Pharmacogenetics guided anticoagulation
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Raute Sunder-Plassmann
Abstract
Advances in the field of human genetics has made it possible to develop prevention strategies for rare genetic disorders and to tailor pharmacotherapeutic approaches to anticoagulation and certain cancers. However, it is still not clear how genetic variations influence the risk and outcome of common diseases. Data from genome-wide association studies is just beginning to answer these questions. In contrast, pharmacogenetic knowledge is frequently not yet translated into clinical practice, even though in some cases, particularly regarding drugs used in treatment of thrombotic diseases (e.g., coumarines, platelet aggregation inhibitors), it is already known that testing for genetic variants prior to pharmacotherapy may help to prevent severe adverse drug reactions or avoid therapeutic failure. In this review, we address the potential impact that genetic alterations in the genes for vitamin K epoxide reductase and some cytochrome P450 variants may have on therapeutic strategies in anticoagulation.
Clin Chem Lab Med 2010;48:S119–27.
©2010 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Editorial
- Special issue of the 10th EFCC Continuous Postgraduate Course in Clinical Chemistry: “New Trends in Classification, Diagnosis and Management of Thrombophilia”, October 2010, Dubrovnik, Croatia
- Reviews
- Platelet physiology and antiplatelet agents
- Hypercoagulable state, pathophysiology, classification and epidemiology
- Diagnostic algorithm for thrombophilia screening
- Genetic basis of thrombosis
- Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game
- Antithrombin deficiency and its laboratory diagnosis
- Factor V Leiden and FII 20210 testing in thromboembolic disorders
- Hyperhomocysteinemia and thrombophilia
- Pediatric thrombosis
- Thrombophilia screening – at the right time, for the right patient, with a good reason
- Methodological issues of genetic association studies
- Pharmacogenetics guided anticoagulation
Articles in the same Issue
- Editorial
- Special issue of the 10th EFCC Continuous Postgraduate Course in Clinical Chemistry: “New Trends in Classification, Diagnosis and Management of Thrombophilia”, October 2010, Dubrovnik, Croatia
- Reviews
- Platelet physiology and antiplatelet agents
- Hypercoagulable state, pathophysiology, classification and epidemiology
- Diagnostic algorithm for thrombophilia screening
- Genetic basis of thrombosis
- Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game
- Antithrombin deficiency and its laboratory diagnosis
- Factor V Leiden and FII 20210 testing in thromboembolic disorders
- Hyperhomocysteinemia and thrombophilia
- Pediatric thrombosis
- Thrombophilia screening – at the right time, for the right patient, with a good reason
- Methodological issues of genetic association studies
- Pharmacogenetics guided anticoagulation
