Solubilization, Hansen solubility parameters and apparent thermodynamic parameters of Osimertinib in (propylene glycol + water) cosolvent mixtures
-
Faiyaz Shakeel
,
Md. Khalid Anwer
Abstract
The solubilization, Hansen solubility parameters (HSPs) and apparent thermodynamic parameters of a novel anticancer medicine osimertinib (OMT) in binary propylene glycol (P) + water (W) cosolvent mixtures were evaluated. The mole fraction solubility (xe) of OMT in various (P + W) cosolvent mixtures including neat P and neat W was determined at T = 298.2–318.2 K and p = 0.1 MPa by applying a saturation shake flask method. HSPs of OMT, neat P, neat W and (P + W) cosolvent compositions free of OMT were also estimated. The xe values of OMT were regressed with Van’t Hoff, modified Apelblat, Yalkowsky-Roseman, Jouyban-Acree and Jouyban-Acree-Van’t Hoff models with an average errors of <3.0 %. The highest and lowest xe value of OMT was estimated in neat P (2.70 × 10−3 at T = 318.2 K) and neat W (1.81 × 10−5 at T = 298.2 K), respectively. Moreover, HSP of OMT was found to be closed with that of neat P. The solubility of OMT was found to be increased significantly with an increase in temperature and P mass fraction in all (P + W) cosolvent compositions including neat P and neat W. The results of activity coefficients suggested higher molecular interactions in OMT-P combination compared with OMT-W combination. The results of thermodynamic studies indicated an endothermic and entropy-driven dissolution of OMT in all (P + W) cosolvent compositions including neat P and neat W.
Acknowledgments
The authors would like to extend their appreciation to the Deanship of Scientific Research at King Saud University for funding this work through the research group no. RG-1435-005.
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This study was funded by Deanship of Scientific Research under grant RG-1435-005.
Conflict of interest statement: The authors report no conflict of interest associated with this manuscript.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Original Papers
- Solubility determination, computational modeling, Hansen solubility parameters and apparent thermodynamic analysis of brigatinib in (ethanol + water) mixtures
- Solubilization, Hansen solubility parameters and apparent thermodynamic parameters of Osimertinib in (propylene glycol + water) cosolvent mixtures
- Astaxanthin–garlic oil nanoemulsions preparation using spontaneous microemulsification technique: optimization and their physico–chemical properties
- In-situ stabilization of silver nanoparticles in polymer hydrogels for enhanced catalytic reduction of macro and micro pollutants
- Kinetic and equilibrium study of (poly amido amine) PAMAM dendrimers for the removal of chromium from tannery wastewater
- Experimental modeling, optimization and comparison of coagulants for removal of metallic pollutants from wastewater
- ZnO, CuO and Fe2O3 green synthesis for the adsorptive removal of direct golden yellow dye adsorption: kinetics, equilibrium and thermodynamics studies
- Kinetic and thermodynamic studies for evaluation of adsorption capacity of fungal dead biomass for direct dye
Artikel in diesem Heft
- Frontmatter
- Original Papers
- Solubility determination, computational modeling, Hansen solubility parameters and apparent thermodynamic analysis of brigatinib in (ethanol + water) mixtures
- Solubilization, Hansen solubility parameters and apparent thermodynamic parameters of Osimertinib in (propylene glycol + water) cosolvent mixtures
- Astaxanthin–garlic oil nanoemulsions preparation using spontaneous microemulsification technique: optimization and their physico–chemical properties
- In-situ stabilization of silver nanoparticles in polymer hydrogels for enhanced catalytic reduction of macro and micro pollutants
- Kinetic and equilibrium study of (poly amido amine) PAMAM dendrimers for the removal of chromium from tannery wastewater
- Experimental modeling, optimization and comparison of coagulants for removal of metallic pollutants from wastewater
- ZnO, CuO and Fe2O3 green synthesis for the adsorptive removal of direct golden yellow dye adsorption: kinetics, equilibrium and thermodynamics studies
- Kinetic and thermodynamic studies for evaluation of adsorption capacity of fungal dead biomass for direct dye
