agents
- Hypercoagulable state, pathophysiology, classification and epidemiology
- Diagnostic algorithm for thrombophilia screening
- Genetic basis of thrombosis
- Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game
- Antithrombin deficiency and its laboratory diagnosis
- Factor V Leiden and FII 20210 testing in thromboembolic disorders
- Hyperhomocysteinemia and thrombophilia
- Pediatric thrombosis
- Thrombophilia screening – at the right time, for the right patient, with a good reason
- Methodological issues of genetic association studies
- Pharmacogenetics guided anticoagulation
