Amidoxime functionalized mesoporous silica nanoparticles for pH-responsive delivery of anticancer drug
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Madhappan Santhamoorthy
,
Ranganathan Suresh
und
Seong-Cheol Kim
Abstract
In recent decades, nanomedicine has attracted much attention at the forefront of nanotechnology, gaining great expectations in the biomedical sectors. Among various nanomaterials, silica nanoparticles-based drug delivery is considered effective owing to their physicochemical stability and biological compatibility. Surface grafting and chemical conversion techniques were used to create an amphoteric functional ligand known as amidoxime ligand (AL) modified mesoporous silica material (MS-AL NPs). With this technique, amidoxime ligand groups can be introduced in greater concentration to the silica surface without compromising its structure. The active surface allows for surface functionalization and integration of medicinal substances. They are widely employed in the bio-medical industry for diagnostics, target administration of drugs, bio-sensing, cellular absorption, and so on. The function of the produced MS-AL NPs as a regulated drug delivery system was studied utilizing doxorubicin (Dox) as a model anticancer drug. Using the MCF-7 cell line, the biocompatibility and cellular uptake characteristics were investigated. Considering all factors, the MS-AL NPs may be used as pH-responsive drug carriers in cancer treatment applications.
Funding source: The Ministry of Education, Republic of Korea
Award Identifier / Grant number: 2020R1I1A3052258
Funding source: King Saud University, Riyadh, Saudi Arabia
Award Identifier / Grant number: RSPD2024R675
Acknowledgments
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2020R1I1A3052258). Authors acknowledge the Researchers Supporting Project number (RSPD2024R675), King Saud University, Riyadh, Saudi Arabia for supporting this project.
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Research ethics: Not applicable.
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Author contributions: Conceptualization, methodology, validation, and formal analysis: Madhappan Santhamoorthy, Ranganathan Suresh, Vanaraj Ramkumar. Resources, data curation: Loganathan Guganathan, Kokila Thirupathi. Writing—original draft preparation, Madhappan Santhamoorthy, Anandhu Mohan, Govindasami Periyasami; writing—review and editing. Visualization, supervision: Seong-Cheol Kim. Project administration: Anandhu Mohan and Seong-Cheol Kim. Funding acquisition: Seong-Cheol Kim and Govindasami Periyasami. All authors have read and agreed to the published version of the manuscript.
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Competing interests: The author(s) state(s) no conflict of interest.
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Research funding: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2020R1I1A3052258). The project was also supported by Researchers Supporting Project number (RSPD2024R675), King Saud University, Riyadh, Saudi Arabia.
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Data availability: The raw data can be obtained on request from the corresponding author.
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© 2024 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Contributions to “Materials for Solar Water Splitting”
- Unveiling the role of rare earth dopant in metal molybdate nanocomposites via facile microwave-combustion strategy and their effect on antibacterial activity
- Effect of lanthanum (La) substitution on the magnetic and electrical properties of nickel ferrites: an investigation of its doping concentrations
- The relationship between environmental factors and dust accumulation by machine learning
- Facile formation of STO/gC3N4 hybrid composite to effectively degrade the dye and antibiotic under white light
- Investigation of the composition and morphology of raw materials from the Aral Sea region
- Chemical state and atomic structure in stoichiovariants photochromic oxidized yttrium hydride thin films
- Single crystal of barium bis para-nitrophenolate para-nitrophenol tetrahydrate for NLO applications: crystal growth and DFT analysis
- Characterization of single-crystal phenothiazine synthesized using the vertical Bridgman method
- Amidoxime functionalized mesoporous silica nanoparticles for pH-responsive delivery of anticancer drug
- Exploring optical and electrochemical studies on thulium selenite (TmSeO3)
Artikel in diesem Heft
- Frontmatter
- Contributions to “Materials for Solar Water Splitting”
- Unveiling the role of rare earth dopant in metal molybdate nanocomposites via facile microwave-combustion strategy and their effect on antibacterial activity
- Effect of lanthanum (La) substitution on the magnetic and electrical properties of nickel ferrites: an investigation of its doping concentrations
- The relationship between environmental factors and dust accumulation by machine learning
- Facile formation of STO/gC3N4 hybrid composite to effectively degrade the dye and antibiotic under white light
- Investigation of the composition and morphology of raw materials from the Aral Sea region
- Chemical state and atomic structure in stoichiovariants photochromic oxidized yttrium hydride thin films
- Single crystal of barium bis para-nitrophenolate para-nitrophenol tetrahydrate for NLO applications: crystal growth and DFT analysis
- Characterization of single-crystal phenothiazine synthesized using the vertical Bridgman method
- Amidoxime functionalized mesoporous silica nanoparticles for pH-responsive delivery of anticancer drug
- Exploring optical and electrochemical studies on thulium selenite (TmSeO3)
