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Genetic background of febrile seizures

  • Amene Saghazadeh , Mario Mastrangelo und Nima Rezaei EMAIL logo
Veröffentlicht/Copyright: 8. Januar 2014
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Abstract

Febrile seizures (FSs) occur in children older than 1 month and without prior afebrile seizures in the absence of a central nervous system infection or acute electrolyte imbalance. Their pathogenesis is multifactorial. The most relevant familial studies evidence an occurrence rate ranging from 10% to 46% and median recurrence rate of 36% in children with positive familial history for FS. The main twin studies demonstrated a higher concordance rate in monozygotic twins with FS than in dizygotic ones. Linkage studies have proposed 11 chromosomal locations responsible to FS attributed to FEB1 to FEB11. Population-based association studies have shown at least one positive association for 14 of 41 investigated genes with FS. The proinflammatory cytokine interleukin 1β (IL-1β) was the most investigated and also gene associated with susceptibility to FS. A possible role in the overlapping of epilepsy and FS was found for 16 of 36 investigated genes. SCN1A, IL-1β, CHRNA4, and GABRG2 were the most commonly involved genes in this context. The genetic background of FS involves the regulation of different processes, including individual and familial susceptibility, modulation of immune response, and neuronal excitability and interactions with exogenous agents such as viruses.


Corresponding author: Nima Rezaei, Molecular Immunology Research Center and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, e-mail: ; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Dr. Qarib St, Tehran 14194, Iran; and Department of Infection and Immunity, School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield, UK

We thank Dr. Masih Shafiei for his assistance in managing the reference list and Mr. Davoud Zand for his valuable technical contribution in preparing tables. This study was supported by a grant from Tehran University of Medical Sciences.

References

Annegers, J.F., Hauser, W.A., Shirts, S.B., and Kurland, L.T. (1987). Factors prognostic of unprovoked seizures after febrile convulsions. N. Engl. J. Med. 316, 493–498.10.1056/NEJM198702263160901Suche in Google Scholar

Annegers, J.F., Blakley, S.A., Allen Hauser, W., and Kurland, L.T. (1990). Recurrence of febrile convulsions in a population-based cohort. Epilepsy Res. 5, 209–216.10.1016/0920-1211(90)90040-3Suche in Google Scholar

Audenaert, D., Schwartz, E., Claeys, K.G., Claes, L., Deprez, L., Suls, A., Van Dyck, T., Lagae, L., Van Broeckhoven, C., Macdonald, R.L., et al. (2006). A novel GABRG2 mutation associated with febrile seizures. Neurology 67, 687–690.10.1212/01.wnl.0000230145.73496.a2Suche in Google Scholar PubMed

Balan, S., Vellichirammal, N.N., Banerjee, M., and Radhakrishnan, K. (2012). Failure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis. Epilepsy Res. 101, 288–292.10.1016/j.eplepsyres.2012.04.009Suche in Google Scholar PubMed

Baulac, S., Gourfinkel-An, I., Picard, F., Rosenberg-Bourgin, M., Prud’homme, J.-F., Baulac, M., Brice, A., and LeGuern, E. (1999). A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21–q33. Am. J. Hum. Genet. 65, 1078–1085.10.1086/302593Suche in Google Scholar PubMed PubMed Central

Baulac, S., Huberfeld, G., Gourfinkel-An, I., Mitropoulou, G., Beranger, A., Prud’homme, J.-F., Baulac, M., Brice, A., Bruzzone, R., and Leguern, E. (2001). First genetic evidence of GABAA receptor dysfunction in epilepsy: a mutation in the γ2-subunit gene. Nature Genet. 28, 46–48.10.1038/ng0501-46Suche in Google Scholar PubMed

Berg, A.T., Shinnar, S., Levy, S.R., and Testa, F.M. (1999). Childhood-onset epilepsy with and without preceding febrile seizures. Neurology 53, 1742.10.1212/WNL.53.8.1742Suche in Google Scholar

Berkovic, S.F., Howell, R.A., Hay, D.A., and Hopper, J.L. (1998). Epilepsies in twins: genetics of the major epilepsy syndromes. Ann. Neurol. 43, 435–445.10.1002/ana.410430405Suche in Google Scholar PubMed

Bertolani, M., Portolani, M., Marotti, F., Sabbattini, A., Chiossi, C., Bandieri, M., and Cavazzuti, G.B. (1996). A study of childhood febrile convulsions with particular reference to HHV-6 infection: pathogenic considerations. Childs Nerv. Syst. 12, 534–539.10.1007/BF00261607Suche in Google Scholar PubMed

Blair, M.A., Ma, S., Abou-Khalil, B., and Hedera, P. (2007). Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients. Eur. J. Neurol. 14, 424–427.10.1111/j.1468-1331.2007.01702.xSuche in Google Scholar PubMed

Bovo, G., Diani, E., Bisulli, F., Di Bonaventura, C., Striano, P., Gambardella, A., Ferlazzo, E., Egeo, G., Mecarelli, O., Elia, M., et al. (2008). Analysis of LGI1 promoter sequence, PDYN and GABBR1 polymorphisms in sporadic and familial lateral temporal lobe epilepsy. Neurosci. Lett. 436, 23–26.10.1016/j.neulet.2008.02.045Suche in Google Scholar

Bragatti, J.A., Schenkel, L.C., Torres, C.M., Manfro, G.G., Blaya, C., Souza, A.C.d., Souza, D.O., Saraiva-Pereira, M.L., Jardim, L.B., Leistner-Segal, S., et al. (2010). No major clinical impact of Val66Met BDNF gene polymorphism on temporal lobe epilepsy. Epilepsy Res. 88, 108–111.10.1016/j.eplepsyres.2009.10.003Suche in Google Scholar

Buono, R.J., Ferraro, T.N., O’Connor, M.J., Sperling, M.R., Ryan, S.G., Scattergood, T., Mulholland, N., Gilmore, J., Lohoff, F.W., and Berrettini, W.H. (2001). Lack of association between an interleukin 1 beta (IL-1β) gene variation and refractory temporal lobe epilepsy. Epilepsia 42, 782–784.10.1046/j.1528-1157.2001.42900.xSuche in Google Scholar

Cavalleri, G.L., Lynch, J.M., Depondt, C., Burley, M.-W., Wood, N.W., Sisodiya, S.M., and Goldstein, D.B. (2005). Failure to replicate previously reported genetic associations with sporadic temporal lobe epilepsy: where to from here? Brain 128, 1832–1840.10.1093/brain/awh524Suche in Google Scholar

Chioza, B., Goodwin, H., Blower, J., McCormick, D., Nashef, L., Asherson, P., and Makoff, A.J. (2000). Failure to replicate association between the gene for the neuronal nicotinic acetylcholine receptor α4 subunit (CHRNA4) and IGE. Am. J. Med. Genet. 96, 814–816.10.1002/1096-8628(20001204)96:6<814::AID-AJMG24>3.0.CO;2-MSuche in Google Scholar

Chioza, B., Osei-Lah, A., Wilkie, H., Nashef, L., McCormick, D., Asherson, P., and Makoff, A.J. (2002). Suggestive evidence for association of two potassium channel genes with different idiopathic generalised epilepsy syndromes. Epilepsy Res. 52, 107–116.10.1016/S0920-1211(02)00195-XSuche in Google Scholar

Chiu, S.S., Tse, C.Y.C., Lau, Y.L., and Peiris, M. (2001). Influenza A infection is an important cause of febrile seizures. Pediatrics 108, e63.10.1542/peds.108.4.e63Suche in Google Scholar

Cho, Y., Motamedi, G.K., Laufenberg, I., Sohn, S.I., Lim, J.G., Lee, H., Yi, S.D., Lee, J.H., Kim, D.K., Reba, R., et al. (2003). A Korean kindred with autosomal dominant nocturnal frontal lobe epilepsy and mental retardation. Arch. Neurol. 60, 1625–1632.10.1001/archneur.60.11.1625Suche in Google Scholar

Cho, S.M., Kim, Y.H., Chung, S.Y., Lee, I.G., Whang, K.T., Lee, B.C., and Lee, K.H. (2005). Single nucleotide polymorphisms of GABRG2 in febrile seizures and GEFS+. J. Korean Child Neurol. Soc. 13, 144–151.Suche in Google Scholar

Chou, I.C., Tsai, F.J., Huang, C.C., Lin, C.C., and Tsai, C.H. (2002). The voltage-gated potassium channel KCNQ2 in Taiwanese children with febrile convulsions. Neuroreport 13, 1971–1973.10.1097/00001756-200210280-00028Suche in Google Scholar

Chou, I.C., Lee, C.-C., Huang, C.-C., Wu, J.-Y., Tsai, J.J.P., Tsai, C.-H., and Tsai, F.-J. (2003a). Association of the neuronal nicotinic acetylcholine receptor subunit α4 polymorphisms with febrile convulsions. Epilepsia 44, 1089–1093.10.1046/j.1528-1157.2003.t01-1-44702.xSuche in Google Scholar

Chou, I.C., Peng, C.T., Huang, C.C., Tsai, J.J., Tsai, F.J., and Tsai, C.H. (2003b). Association analysis of γ2 subunit of γ-aminobutyric acid type A receptor polymorphisms with febrile seizures. Pediatr. Res. 54, 26–29.10.1203/01.PDR.0000069696.96041.34Suche in Google Scholar

Chou, I.C., Peng, C.-T., Tsai, F.-J., Huang, C.-C., Shi, Y.-R., and Tsai, C.-H. (2003c). The lack of association between febrile convulsions and polymorphisms in SCN1A. Epilepsy Res. 54, 53–57.10.1016/S0920-1211(03)00043-3Suche in Google Scholar

Chou, I.C., Tsai, C.H., Hsieh, Y.Y., Peng, C.T., and Tsai, F.J. (2003d). Association between polymorphism of interleukin-1β-511 promoter and susceptibility to febrile convulsions in Taiwanese children. Acta Paediatr. 92, 1356.10.1111/j.1651-2227.2003.tb00513.xSuche in Google Scholar

Chou, I.C., Tsai, C.-H., Lee, C.-C., Lin, S.-S., and Tsai, F.-J. (2004). Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in febrile seizures. Epilepsy Res. 60, 27–29.10.1016/j.eplepsyres.2004.05.001Suche in Google Scholar PubMed

Chou, I.C., Lee, C.-C., Tsai, C.-H., Tsai, Y., Wan, L., Hsu, Y.-A., Li, T.C., and Tsai, F.J. (2007). Association of GABRG2 polymorphisms with idiopathic generalized epilepsy. Pediatr. Neurol. 36, 40–44.10.1016/j.pediatrneurol.2006.09.011Suche in Google Scholar PubMed

Chou, I.C., Lin, W.-D., Wang, C.-H., Tsai, C.-H., Li, T.-C., and Tsai, F.-J. (2010). Interleukin (IL)-1β, IL-1 receptor antagonist, IL-6, IL-8, IL-10, and tumor necrosis factor α gene polymorphisms in patients with febrile seizures. J. Clin. Lab. Anal. 24, 154–159.10.1002/jcla.20374Suche in Google Scholar PubMed PubMed Central

Chung, S.Y., Park, Y.J., Kim, Y.H., Lee, I.G., Whang, K.T., Lee, J.S., Kim, H.S., Lee, K.H., and Yim, S.V. (2006). Interleukin-1beta promoter polymorphisms in febrile seizures and GEFS+. J. Korean Child Neurol. Soc. 14, 113–120.Suche in Google Scholar

Commission on Epidemiology and Prognosis, International League Against Epilepsy. (1993). Guidelines for epidemiologic studies on epilepsy. Epilepsia 34, 592–596.Suche in Google Scholar

Conti, B., Tabarean, I., Andrei, C., and Bartfai, T. (2004). Cytokines and fever. Front. Biosci. 9, 1433–1449.10.2741/1341Suche in Google Scholar PubMed

Corey, L.A., Berg, K., Pellock, J.M., Solaas, M.H., Nance, W.E., and DeLorenzo, R.J. (1991). The occurrence of epilepsy and febrile seizures in Virginian and Norwegian twins. Neurology 41, 1433.10.1212/WNL.41.9.1433Suche in Google Scholar

Cross, J.H. (2012). Fever and fever-related epilepsies. Epilepsia 53, 3–8.10.1111/j.1528-1167.2012.03608.xSuche in Google Scholar PubMed

Dai, X.-H., Chen, W.-W., Wang, X., Zhu, Q.-H., Li, C., Li, L., Liu, M.G., Wang, Q.K., and Liu, J.Y. (2008). A novel genetic locus for familial febrile seizures and epilepsy on chromosome 3q26.2–q26.33. Hum. Genet. 124, 423–429.10.1007/s00439-008-0566-9Suche in Google Scholar PubMed

Dibbens, L.M., Reid, C.A., Hodgson, B., Thomas, E.A., Phillips, A.M., Gazina, E., Cromer, B.A., Clarke, A.L., Baram, T.Z., Scheffer, I.E., et al. (2010). Augmented currents of an HCN2 variant in patients with febrile seizure syndromes. Ann. Neurol. 67, 542–546.10.1002/ana.21909Suche in Google Scholar PubMed PubMed Central

Dubé, C., Vezzani, A., Behrens, M., Bartfai, T., and Baram, T.Z. (2005). Interleukin-1β contributes to the generation of experimental febrile seizures. Ann. Neurol. 57, 152–155.10.1002/ana.20358Suche in Google Scholar PubMed PubMed Central

el-Radhi, A.S. and Banajeh, S. (1989). Effect of fever on recurrence rate of febrile convulsions. Arch. Dis. Child. 64, 869–870.10.1136/adc.64.6.869Suche in Google Scholar PubMed PubMed Central

Escayg, A., Heils, A., MacDonald, B.T., Haug, K., Sander, T., and Meisler, M.H. (2001). A novel SCN1A mutation associated with generalized epilepsy with febrile seizures plus – and prevalence of variants in patients with epilepsy. Am. J. Hum. Genet. 68, 866–873.10.1086/319524Suche in Google Scholar PubMed PubMed Central

Fetveit, A. (2008). Assessment of febrile seizures in children. Eur. J. Pediatr. 167, 17–27.10.1007/s00431-007-0577-xSuche in Google Scholar PubMed

Fu, Y.-H., Lv, R.-J., Jin, L.-R., Lu, Q., Shao, X.-Q., He, J.-S., Wu, L.W., Zhang, L.S., and Hu, H.G. (2010). Association of apolipoprotein E polymorphisms with temporal lobe epilepsy in a Chinese Han population. Epilepsy Res. 91, 253–259.10.1016/j.eplepsyres.2010.07.020Suche in Google Scholar PubMed

Gao, B., Hu, M.-s., and Zhang, L. (2007). A study on the association of polymorphism of IL-10 with febrile convulsion. Chin. J. Birth Health Hered. 3, 009.Suche in Google Scholar

Gao, M.-m., Qin, B., Shi, Y.-w., Yu, M.-j., Deng, W.-y., and Liao, W.-p. (2010). Association between polymorphism of exon 7-21C> T in SCN1A and generalized epilepsy with febrile seizures plus patients. J. Trop. Med. 5, 027.Suche in Google Scholar

Giray, Ö., Ülgenalp, A., Bora, E., Uran, N., Yilmaz, E., Ünalp, A., and Erçal, D. (2008). Role of apolipoprotein E in febrile convulsion. Pediatr. Neurol. 39, 241–244.10.1016/j.pediatrneurol.2008.06.014Suche in Google Scholar PubMed

Gitaí, L., de Almeida, D., Born, J., Gameleira, F., de Andrade, T., Machado, L., and Gitaí, D.L. (2012). Lack of association between rs211037 of the GABRG2 gene and juvenile myoclonic epilepsy in Brazilian population. Neurol. India 60, 585.10.4103/0028-3886.105191Suche in Google Scholar PubMed

Haider, M.Z., Habeeb, Y., Al-Nakkas, E., Al-Anzi, H., Zaki, M., Al-Tawari, A., and Al-Bloushi, M. (2005). Lack of an association between candidate gene loci and idiopathic generalized epilepsy in Kuwaiti Arab children. J. Biomed. Sci. 12, 815–818.10.1007/s11373-005-9009-ySuche in Google Scholar PubMed

Hall, C.B., Long, C.E., Schnabel, K.C., Caserta, M.T., McIntyre, K.M., Costanzo, M.A., Knott, A., Dewhurst, S., Insel, R.A., and Epstein, L.G. (1994). Human herpes virus-6 infection in children: a prospective study of complications and reactivation. N. Engl. J. Med. 331, 432–438.10.1056/NEJM199408183310703Suche in Google Scholar PubMed

Hamati-Haddad, A. and Abou-Khalil, B. (1998). Epilepsy diagnosis and localization in patients with antecedent childhood febrile convulsions. Neurology 50, 917–922.10.1212/WNL.50.4.917Suche in Google Scholar

Haspolat, S., Mihçi, E., Coşkun, M., Gümüslü, S., Özbenm, T., and Yegin, O. (2002). Interleukin-1β, tumor necrosis factor-α, and nitrite levels in febrile seizures. J. Child Neurol. 17, 749–751.10.1177/08830738020170101501Suche in Google Scholar

Haspolat, ş., Baysal, Y., Duman, Ö., Coşkun, M., Tosun, Ö., and Yein, O. (2005). Interleukin-1α, interleukin-1β, and interleukin-1Ra polymorphisms in febrile seizures. J. Child Neurol. 20, 565–568.10.1177/08830738050200070401Suche in Google Scholar

Haug, K., Hallmann, K., Rebstock, J., Dullinger, J., Muth, S., Haverkamp, F., Pfeiffer, H., Rau, B., Elger, C.E., Propping, P., et al. (2001). The voltage-gated sodium channel gene SCN2A and idiopathic generalized epilepsy. Epilepsy Res. 47, 243–246.10.1016/S0920-1211(01)00312-6Suche in Google Scholar

Hedera, P., Ma, S., Blair, M.A., Taylor, K.A., Hamati, A., Bradford, Y., Abou-Khalil, B., and Haines, J.L. (2006). Identification of a novel locus for febrile seizures and epilepsy on chromosome 21q22. Epilepsia 47, 1622–1628.10.1111/j.1528-1167.2006.00637.xSuche in Google Scholar PubMed

Heida, J.G. and Pittman, Q.J. (2005). Causal links between brain cytokines and experimental febrile convulsions in the rat. Epilepsia 46, 1906–1913.10.1111/j.1528-1167.2005.00294.xSuche in Google Scholar PubMed

Heida, J.G., Moshé, S.L., and Pittman, Q.J. (2009). The role of interleukin-1β in febrile seizures. Brain Dev. 31, 388–393.10.1016/j.braindev.2008.11.013Suche in Google Scholar PubMed PubMed Central

Hesdorffer, D.C., Shinnar, S., Lewis, D.V., Moshé, S.L., Nordli, D.R., Pellock, J.M., MacFall, J., Shinnar, R.C., Masur, D., Frank, L.M., et al. (2012). Design and phenomenology of the FEBSTAT study. Epilepsia 53, 1471–1480.10.1111/j.1528-1167.2012.03567.xSuche in Google Scholar PubMed PubMed Central

Heuser, K., Hoddevik, E.H., Taubøll, E., Gjerstad, L., Indahl, U., Kaczmarek, L., Berg, P.R., Lien, S., Nagelhus, E.A., and Ottersen, O.P. (2010a). Temporal Lobe epilepsy and matrix metalloproteinase 9: a tempting relation but negative genetic association. Seizure 19, 335–338.10.1016/j.seizure.2010.05.003Suche in Google Scholar PubMed

Heuser, K., Nagelhus, E.A., Taubøll, E., Indahl, U., Berg, P.R., Lien, S., Nakken, S., Gjerstad, L., and Ottersen, O.P. (2010b). Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. Epilepsy Res. 88, 55–64.10.1016/j.eplepsyres.2009.09.023Suche in Google Scholar PubMed

Hirose, S., Iwata, H., Akiyoshi, H., Kobayashi, K., Ito, M., Wada, K., Kaneko, S., and Mitsudome, A. (1999). A novel mutation of CHRNA4 responsible for autosomal dominant nocturnal frontal lobe epilepsy. Neurology 53, 1749–1753.10.1212/WNL.53.8.1749Suche in Google Scholar

Hirose, S., Scheffer, I.E., Marini, C., De Jonghe, P., Andermann, E., Goldman, A.M., Kauffman, M., Tan, N.C., Lowenstein, D.H., Sisodiya, S.M., et al. (2013). SCN1A testing for epilepsy: application in clinical practice. Epilepsia 54, 946–952.10.1111/epi.12168Suche in Google Scholar

Huang, C.-C., Wang, S.-T., Chang, Y.-C., Huang, M.-C., Chi, Y.-C., and Tsai, J.-J. (1999). Risk factors for a first febrile convulsion in children: a population study in Southern Taiwan. Epilepsia 40, 719–725.10.1111/j.1528-1157.1999.tb00769.xSuche in Google Scholar

Ishizaki, Y., Kira, R., Fukuda, M., Torisu, H., Sakai, Y., Sanefuji, M., Yukaya, N., and Hara, T. (2009). Interleukin-10 is associated with resistance to febrile seizures: genetic association and experimental animal studies. Epilepsia 50, 761–767.10.1111/j.1528-1167.2008.01861.xSuche in Google Scholar

Jamali, S., Salzmann, A., Perroud, N., Ponsole-Lenfant, M., Cillario, J., Roll, P., Roeckel-Trevisiol, N., Crespel, A., Balzar, J., Schlachter, K., et al. (2010). Functional variant in complement C3 gene promoter and genetic susceptibility to temporal lobe epilepsy and febrile seizures. PloS One 5, e12740.10.1371/journal.pone.0012740Suche in Google Scholar

Jasper, H.H., Noebels, J.L., Noebels, J., Avoli, M., Rogawski, M., and Olsen, R. (2012). Jasper’s Basic Mechanisms of the Epilepsies (Oxford University Press).10.1093/med/9780199746545.001.0001Suche in Google Scholar

Jin, L., Jia, Y., Zhang, B., Xu, Q., Fan, Y., Wu, L., Shen, Y. (2003). Association analysis of a polymorphism of interleukin 1β (IL-1β) gene with temporal lobe epilepsy in a Chinese population. Epilepsia 44, 1306–1309.10.1046/j.1528-1157.2003.11003.xSuche in Google Scholar

Johnson, E.W., Dubovsky, J., Rich, S.S., O’Donovan, C.A., Orr, H.T., Anderson, V.E., Gil-Nagel, A., Ahmann, P., Dokken, C.G., Schneider, D.T., et al. (1998). Evidence for a novel gene for familial febrile convulsions, FEB2, linked to chromosome 19p in an extended family from the Midwest. Hum. Mol. Gen. 7, 63–67.10.1093/hmg/7.1.63Suche in Google Scholar

Kananura, C., Haug, K., Sander, T., Runge, U., Gu, W., Hallmann, K., Rebstock, J., Heils, A., and Steinlein, O.K. (2002). A splice-site mutation in GABRG2 associated with childhood absence epilepsy and febrile convulsions. Arch. Neurol. 59, 1137–1141.10.1001/archneur.59.7.1137Suche in Google Scholar

Kanemoto, K., Kawasaki, J., Miyamoto, T., Obayashi, H., and Nishimura, M. (2000). Interleukin (IL)-1β, IL-1α, and IL-1 receptor antagonist gene polymorphisms in patients with temporal lobe epilepsy. Ann. Neurol. 47, 571–574.10.1002/1531-8249(200005)47:5<571::AID-ANA3>3.0.CO;2-ASuche in Google Scholar

Kanemoto, K., Kawasaki, J., Tarao, Y., Kumaki, T., Oshima, T., Kaji, R., and Nishimura, M. (2003a). Association of partial epilepsy with brain-derived neurotrophic factor (BDNF) gene polymorphisms. Epilepsy Res. 53, 255–258.10.1016/S0920-1211(03)00032-9Suche in Google Scholar

Kanemoto, K., Kawasaki, J., Yuasa, S., Kumaki, T., Tomohiro, O., Kaji, R., and Nishimura, M. (2003b). Increased frequency of interleukin-1β-511T allele in patients with temporal lobe epilepsy, hippocampal sclerosis, and prolonged febrile convulsion. Epilepsia 44, 796–799.10.1046/j.1528-1157.2003.43302.xSuche in Google Scholar

Kawada, J.-i., Kimura, H., Ito, Y., Hara, S., Iriyama, M., Yoshikawa, T., and Morishima, T. (2003). Systemic cytokine responses in patients with influenza-associated encephalopathy. J. Infect. Dis. 188, 690–698.10.1086/377101Suche in Google Scholar

Khoshdel, A., Kheiri, S., Habibian, R., Nozari, A., and Baradaran, A. (2012). Lack of association between TNF-α gene polymorphisms at position-308 A,-850T and risk of simple febrile convulsion in pediatric patients. Adv. Biomed. Res. 1, 85.10.4103/2277-9175.105167Suche in Google Scholar

Kim, S.E., Kim, H.G., Kim, Y.H., Choi, B.J., Hwang, H.S., Bin, J.H., Chung, S.Y., and Lee, I.G. (2008). Brain-derived neurotrophic factor (BDNF) SNP 6265 polymorphisms in febrile seizure and GEFS+. J. Korean Child Neurol. Soc. 16, 114–120.Suche in Google Scholar

Kim, Y.O., Kim, M.-K., Nam, T.-S., Jang, S.Y., Park, K.W., Kim, E.Y., Rho, Y.I., and Woo, Y.J. (2012). Mutation screening of the γ-aminobutyric acid type-A receptor subunit γ2 gene in Korean patients with childhood absence epilepsy. J. Clin. Neurol. 8, 271–275.10.3988/jcn.2012.8.4.271Suche in Google Scholar

Kinirons, P., Cavalleri, G.L., Shahwan, A., Wood, N.W., Goldstein, D.B., Sisodiya, S.M., Delanty N., and Doherty, C.P. (2006). Examining the role of common genetic variation in the γ2 subunit of the GABAA receptor in epilepsy using tagging SNPs. Epilepsy Res. 70, 229–238.10.1016/j.eplepsyres.2006.05.009Suche in Google Scholar

Kira, R., Torisu, H., Takemoto, M., Nomura, A., Sakai, Y., Sanefuji, M., Sakamoto, K., Matsumoto, S., Gondo, K., and Hara, T. (2005). Genetic susceptibility to simple febrile seizures: interleukin-1β promoter polymorphisms are associated with sporadic cases. Neurosci. Lett. 384, 239–244.10.1016/j.neulet.2005.04.097Suche in Google Scholar

Kira, R., Ishizaki, Y., Torisu, H., Sanefuji, M., Takemoto, M., Sakamoto, K., Matsumoto, S., Yamaguchi, Y., Yukaya, N., Sakai, Y., et al. (2010). Genetic susceptibility to febrile seizures: case-control association studies. Brain Dev. 32, 57–63.10.1016/j.braindev.2009.09.018Suche in Google Scholar

Kjeldsen, M.J., Kyvik, K.O., Friis, M.L., and Christensen, K. (2002). Genetic and environmental factors in febrile seizures: a Danish population-based twin study. Epilepsy Res. 51, 167–177.10.1016/S0920-1211(02)00121-3Suche in Google Scholar

Kjeldsen, M.J., Corey, L.A., Solaas, M.H., Friis, M.L., Harris, J.R., Kyvik, K.O., Christensen, K., and Pellock, J.M. (2005). Genetic factors in seizures: a population-based study of 47,626 US, Norwegian and Danish twin pairs. Twin Res. Hum. Genet. 8, 138–147.10.1375/twin.8.2.138Suche in Google Scholar

Kluger, M.J. (1991). Fever: role of pyrogens and cryogens. Physiol. Rev. 71, 93–127.10.1152/physrev.1991.71.1.93Suche in Google Scholar

Knudsen, F.U. (1985). Recurrence risk after first febrile seizure and effect of short term diazepam prophylaxis. Arch. Dis. Child. 60, 1045–1049.10.1136/adc.60.11.1045Suche in Google Scholar

Kumari, R., Lakhan, R., Kalita, J., Misra, U.K., and Mittal, B. (2010). Association of α subunit of GABAA receptor subtype gene polymorphisms with epilepsy susceptibility and drug resistance in north Indian population. Seizure 19, 237–241.10.1016/j.seizure.2010.02.009Suche in Google Scholar

Lakhan, R., Kumari, R., Misra, U.K., Kalita, J., Pradhan, S., and Mittal, B. (2009). Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population. Br. J. Clin. Pharmacol. 68, 214–220.10.1111/j.1365-2125.2009.03437.xSuche in Google Scholar

Le Gal, F., Salzmann, A., Crespel, A., and Malafosse, A. (2011). Replication of association between a SCN1A splice variant and febrile seizures. Epilepsia 52, e135–e138.Suche in Google Scholar

Lee, W.L., Biervert, C., Hallmann, K., Tay, A., Dean, J.C., and Steinlein, O.K. (2000). A KCNQ2 splice site mutation causing benign neonatal convulsions in a Scottish family. Neuropediatrics 31, 9–12.10.1055/s-2000-15290Suche in Google Scholar

Lee, C.-C., Chou, I.C., Tsai, C.-H., Wan, L., Shu, Y.-A., Tsai, Y., Li, T.C., and Tsai, F.J. (2007). Association of idiopathic generalized epilepsy with polymorphisms in the neuronal nicotinic acetylcholine receptor subunits. J. Clin. Lab. Anal. 21, 67–70.10.1002/jcla.20155Suche in Google Scholar

Leniger, T., Kananura, C., Hufnagel, A., Bertrand, S., Bertrand, D., and Steinlein, O.K. (2003). A new Chrna4 mutation with low penetrance in nocturnal frontal lobe epilepsy. Epilepsia 44, 981–985.10.1046/j.1528-1157.2003.61102.xSuche in Google Scholar

Lin, L.C., Lin, H.S., and Yang, R.C. (2007). Neuropeptide Y gene polymorphism and plasma neuropeptide Y level in febrile seizure patients in Taiwan. Kaohsiung J. Med. Sci. 23, 560–565.10.1016/S1607-551X(08)70003-2Suche in Google Scholar

Lohoff, F.W., Ferraro, T.N., Dahl, J.P., Hildebrandt, M.A., Scattergood, T.M., O’Connor, M.J., Sperling, M.R., Dlugos, D.J., Berrettini, W.H., and Buono RJ. (2005). Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy. Epilepsy Res. 66, 59–62.10.1016/j.eplepsyres.2005.06.005Suche in Google Scholar

Lu, J., Chen, Y., Zhang, Y., Pan, H., Wu, H., Xu, K., Liu, X., Jiang, Y., Bao, X., Ding, K., et al. (2002). Mutation screen of the GABAA receptor γ2 subunit gene in Chinese patients with childhood absence epilepsy. Neurosci. Lett. 332, 75–78.10.1016/S0304-3940(02)00805-4Suche in Google Scholar

Lu, H.-y., Huang, S.-m., Zhang, A.-h., Zheng, G., and Huang, Y.-j. (2009). Association of IL-1α-889C/T polymorphism with the risk of pediatric epilepsy. Acta Univ. Med. Nanjing (Natural Science) 8, 023.Suche in Google Scholar

Ma, Y.N., Hao, L., Niu, S.L., Xu, Y.F., Zhang, Y., Pei, P., Bu, D.F., and Qi, Y. (2004). Five single nucleotide polymorphisms of casein kinase I γ2 gene in children with familial febrile convulsions. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chin. J. Med. Genet. 21, 347–350.Suche in Google Scholar

Ma, S., Abou-Khalil, B., Sutcliffe, J.S., Haines, J.L., and Hedera, P. (2005a). The GABBR1 locus and the G1465A variant is not associated with temporal lobe epilepsy preceded by febrile seizures. BMC Med. Genet. 6, 13.10.1186/1471-2350-6-13Suche in Google Scholar

Ma, Y., Chen, Z., Zou, L., Zhang, Y., Niu, S., Xu, Y., Pei, P., Bu, D.F., and Qi, Y. (2005b). Association between familial febrile convulsions and HCN2 gene. Zhonghua yi xue za zhi 85, 663–666.Suche in Google Scholar

Mahoney, K., Buckley, D., Alam, M., Penney, S., Young, T.-L., Parfrey, P., and Moore, S.J. (2012). High incidence of pediatric idiopathic epilepsy is associated with familial and autosomal dominant disease in Eastern Newfoundland. Epilepsy Res. 98, 140–147.10.1016/j.eplepsyres.2011.09.003Suche in Google Scholar

Makoff, A., Lai, T., Barratt, C., Valentin, A., Moran, N., Asherson, P., and Nashef, L. (2010). High-density SNP screen of sodium channel genes by haplotype tagging and DNA pooling for association with idiopathic generalized epilepsy. Epilepsia 51, 694–698.10.1111/j.1528-1167.2009.02473.xSuche in Google Scholar

Mantegazza, M., Gambardella, A., Rusconi, R., Schiavon, E., Annesi, F., Cassulini, R.R., Labate, A., Carrideo, S., Chifari, R., Canevini, M.P., et al. (2005). Identification of an Nav1.1 sodium channel (SCN1A) loss-of-function mutation associated with familial simple febrile seizures. Proc. Natl. Acad. Sci. USA 102, 18177–18182.10.1073/pnas.0506818102Suche in Google Scholar

Matsuo, M., Sasaki, K., Ichimaru, T., Nakazato, S., and Hamasaki, Y. (2006). Increased IL-1β production from dsRNA-stimulated leukocytes in febrile seizures. Pediatr. Neurol. 35, 102–106.10.1016/j.pediatrneurol.2005.12.005Suche in Google Scholar

Miller, L.L., Pellock, J.M., DeLorenzo, R.J., Meyer, J.M., and Corey, L.A. (1998). Univariate genetic analyses of epilepsy and seizures in a population-based twin study: the Virginia Twin Registry. Genet. Epidemiol. 15, 33–49.10.1002/(SICI)1098-2272(1998)15:1<33::AID-GEPI3>3.0.CO;2-5Suche in Google Scholar

Miller, L.L., Pellock, J.M., Boggs, J.G., DeLorenzo, R.J., Meyer, J.M., and Corey, L.A. (1999). Epilepsy and seizure occurrence in a population-based sample of Virginian twins and their families. Epilepsy Res. 34, 135–143.10.1016/S0920-1211(98)00113-2Suche in Google Scholar

Millichap, J.G. and Millichap, J.J. (2006). Role of viral infections in the etiology of febrile seizures. Pediatr. Neurol. 35, 165–172.10.1016/j.pediatrneurol.2006.06.004Suche in Google Scholar

Moulard, B., Chaigne, D., Mouthon, D., Buresi, C., Guipponi, M., and Malafosse, A. (1999). Identification of a new locus for generalized epilepsy with febrile seizures plus (GEFS+) on chromosome 2q24–q33. Am. J. Hum. Genet. 65, 1396–1400.10.1086/302621Suche in Google Scholar

Mulley, J., Heron, S., Scheffer, I., and Berkovic, S. (2004). Febrile convulsions and genetic susceptibility: role of the neuronal nicotinic acetylcholine receptor α4 subunit. Epilepsia 45, 561.10.1111/j.0013-9580.2004.62803.xSuche in Google Scholar

Nabbout, R., Prud’homme, J.F., Herman, A., Feingold, J., Brice, A., Dulac, O., and LeGuern, E. (2002). A locus for simple pure febrile seizures maps to chromosome 6q22–q24. Brain 125, 2668–2680.10.1093/brain/awf281Suche in Google Scholar

Nabbout, R., Baulac, S., Desguerre, I., Bahi-Buisson, N., Chiron, C., Ruberg, M., Dulac, O., and LeGuern, E. (2007). New locus for febrile seizures with absence epilepsy on 3p and a possible modifier gene on 18p. Neurology 68, 1374–1381.10.1212/01.wnl.0000260062.02829.e3Suche in Google Scholar

Nakayama, J., Hamano, K., Iwasaki, N., Nakahara, S., Horigome, Y., Saitoh, H., Aoki, T., Maki, T., Kikuchi, M., Migita, T., et al. (2000). Significant evidence for linkage of febrile seizures to chromosome 5q14–q15. Hum. Mol. Gen. 9, 87–91.10.1093/hmg/9.1.87Suche in Google Scholar

Nakayama, J., Yamamoto, N., Hamano, K., Iwasaki, N., Ohta, M., Nakahara, S., Horigome, Y., Nakahara, C., Noguchi, E., Shiono, J., et al. (2002). Failure to find evidence for association between voltage-gated sodium channel gene SCN2A variants and febrile seizures in humans. Neurosci. Lett. 329, 249–251.10.1016/S0304-3940(02)00651-1Suche in Google Scholar

Nakayama, J., Hamano, K., Iwasaki, N., Ohta, M., Nakahara, S., Matsui, A., and Arinami, T. (2003a). Mutation analysis of the leucine-rich, glioma inactivated 1 gene (LGI1) in Japanese febrile seizure patients. Neuropediatrics 34, 234–236.10.1055/s-2003-43255Suche in Google Scholar

Nakayama, J., Hamano, K., Noguchi, E., Horiuchi, Y., Iwasaki, N., Ohta, M., Nakahara, S., Naoi, T., Matsui, A., Arinami, T. (2003b). Failure to find causal mutations in the GABAA-receptor γ2 subunit (GABRG2) gene in Japanese febrile seizure patients. Neurosci. Lett. 343, 117–120.10.1016/S0304-3940(03)00338-0Suche in Google Scholar

Nakayama, J., Yamamoto, N., Hamano, K., Iwasaki, N., Ohta, M., Nakahara, S., Matsui, A., Noguchi, E., and Arinami, T. (2004). Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18. Neurology 63, 1803–1807.10.1212/01.WNL.0000144499.34164.E0Suche in Google Scholar PubMed

Neligan, A., Bell, G.S., Giavasi, C., Johnson, A.L., Goodridge, D.M., Shorvon, S.D., and Sander, J.W. (2012). Long-term risk of developing epilepsy after febrile seizures: a prospective cohort study. Neurology 78, 1166–1170.10.1212/WNL.0b013e31824f807aSuche in Google Scholar PubMed

Nelson, K.B. and Ellenberg, J.H. (1978). Prognosis in children with febrile seizures. Pediatrics 61, 720–727.10.1542/peds.61.5.720Suche in Google Scholar

Netea, M.G., Kullberg, B.J., and Van der Meer, J.W.M. (2000). Circulating cytokines as mediators of fever. Clin. Infect. Dis. 31, S178–S184.10.1086/317513Suche in Google Scholar PubMed

Neubauer, B.A., Waldegger, S., Heinzinger, J., Hahn, A., Kurlemann, G., Fiedler, B., Eberhard, F., Muhle, H., Stephani, U., Garkisch, S., et al. (2008). KCNQ2 and KCNQ3 mutations contribute to different idiopathic epilepsy syndromes. Neurology 71, 177–183.10.1212/01.wnl.0000317090.92185.ecSuche in Google Scholar

Nur, B.G., Kahramaner, Z., Duman, O., Dundar, N.O., Sallakcı, N., Yavuzer, U., and Haspolat, S. (2012). Interleukin-6 gene polymorphism in febrile seizures. Pediatr. Neurol. 46, 36–38.10.1016/j.pediatrneurol.2011.10.008Suche in Google Scholar

Nur, B.G., Sahinturk, D., Coskun, M., Duman, O., Yavuzer, U., and Haspolat, S. (2012). Single nucleotide polymorphism and production of IL-1β and IL-10 cytokines in febrile seizures. Neuropediatrics 43, 194–200.10.1055/s-0032-1323849Suche in Google Scholar

Offringa, M., Derksen-Lubsen, G., Bossuyt, P.M., and Lubsen, J. (1992). Seizure recurrence after a first febrile seizure: a multivariate approach. Dev. Med. Child Neurol. 34, 15–24.10.1111/j.1469-8749.1992.tb08559.xSuche in Google Scholar

Offringa, M., Bossuyt, P.M.M., Lubsen, J., Ellenberg, J.H., Nelson, K.B., Knudsen, F.U., Annegers, J.F., el-Radhi, A.S., Habbema, J.D., Derksen-Lubsen, G., et al. (1994). Risk factors for seizure recurrence in children with febrile seizures: a pooled analysis of individual patient data from five studies. J. Pediatr. 124, 574–584.10.1016/S0022-3476(05)83136-1Suche in Google Scholar

Ozkara, C., Uzan, M., Tanriverdi, T., Baykara, O., Ekinci, B., Yeni, N., Kafadar, A., and Buyru, N. (2006). Lack of association between IL-1β/α gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis. Seizure 15, 288–291.10.1016/j.seizure.2006.02.016Suche in Google Scholar

Peiffer, A., Thompson, J., Charlier, C., Otterud, B., Varvil, T., Pappas, C., Barnitz, C., Gruenthal, K., Kuhn, R., and Leppert, M. (1999). A locus for febrile seizures (FEB3) maps to chromosome 2q23–24. Ann. Neurol. 46, 671–678.10.1002/1531-8249(199910)46:4<671::AID-ANA20>3.0.CO;2-5Suche in Google Scholar

Peltola, J., Keränen, T., Rainesalo, S., and Hurme, M. (2001). Polymorphism of the interleukin-1 gene complex in localization-related epilepsy. Ann. Neurol. 50, 275–276.10.1002/ana.1108Suche in Google Scholar

Peng, C.-T., Chou, I.C., Li, C.-I., Hsu, Y.-A., Tsai, C.-H., and Tsai, F.-J. (2004). Association of the nicotinic receptor β2 subunit and febrile seizures. Pediatr. Neurol. 30, 186–189.10.1016/j.pediatrneurol.2003.08.001Suche in Google Scholar

Petrovski, S., Scheffer, I.E., Sisodiya, S.M., O’Brien, T.J., Berkovic, S.F., Consortium ObotE. (2009). Lack of replication of association between SCN1A SNP and febrile seizures. Neurology 73, 1928–1930.10.1212/WNL.0b013e3181c3fd6fSuche in Google Scholar

Poeck, H. and Ruland, J. (2012). From virus to inflammation: mechanisms of RIG-I-induced IL-1β production. Eur. J. Cell Biol. 91, 59–64.10.1016/j.ejcb.2011.01.013Suche in Google Scholar PubMed

Ponnala, S., Chaudhari, J.R., Jaleel, M.A., Bhiladvala, D., Kaipa, P.R., Das, U.N., and Hasan, Q. (2012). Role of MDR1 C3435T and GABRG2 C588T gene polymorphisms in seizure occurrence and MDR1 effect on anti-epileptic drug (phenytoin) absorption. Genet. Test. Mol. Biomark. 16, 550–557.10.1089/gtmb.2011.0225Suche in Google Scholar PubMed

Rozycka, A., Steinborn, B., and Trzeciak, W.H. (2009). The 1674+11C>T polymorphism of CHRNA4 is associated with juvenile myoclonic epilepsy. Seizure 18, 601–603.10.1016/j.seizure.2009.06.007Suche in Google Scholar PubMed

Sáenz, A, Galán, J., Caloustian, C., Lorenzo, F., Márquez, C., Rodríguez, N., Jiménez, M.D., Poza, J.J., Cobo, A.M., Grid, D., et al. (1999). Autosomal dominant nocturnal frontal lobe epilepsy in a Spanish family with a Ser252Phe mutation in the Chrna4 gene. Arch. Neurol. 56, 1004–1009.10.1001/archneur.56.8.1004Suche in Google Scholar PubMed

Salam, S., Rahman, H., and Karam, R. (2012). GABRG2 gene polymorphisms in Egyptian children with simple febrile seizures. Indian J. Pediatr. 79, 1–3.10.1007/s12098-011-0564-0Suche in Google Scholar PubMed

Salzmann, A., Guipponi, M., Lyons, P.J., Fricker, L.D., Sapio, M., Lambercy, C., Buresi, C., Ouled Amar Bencheikh, B., Lahjouji, F., Ouazzani, R., et al. (2012). Carboxypeptidase A6 gene (CPA6) mutations in a recessive familial form of febrile seizures and temporal lobe epilepsy and in sporadic temporal lobe epilepsy. Hum. Mutat. 33, 124–135.10.1002/humu.21613Suche in Google Scholar PubMed

Sargin, G., Gürses, C., Naci, Ç., Bebek, N., Baykan, B., Özbek, U., and Ayşen, G. (2008). BDNF gene polymorphism in patients with temporal lobe epilepsy. J. Neurol. Sci. (Turkish) 25, 220–225.Suche in Google Scholar

Scheffer, I.E. and Berkovic, S.F. (1997). Generalized epilepsy with febrile seizures plus: a genetic disorder with heterogeneous clinical phenotypes. Brain 120, 479–490.10.1093/brain/120.3.479Suche in Google Scholar PubMed

Scheffer, I.E., Zhang, Y.-H., Jansen, F.E., and Dibbens, L. (2009). Dravet syndrome or genetic (generalized) epilepsy with febrile seizures plus? Brain Dev. 31, 394–400.Suche in Google Scholar

Schlachter, K., Gruber-Sedlmayr, U., Stogmann, E., Lausecker, M., Hotzy, C., Balzar, J., Schuh, E., Baumgartner, C., Mueller, J.C., Illig, T., et al. (2009). A splice site variant in the sodium channel gene SCN1A confers risk of febrile seizures. Neurology 72, 974–978.10.1212/01.wnl.0000344401.02915.00Suche in Google Scholar PubMed

Serdaroğlu, G., Alpman, A., Tosun, A., Pehlıvan, S., Özkınay, F., Tekgül, H., and Gökben, S. (2009). Febrile seizures: interleukin 1β and interleukin-1 receptor antagonist polymorphisms. Pediatr. Neurol. 40, 113–116.10.1016/j.pediatrneurol.2008.10.004Suche in Google Scholar PubMed

Sfaihi, L., Maaloul, I., Kmiha, S., Aloulou, H., Chabchoub, I., Kamoun, T., and Hachicha, M. (2012). Febrile seizures: an epidemiological and outcome study of 482 cases. Childs Nerv. Syst. 28, 1779–1784.10.1007/s00381-012-1789-6Suche in Google Scholar PubMed

Singh, N.A., Pappas, C., Dahle, E.J., Claes, L.R.F., Pruess, T.H., De Jonghe, P., Thompson, J., Dixon, M., Gurnett, C., Peiffer, A., et al. (2009). A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndrome. PLoS Genet. 5, e1000649.10.1371/journal.pgen.1000649Suche in Google Scholar

Steinlein, O., Sander, T., Stoodt, J., Kretz, R., Janz, D., and Propping, P. (1997). Possible association of a silent polymorphism in the neuronal nicotinic acetylcholine receptor subunit α4 with common idiopathic generalized epilepsies. Am. J. Med. Genet. 74, 445–449.10.1002/(SICI)1096-8628(19970725)74:4<445::AID-AJMG18>3.0.CO;2-ISuche in Google Scholar

Steinlein, O.K., Stoodt, J., Biervert, C., Janz, D., and Sander, T. (1999). The voltage gated potassium channel KCNQ2 and idiopathic generalized epilepsy. NeuroReport 10, 1163–1166.10.1097/00001756-199904260-00001Suche in Google Scholar

Sun, Y.-x., Xu, Z., and Ma, W.-n. (2005). The association study of calcyphosine (CAPS) gene with familiar febrile convulsions. Chin. J. Birth Health Hered. 7, 007.Suche in Google Scholar

Tan, E.H., Razak, S.A., Abdullah, J.M., and Mohamed Yusoff, A.A. (2012). De-novo mutations and genetic variation in the SCN1A gene in Malaysian patients with generalized epilepsy with febrile seizures plus (GEFS+). Epilepsy Res. 102, 210–215.10.1016/j.eplepsyres.2012.08.004Suche in Google Scholar

Tang, B., Sander, T., Craven, K.B., Hempelmann, A., and Escayg, A. (2008). Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy. Neurobiol. Dis. 29, 59–70.10.1016/j.nbd.2007.08.006Suche in Google Scholar

Tilgen, N., Pfeiffer, H., Cobilanschi, J., Rau, B., Horvath, S., Elger, C.E., Propping, P., and Heils A. (2002). Association analysis between the human interleukin 1β (-511) gene polymorphism and susceptibility to febrile convulsions. Neurosci. Lett. 334, 68–70.10.1016/S0304-3940(02)01069-8Suche in Google Scholar

Tiwari, P., Dwivedi, R., Mansoori, N., Alam, R., Chauhan, U.K., Tripathi, M., and Mukhopadhyay, A.K. (2012). Do gene polymorphism in IL-1β, TNF-α and IL-6 influence therapeutic response in patients with drug refractory epilepsy? Epilepsy Res. 101, 261–267.10.1016/j.eplepsyres.2012.04.013Suche in Google Scholar

Tsai, F.-J., Chou, I.C., Hsieh, Y.-Y., Lee, C.-C., Lin, C.-C., and Tsai, C.-H. (2002a). Interleukin-4 intron 3 polymorphism is not related to susceptibility to febrile seizures. Pediatr. Neurol. 27, 271–274.10.1016/S0887-8994(02)00434-4Suche in Google Scholar

Tsai, F., Hsieh, Y.-Y., Chang, C.-C., Lin, C.-C., and Tsai, C.H. (2002b). Polymorphisms for interleukin 1β exon 5 and interleukin 1 receptor antagonist in Taiwanese children with febrile convulsions. Arch. Pediatr. Adolesc. Med. 156, 545–548.10.1001/archpedi.156.6.545Suche in Google Scholar

Tsuboi, T. (1987). Genetic analysis of febrile convulsions: twin and family studies. Hum. Genet. 75, 7–14.10.1007/BF00273830Suche in Google Scholar

Tütüncüoğlu, S., Kütükçüler, N., Kepe, L., Çoker, C., Berdeli, A., and Tekgül, H. (2001). Proinflammatory cytokines, prostaglandins and zinc in febrile convulsions. Pediatr. Int. 43, 235–239.10.1046/j.1442-200x.2001.01389.xSuche in Google Scholar

Unalp, A., Bora, E., Cankaya, T., Giray Bozkaya, O., Ercal, D., Ozturk, A., and Ulgenalp, A. (2012). Lack of association of childhood partial epilepsy with brain derived neurotrophic factor gene. ScientificWorldJournal 2012, 414797.10.1100/2012/414797Suche in Google Scholar

van Esch, A., Steyerberg, E.W., van Duijn, C.M., Offringa, M., Derksen-Lubsen, G., van Steensel-Moll, H.A. (1998). Prediction of febrile seizures in siblings: a practical approach. Eur. J. Pediatr. 157, 340–344.10.1007/s004310050824Suche in Google Scholar

Virta, M., Hurme, M., and Helminen, M. (2002a). Increased frequency of interleukin-1β (-511) allele 2 in febrile seizures. Pediatr. Neurol. 26, 192–195.10.1016/S0887-8994(01)00380-0Suche in Google Scholar

Virta, M., Hurme, M., and Helminen, M. (2002b). Increased plasma levels of pro- and anti-inflammatory cytokines in patients with febrile seizures. Epilepsia 43, 920–923.10.1046/j.1528-1157.2002.02002.xSuche in Google Scholar PubMed

Viviani, B., Bartesaghi, S., Gardoni, F., Vezzani, A., Behrens, M.M., Bartfai, T., Binaglia, M., Corsini, E., Di Luca, M., Galli, C.L., et al. (2003). Interleukin-1β enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J. Neurosci. 23, 8692–8700.10.1523/JNEUROSCI.23-25-08692.2003Suche in Google Scholar

Volzone, A., Rizzo, R., Gagliano, A., Palmarino, M., Lucarelli, P., Arpino, C., and Curatolo, P. (2007). Lack of evidence for association between D2S124 and D2S111 polymorphisms of the SCN2A gene and idiopathic generalized epilepsy with generalized tonic-clonic seizures. J. Child Neurol. 22, 907–910.10.1177/0883073807304706Suche in Google Scholar PubMed

Wallace, R.H., Berkovic, S.F., Howell, R.A., Sutherland, G.R., and Mulley, J.C. (1996). Suggestion of a major gene for familial febrile convulsions mapping to 8q13–21. J. Med. Genet. 33, 308–312.10.1136/jmg.33.4.308Suche in Google Scholar PubMed PubMed Central

Wallace, R.H., Marini, C., Petrou, S., Harkin, L.A., Bowser, D.N., Panchal, R.G., Williams, D.A., Sutherland, G.R., Mulley, J.C., Scheffer, I.E., et al. (2001). Mutant GABAA receptor γ2-subunit in childhood absence epilepsy and febrile seizures. Nature Genet. 28, 49–52.10.1038/ng0501-49Suche in Google Scholar PubMed

Wang, S., Cheng, Q., Malik, S., and Yang, J. (2000). Interleukin-1β inhibits γ-aminobutyric acid type A (GABAA) receptor current in cultured hippocampal neurons. J. Pharmacol. Exp. Ther. 292, 497–504.Suche in Google Scholar

Wang, X., Xu, M., and Du, L. (2007). Association analysis of γ2 subunit of γ-aminobutyric acid (GABA) type A receptor and voltage-gated sodium channel type II α-polypeptide gene mutation in Southern Chinese children with febrile seizures. J. Child Neurol. 22, 714–719.10.1177/0883073807304002Suche in Google Scholar PubMed

Waruiru, C. and Appleton, R. (2004). Febrile seizures: an update. Arch. Dis. Child. 89, 751–756.10.1136/adc.2003.028449Suche in Google Scholar PubMed PubMed Central

Yeon, Y.H., Seung, S.J., Hwang, H.S., Kim, E., Kim, Y.H., Lee, I.G., et al. (2007). Single nucleotide polymorphisms of GABRG2 in idiopathic generalized epilepsies (IGEs). J. Korean Child Neurol. Soc. 15, 148–153.Suche in Google Scholar

Yinan, M., Yu, Q., Zhiyue, C., Jianjun, L., Lie, H., Liping, Z., Jianhui, Z., Fang, S., Dingfang, B., Qing, L., et al. (2004). Polymorphisms of casein kinase I γ2 gene associated with simple febrile seizures in Chinese Han population. Neurosci. Lett. 368, 2–6.10.1016/j.neulet.2004.06.054Suche in Google Scholar PubMed

Yinan, M.A., Yu, Q., Zhiyue, C., Liping, Z., Fang, F., Liwen, W., Fuying, S., Jianhui, Z., Dingfang, B., Tianjun, W., et al. (2006). HCN2, NRTN, CAPS and GPX4 genes are not associated with simple febrile seizures in Chinese Han population. J. Pediatr. Neurol. 4, 83–87.10.1055/s-0035-1557316Suche in Google Scholar

Yoon, J.W., Choen, E.J., and Lee, Y.H. (2008). Polymorphisms of interleukin-1β promoter in simple febrile seizures. Korean J. Pediatr. 51, 1007–1011.10.3345/kjp.2008.51.9.1007Suche in Google Scholar

Yoon, J., Choi, B., Park, Y., Kang, Y., Nam, S., Lee, J., and Park, W.S. (2012). Lack of association of SCN2A and KCNJ10 polymorphisms in Korean children with epilepsy: intractability and relapse of epilepsy. Mol. Cell. Toxicol. 8, 61–67.10.1007/s13273-012-0008-6Suche in Google Scholar

Yu-jie1a, L., Yin-nan1b, M., Zu-geng, C., Gu1a, T., Li-ping, Z., Fang, F., et al. (2008). Association study on simple febrile seizures and casein kinase 1, gamma 1 gene [J]. J. Appl. Clin. Pediatr. 4, 025.Suche in Google Scholar

Zhang, C., Wong, V., Ng, P.W., Lui, C.H.T., Sin, N.C., Wong, K.S., Baum, L., and Kwan, P. (2010). Failure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile seizures in Chinese patients with epilepsy. Epilepsia 51, 1878–1881.10.1111/j.1528-1167.2010.02587.xSuche in Google Scholar PubMed

Zhao, F., Liu, X.-m., Ke, X.-y., Ming, M., Gui, W.-x., Zhao, D.-c., Wang, D.-b. (2010). Association of febrile seizures and human myo-inositol monophosphatase 2 gene. J. Appl. Clin. Pediatr. 12, 017.Suche in Google Scholar

Received: 2013-11-16
Accepted: 2013-12-5
Published Online: 2014-01-08
Published in Print: 2014-02-01

©2014 by Walter de Gruyter Berlin Boston

Heruntergeladen am 7.11.2025 von https://www.degruyterbrill.com/document/doi/10.1515/revneuro-2013-0053/html
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