Startseite Aminohydroxylation of divinylcarbinol and its application to the synthesis of bicyclic hydroxypyrrolidine and aminotetrahydrofuran building blocks
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Aminohydroxylation of divinylcarbinol and its application to the synthesis of bicyclic hydroxypyrrolidine and aminotetrahydrofuran building blocks

  • Oľga Caletková EMAIL logo , Diana Ďurišová , Naďa Prónayová und Tibor Gracza
Veröffentlicht/Copyright: 20. September 2012
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Abstract

Aminohydroxylation of prochiral divinylcarbinol and subsequent Pd(II)-catalysed oxy-/amidocarbonylation of aminopentenediols is reported. The method was applied to the preparation of useful building blocks for syntheses of cytotoxic jaspines and glycosidase inhibitor DLX-homologues. The key intermediates, tetrahydrofuranolactones (l-arabino-II) and pyrrolidinolactones (l-arabino-IX and l-xylo-IX), were prepared in a short 2-step sequence from divinylcarbinol.

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Published Online: 2012-9-20
Published in Print: 2013-1-1

© 2012 Institute of Chemistry, Slovak Academy of Sciences

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