Effect of prenatal tobacco smoke exposure on fetal growth potential
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Anastasia A. Varvarigou
Abstract
Aim: To determine the independent effect of prenatal tobacco smoke exposure on fetal growth using customized birthweight norms.
Methods: Demographic characteristics and data on exposure to tobacco smoke during pregnancy were obtained from singleton neonates ≥34 weeks' gestation. Centile Calculator software v62.2 (www.gestation.net) was used for calculating customized birthweight percentiles.
Results: Of the 3227 neonates studied, 30.9% were exposed to maternal smoking during pregnancy, whereas involuntary maternal exposure was reported in 20.1%. Growth restriction was noted in 350 (10.8%). The odds ratio (OR) for fetal growth restriction was 1.49 (1.10–1.91) in passive smokers, and 2.34 (1.81–2.96) in smokers. A decrease in birthweight and an increase in the prevalence of growth restriction with the increasing number of cigarette consumption was observed. This effect was evident even in cases of a “minimal” consumption of 1–5 cigarettes per day.
Conclusion: An essential adverse effect of tobacco smoke exposure on fetal growth in pregnancies exposed to passive smoking, as well as in those with “minimal” maternal cigarette consumption, was found. Since approximately 30% of growth restricted neonates could be independently attributed to active or passive maternal exposure, these findings reinforce the need for smoking preventive strategies in pregnant women and their environment.
©2010 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Editorial
- Late motherhood and cesarean delivery
- Review article
- Oxygen and oxidative stress in bronchopulmonary dysplasia
- A statement of the World Association of Perinatal Medicine
- Ethical dimensions of periviability
- Opinion Paper
- The role of melatonin in post-partum psychosis and depression associated with bipolar disorder
- Original articles – Obstetrics
- Low maternal serum matrix metalloproteinase (MMP)-2 concentrations are associated with preterm labor and fetal inflammatory response
- Comparison of complications in second trimester amniocentesis performed with 20G, 21G and 22G needles
- Genome profiles in maternal blood during early onset preeclampsia and towards term
- Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy
- Evidence of the escape of antithrombin from the blood into the interstitial space in pregnant women
- Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term
- Does very advanced maternal age, with or without egg donation, really increase obstetric risk in a large tertiary center?
- A great lack of knowledge regarding umbilical cord blood banking among pregnant women in Berlin, Germany
- Long chain polyunsaturated fatty acids in mothers of preterm babies
- Original articles – Fetus
- The expression pattern of two novel cytokines (IL-24 and IL-29) in human fetal membranes
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- Original articles – Newborn
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- Neonatal abstinence syndrome (NAS) after intrauterine exposure to tramadol
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- Congress Calendar
- Congress Calendar
