In vitro degradation of polyglycolic acid synthesized by a one-step reaction
-
Siye Tang
,
Guilian Li
Abstract
Polyglycolic acid was synthesized by a one-step reaction of chloroacetic acid and triethylamine in tetrahydrofuran. The hydrolytic degradation of polyglycolic acid has been investigated. The in vitro degradation was investigated in a saline phosphate buffer. The degradation process was examined using Fourier transform infrared spectroscopy spectrum, weight loss, melting point, X-ray powder diffraction, pH, and scanning electron microscopy measurements. The chemical structure of polyglycolic acid has a small change during in vitro degradation. Degradation occurred with an increase in weight loss, a decrease in melting point, an increase in crystallinity during the initial degradation period and then a decrease afterwards. The melting point fell abruptly after the sixth week. This indicates that the degradation degree increased suddenly, i.e., the molecular weight of polyglycolic acid should decrease abruptly. The pH of the buffer solution fell quickly and decreased with time during in vitro degradation. The lower pH indicates that the molecular weight of polyglycolic acid synthesized by a one-step reaction should be low, and this may enable polyglycolic acid to degrade easily. As the degradation time increased, the surfaces of polyglycolic acid samples were highly degraded, and the surface porosity increased.
Acknowledgments
This work was financially supported by the Department of Science and Technology of Henan Province (No. 112102310575).
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©2014 by De Gruyter
Artikel in diesem Heft
- Frontmatter
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- Editorial improvements at the Journal of Polymer Engineering
- Original articles
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Artikel in diesem Heft
- Frontmatter
- Editorial
- Editorial improvements at the Journal of Polymer Engineering
- Original articles
- Cationic copolymerization of 1,3-pentadiene with α-pinene
- In vitro degradation of polyglycolic acid synthesized by a one-step reaction
- Synthesis of a novel class of mixed-type surfmers and their properties in water
- Unique viscosity mutation of multi-generation hyperbranched waterborne polyurethane
- Preparation and characterization of oxidized starch-graft-poly(styrene-butyl acrylate) latex via emulsion polymerization
- Peroxide vulcanization of natural rubber. Part I: effect of temperature and peroxide concentration
- The stimuli-response characters of hydrogels prepared using ultrasound
- A new conductometric biosensor based on horseradish peroxidase immobilized on chitosan and chitosan/gold nanoparticle films
- A new approach for the development of textile waste cotton reinforced composites (T-FRP): laminated hybridization vs. coupling agents
- Effects of the surface treatment of wollastonite on the tensile and flow properties for reinforced polypropylene composites
- Effect of the quenching temperature on the mechanical and thermophysical properties of polycarbonate pigmented with titanium dioxide
- Processing and characterization of poly(lactic acid) blended with polycarbonate and chain extender
- Characteristics analysis and mold design for ultrasonic-assisted injection molding
