Startseite Contribution of hyphenated CE-ICP/MS in metal/protein interactions studies
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Contribution of hyphenated CE-ICP/MS in metal/protein interactions studies

  • J. Chamoun und A. Hagège
Veröffentlicht/Copyright: 17. Dezember 2007

Summary

By introducing a preliminary in-capillary preconcentration step, CE-ICP/MS was applied to trace metal speciation in proteins. Emphasis was put on metal/protein interactions where CE-ICP/MS is demonstrated to provide informations concerning metal binding and metal exchanges occuring in proteins. Preliminary studies on the fate of several metals in the presence of a mixture of standard proteins were performed. Cadmium was shown to bind mainly to albumin and ceruloplasmin. Cobalt and nickel were detected only in carbonic anhydrase and ceruloplasmin in the mixture of proteins but also in albumin when injected alone.

Received: 2005-1-3
Accepted: 2005-7-4
Published Online: 2007-12-17
Published in Print: 2005-11-1

© Oldenbourg Wissenschaftsverlag, München

Heruntergeladen am 22.10.2025 von https://www.degruyterbrill.com/document/doi/10.1524/ract.2005.93.11.659/html
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