Pediatric thrombosis
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Alenka Trampus-Bakija
Abstract
Thrombotic risk factors and thrombosis in children has been receiving increased attention. True idiopathic thrombosis is extremely rare in children. Most patients have a significant underlying medical condition and the presence of a central catheter is the most important risk factor. Children are more likely than adults to have one or more significant genetic abnormality or coagulation deficiency. This review discusses problems concerning the heterogeneity of thrombotic states in children and highlights the importance of understanding the concept of developmental hemostasis. Issues regarding step-wise test selection and the interpretation of results are addressed, as well as basic monitoring of anticoagulant drug effects.
Clin Chem Lab Med 2010;48:S97–104.
©2010 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Editorial
- Special issue of the 10th EFCC Continuous Postgraduate Course in Clinical Chemistry: “New Trends in Classification, Diagnosis and Management of Thrombophilia”, October 2010, Dubrovnik, Croatia
- Reviews
- Platelet physiology and antiplatelet agents
- Hypercoagulable state, pathophysiology, classification and epidemiology
- Diagnostic algorithm for thrombophilia screening
- Genetic basis of thrombosis
- Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game
- Antithrombin deficiency and its laboratory diagnosis
- Factor V Leiden and FII 20210 testing in thromboembolic disorders
- Hyperhomocysteinemia and thrombophilia
- Pediatric thrombosis
- Thrombophilia screening – at the right time, for the right patient, with a good reason
- Methodological issues of genetic association studies
- Pharmacogenetics guided anticoagulation
Articles in the same Issue
- Editorial
- Special issue of the 10th EFCC Continuous Postgraduate Course in Clinical Chemistry: “New Trends in Classification, Diagnosis and Management of Thrombophilia”, October 2010, Dubrovnik, Croatia
- Reviews
- Platelet physiology and antiplatelet agents
- Hypercoagulable state, pathophysiology, classification and epidemiology
- Diagnostic algorithm for thrombophilia screening
- Genetic basis of thrombosis
- Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game
- Antithrombin deficiency and its laboratory diagnosis
- Factor V Leiden and FII 20210 testing in thromboembolic disorders
- Hyperhomocysteinemia and thrombophilia
- Pediatric thrombosis
- Thrombophilia screening – at the right time, for the right patient, with a good reason
- Methodological issues of genetic association studies
- Pharmacogenetics guided anticoagulation
