Fabrication of Porous 3-D Structure from Poly(L-lactide)-based Nanocomposite Foam via Enzymatic Degradation
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M. Bitou
Abstract
In order to prepare a porous three-dimensional (3-D) structure in biodegradable polyester materials we have conducted the enzymatic degradation of a poly(L-lactide) (PLLA)-based nano-composite foam, having a nanocellular structure, using proteinase-K as a degrading agent at 37°C. The surface and cross sectional morphologies of the foam recovered after enzymatic hydrolysis for different intervals were investigated by using a scanning electron microscope. The nanocellular material took up a large amount of water, which led to the swelling of the foam due to the large surface area inside the nanocelluar structure, and facilitated the enzymatic degradation of the PLLA matrix as compared with the bulk (pre-foamed) sample. Consequently, we have successfully prepared a porous 3-D structure as a remaining scaffold in the core part of the nano-composite foam, reflecting the spherulites of the crystallized PLLA.
References
Abe, H., et al., “Physical Properties and Enzymatic Degradability of Copolymers of (R)-3-Hydroxybutyric Acid and (S, S) Lactide”, Polymer, 39, 59–67 (1997)10.1016/S0032-3861(97)00240-1Suche in Google Scholar
Cai, Q., et al., “Enzymatic Degradation Behavior and Mechanism of Poly(Lactide-Co-Glycolide) Foams by Trypsin”, Biomaterials, 24, 629–638 (2003)10.1016/S0142-9612(02)00377-0Suche in Google Scholar
Coombes, A. G. A., Meikle, M. C., “Resorbable Synthetic Polymers as Replacements for Bone Graft”, Mater.17, 35 (1994)10.1016/0267-6605(94)90046-9Suche in Google Scholar
Ebeling, W.et al., “Proteinase K from Tritirachium Album Limber”, Eur. J. Biochem., 47, 91–97 (1974)10.1111/j.1432-1033.1974.tb03671.xSuche in Google Scholar
Ema, Y., et al., “Foam Processing and Cellular Structure of Polylactide-based Nanocomposites”, Polymer, 47, 5350–5359 (2006)10.1016/j.polymer.2006.05.050Suche in Google Scholar
Fisher, E. W., et al., “Investigation of the Structure of Solution Grown Crystals of Lactide Copolymers by Means of Chemical Reactions”, Polymer, 25, 980–990 (1973)Suche in Google Scholar
Fujimoto, Y., et al., “Well-controlled Biodegradable Nanocomposite Foams: From Microcellular to Nanocellular”, Macromol. Rapid Commun., 24, 457–461 (2003)10.1002/marc.200390068Suche in Google Scholar
Fukuda, N., et al., “Physical Properties and Enzymatic Hydrolysis of Poly (L-lactide)-CaCO3 Composites”, Polym. Degrad. Stab., 78, 119–127 (2002)10.1016/S0141-3910(02)00125-8Suche in Google Scholar
Gao, F., “Clay/Polymer Composites: The Story”, Materials Today, 7, 50–55 (2004)10.1016/S1369-7021(04)00509-7Suche in Google Scholar
Gedde, U. W., “Polymer Physics”, Chapman & Hall, London (1995)Suche in Google Scholar
Hoedle, S. M., et al., “Supercritical Fluid Mixing: Preparation of Thermally Sensitive Polymer Composites Containing Bioactive Materials”, Chem. Commun. 109–110 (2001)10.1039/b008188oSuche in Google Scholar
Hussain, F., et al., “Review Paper: Polymer-Matrix Nanocomposites, Processing, Manufacturing, and Application: An Overview”, J. Composite Mater., 40, 1511–1575 (2006)10.1177/0021998306067321Suche in Google Scholar
Iwata, T., Doi, Y., “Morphology and Enzymatic Degradation of Poly-(L-lactic acid) Single Crystals”, Macromolecules31, 2461–2467 (1998)10.1021/ma980008hSuche in Google Scholar
Li, S., et al., “Enzymatic Degradation of Polylactide Stereocopolymers with Predominant d-lactyl Contents”, Polym. Degrad. Stab., 71, 61–67 (2001)10.1016/S0141-3910(00)00152-XSuche in Google Scholar
Nam, H., et al., “A Hierarchical Structure and Properties of Intercalated Polypropylene/Clay Nanocomposites”, Polymer, 42, 9633–9640 (2001)10.1016/S0032-3861(01)00512-2Suche in Google Scholar
Nam, J., et al., “Crystallization Behavior and Morphology of Biodegradable Polylactide/Layered Silicate Nanocomposite”, Macromolecules, 36, 7126–7131 (2003)10.1021/ma034623jSuche in Google Scholar
Okada, A,. UsukiA., “Twenty Years of Polymer-Clay Nanocomposites”, Macromol. Mater. Eng., 291, 1449–1476 (2006)10.1002/mame.200600260Suche in Google Scholar
Okamoto, M., “Recent Advances in Polymer/Layered Silicate Nanocomposites: An Overview from Science to Technology”, Mater. Sci. Tech., 22, 756–779 (2006)10.1179/174328406X101319Suche in Google Scholar
Reeve, M. S., et al., “Polyactide Stereochemistry: Effect on Enzymatic Degradability”, Macromolecules, 27, 825 (1994)10.1021/ma00081a030Suche in Google Scholar
Sinha Ray, S., et al., “New Polylactide/Layered Silicate Nanocomposites. 1. Preparation, Characterization, and Properties”, Macromolecules, 35, 3104–3110 (2002a)10.1021/ma011613eSuche in Google Scholar
Sinha Ray, S., et al., “New Polylactide/Layered Silicate Nanocomposite: Nanoscale Control over Multiple Properties”, Macromol. Rapid. Commun., 23, 943–947 (2002b)10.1002/1521-3927(200211)23:16<943::AID-MARC943>3.0.CO;2-FSuche in Google Scholar
Sinha Ray, S., et al., “Polylactide/Layered Silicate Nanocomposite: A Novel Biodegradable Material”, Nano Lett., 2, 1093–1096 (2002c)10.1021/nl0202152Suche in Google Scholar
Sinha Ray, S., Okamoto, M., “Polymer/Layered Silicate Nanocomposites: A Review from Preparation to Processing”, Prog. Polym. Sci., 28, 1539–1641 (2003a)10.1016/j.progpolymsci.2003.08.002Suche in Google Scholar
Sinha Ray, S., et al., “New Polylactide-layered Silicate Nanocomposites. 2. Concurrent Improvements of Material Properties, Biodegradability and Melt Rheology”, Polymer, 44, 857–866 (2003b)10.1016/S0032-3861(02)00818-2Suche in Google Scholar
Sinha Ray, S., et al., “New Polylactide/Layered Silicate Nanocomposites. 5. Designing of Materials with Desired Properties”, Polymer, 44, 6633–6646 (2003c)10.1016/j.polymer.2003.08.021Suche in Google Scholar
Sinha Ray, S., et al., “New Polylactide/Layered Silicate Nanocomposites. 3. High-Performance Biodegradable Materials”, Chem. Mater., 15, 1456–1465 (2003d)10.1021/cm020953rSuche in Google Scholar
Sinha Ray, S., et al., “Control of Biodegradability of Polylactide via Nanocomposite Technology”, Macromol. Mater. Eng., 288, 203–208 (2003e)10.1002/mame.200300156Suche in Google Scholar
Sinha Ray, S., et al., “New Polylactide/Layered Silicate Nanocomposites, 6. a. Melt Rheology and Foam Processing”, Macromol. Mater. Eng., 288, 936–944 (2003f)10.1002/mame.200300156Suche in Google Scholar
Sinha Ray, S., Okamoto, “Biodegradable Polylactide and its Nanocomposites: Opening a New Dimension for Plastics and Composites”, Macromol. Rapid. Commun., 24, 815–840 (2003g)10.1002/marc.200300008Suche in Google Scholar
Tsuji, H., et al., J. “Porous Biodegradable Polyesters. I. Preparation of Porous Poly (L-Iactide) Films by Extraction of Poly(ethylene oxide) from Their Blends”, J. Appl. Polm. Sci., 75, 629–637 (2000)10.1002/(SICI)1097-4628(20000131)75:5<629::AID-APP5>3.0.CO;2-ASuche in Google Scholar
Tsuji, H., Ishizaka, T., “Porous Biodegradable Polyesters: 3. Preparation of Porous Poly(∊-caprolactone) Films from Blends by Selective Enzymatic Removal of Poly(L-lactide)”, Macromol. Biosci., 1, 59–65 (2001)10.1002/1616-5195(20010301)1:2<59::AID-MABI59>3.0.CO;2-6Suche in Google Scholar
Tsuji, H., Miyauchi, S., “Poly(l-lactide): VI Effects of Crystallinity on Enzymatic Hydrolysis of Poly(l-lactide) without Free Amorphous Region”, Polym. Degrad. Stab., 71, 415–424 (2001)10.1016/S0141-3910(00)00191-9Suche in Google Scholar
Vaia, R. A., Wagner, H. D., “Framework for Nanocomposites”, Materials Today, 7, 32–37 (2004)10.1016/S1369-7021(04)00506-1Suche in Google Scholar
Wang, C. H., et al., “Enzymatic Degradation of PLLA-Peoz-PLLA Triblock Copolymers”, Biomaterials, 26, 2803–2811 (2005)10.1016/j.biomaterials.2004.07.064Suche in Google Scholar PubMed
Williams, D. F., “Enzymic Hydrolysis of Polylactic Acid”, Eng. Med., 10, 5–7 (1981)10.1243/EMED_JOUR_1981_010_004_02Suche in Google Scholar
Yoshida, O., Okamoto, M., “Direct Melt Intercalation of Polylactide Chains into Nano-Galleries: Interlayer Expansion and Nanocomposite Structure”, Macromol. Rapid Commun., 27, 751–757 (2006)10.1002/marc.200600080Suche in Google Scholar
Zhang, J., et al., “Crystal Modifications and Thermal Behavior of Poly(L-lactic acid) Revealed by Infrared Spectroscopy”, Macromolecules, 38, 8012–8021 (2005)10.1021/ma051232rSuche in Google Scholar
© 2007, Carl Hanser Verlag, Munich
Artikel in diesem Heft
- Contents
- Contents
- Editorial
- Special Issue on Biobased Polymers
- Invited Papers
- Crystallization and Mechanical Propertiesof Poly (D, L) Lactide-based Blown Films
- Rheological Behavior and Modeling of Thermal Degradation of Poly(∊-Caprolactone) and Poly(L-Lactide)
- Rheological Evaluation and Observations of Extrusion Instabilities of Biodegradable Polyesters
- Biaxial Orientation of Polylactide/Thermoplastic Starch Blends
- Effects of Starch Types on Mechanical Properties of Poly(lactic acid)/Starch Composites
- Solid and Microcellular Polylactide-Carbon Nanotube Nanocomposites
- Tapioca Starch-poly (lactic acid)-based Nanocomposite Foams as Affected by Type of Nanoclay
- Injection Molded Solid and Microcellular Polylactide Compounded with Recycled Paper Shopping Bag Fibers
- Fabrication of Porous 3-D Structure from Poly(L-lactide)-based Nanocomposite Foam via Enzymatic Degradation
- The Linear Viscoelastic Behavior of a Series of 3-Hydroxybutyrate-based Copolymers
- New Developments in Biodegradable Starch-based Nanocomposites
- Viscous Properties of Thermoplastic Starches from Different Botanical Origin
- Thermoplastic Foams from Zein and Gelatin
- Improvement of the Mechanical Properties of Soy Protein Isolate Based Plastics through Formulation and Processing
- Biocomposites Based on Bacterial Cellulose and Apple and Radish Pulp
- Preparation and Properties of Metallocene-catalyzed PE/Starch Nanocomposites: Role of Nanocompatibilizer
- Evaluation of Properties and Biodeterioration Potential of Polyethylene and Aliphatic Polyester Blends
- PPS News
- PPP News
- Seikei-Kakou Abstracts
- Seikei-Kakou Abstracts
Artikel in diesem Heft
- Contents
- Contents
- Editorial
- Special Issue on Biobased Polymers
- Invited Papers
- Crystallization and Mechanical Propertiesof Poly (D, L) Lactide-based Blown Films
- Rheological Behavior and Modeling of Thermal Degradation of Poly(∊-Caprolactone) and Poly(L-Lactide)
- Rheological Evaluation and Observations of Extrusion Instabilities of Biodegradable Polyesters
- Biaxial Orientation of Polylactide/Thermoplastic Starch Blends
- Effects of Starch Types on Mechanical Properties of Poly(lactic acid)/Starch Composites
- Solid and Microcellular Polylactide-Carbon Nanotube Nanocomposites
- Tapioca Starch-poly (lactic acid)-based Nanocomposite Foams as Affected by Type of Nanoclay
- Injection Molded Solid and Microcellular Polylactide Compounded with Recycled Paper Shopping Bag Fibers
- Fabrication of Porous 3-D Structure from Poly(L-lactide)-based Nanocomposite Foam via Enzymatic Degradation
- The Linear Viscoelastic Behavior of a Series of 3-Hydroxybutyrate-based Copolymers
- New Developments in Biodegradable Starch-based Nanocomposites
- Viscous Properties of Thermoplastic Starches from Different Botanical Origin
- Thermoplastic Foams from Zein and Gelatin
- Improvement of the Mechanical Properties of Soy Protein Isolate Based Plastics through Formulation and Processing
- Biocomposites Based on Bacterial Cellulose and Apple and Radish Pulp
- Preparation and Properties of Metallocene-catalyzed PE/Starch Nanocomposites: Role of Nanocompatibilizer
- Evaluation of Properties and Biodeterioration Potential of Polyethylene and Aliphatic Polyester Blends
- PPS News
- PPP News
- Seikei-Kakou Abstracts
- Seikei-Kakou Abstracts