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Oxygen and oxidative stress in bronchopulmonary dysplasia
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Ola Didrik Saugstad
Published/Copyright:
August 31, 2010
Abstract
Aims: To summarize present knowledge regarding the relation between oxidative stress and development of bronchopulmonary dysplasia (BPD).
Methods: Relevant literature searched at Pubmed and other sources.
Results: Oxidative stress is generated in a number of conditions and by a number of causes such as inflammation and hyperoxia. Ontogenic aspects are discussed. Oxidative stress as physiological regulators, its relation to transcription factors and inflammation is summarized. The role of oxygen and antioxidant therapy and newborn resuscitation for development and prevention of BPD as well as new therapeutic modes especially the use of growth factors, gene therapy and stem cells, are briefly discussed.
Conclusion: Oxidative stress and BPD are associated. A better understanding of this association is necessary in order to reduce the severity and the incidence of the condition.
Keywords: Bronchopulmonary dysplasia; oxidative stress
Received: 2010-6-14
Accepted: 2010-6-18
Published Online: 2010-08-31
Published Online: 2010-08-31
Published in Print: 2010-11-01
©2010 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Editorial
- Late motherhood and cesarean delivery
- Review article
- Oxygen and oxidative stress in bronchopulmonary dysplasia
- A statement of the World Association of Perinatal Medicine
- Ethical dimensions of periviability
- Opinion Paper
- The role of melatonin in post-partum psychosis and depression associated with bipolar disorder
- Original articles – Obstetrics
- Low maternal serum matrix metalloproteinase (MMP)-2 concentrations are associated with preterm labor and fetal inflammatory response
- Comparison of complications in second trimester amniocentesis performed with 20G, 21G and 22G needles
- Genome profiles in maternal blood during early onset preeclampsia and towards term
- Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy
- Evidence of the escape of antithrombin from the blood into the interstitial space in pregnant women
- Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term
- Does very advanced maternal age, with or without egg donation, really increase obstetric risk in a large tertiary center?
- A great lack of knowledge regarding umbilical cord blood banking among pregnant women in Berlin, Germany
- Long chain polyunsaturated fatty acids in mothers of preterm babies
- Original articles – Fetus
- The expression pattern of two novel cytokines (IL-24 and IL-29) in human fetal membranes
- The source of error in the estimation of intertwin birth weight discordance
- Original articles – Newborn
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